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  1. Research article

    Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department

    The blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI). This ratio is sim...

    Guillaume Manoeuvrier, Kalyane Bach-Ngohou, Eric Batard, Damien Masson and David Trewick

    BMC Nephrology 2017 18:173

    Published on: 25 May 2017

  2. Research article

    Urinary neprilysin in the critically ill patient

    Critically ill patients in intensive care face hazardous conditions. Among these, acute kidney injury (AKI) is frequently seen as a result of sepsis. Early diagnosis of kidney injury is of the utmost importanc...

    Sahra Pajenda, Karl Mechtler and Ludwig Wagner

    BMC Nephrology 2017 18:172

    Published on: 25 May 2017

  3. Research article

    The effect of disease severity markers on quality of life in autosomal dominant polycystic kidney disease: a systematic review, meta-analysis and meta-regression

    Little is known about determinants of quality of life (QoL) in autosomal dominant polycystic kidney disease (ADPKD). Recent studies suggest that QoL in ADPKD is determined by more factors than mere renal funct...

    Myrte K. Neijenhuis, Wietske Kievit, Ronald D. Perrone, Jeff A. Sloan, Patricia Erwin, Mohammad Hassan Murad, Tom J. G. Gevers, Marie C. Hogan and Joost P. H. Drenth

    BMC Nephrology 2017 18:169

    Published on: 25 May 2017

  4. Research article

    Periodontitis and early mortality among adults treated with hemodialysis: a multinational propensity-matched cohort study

    Periodontitis is associated with cardiovascular mortality in the general population and adults with chronic diseases. However, it is unclear whether periodontitis predicts survival in the setting of kidney fai...

    Marinella Ruospo, Suetonia C Palmer, Germaine Wong, Jonathan C Craig, Massimo Petruzzi, Michele De Benedittis, Pauline Ford, David W Johnson, Marcello Tonelli, Patrizia Natale, Valeria Saglimbene, Fabio Pellegrini, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Torok…

    BMC Nephrology 2017 18:166

    Published on: 22 May 2017

  5. Research article

    Clinical outcomes of linezolid and vancomycin in patients with nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus stratified by baseline renal function: a retrospective, cohort analysis

    The primary objective of this study is to assess whether baseline renal function impacts treatment outcomes of linezolid and vancomycin (with a dose-optimized regimen) for methicillin-resistant Staphylococcus aur...

    Ping Liu, Blair Capitano, Amy Stein and Ali A. El-Solh

    BMC Nephrology 2017 18:168

    Published on: 22 May 2017

  6. Research article

    Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients – a prospective study

    Circulating pro-inflammatory cytokines were associated with increased relative mortality risk, while immune parameters reflecting improved T-cell function were predictors of survival in hemodialysis (HD) patie...

    Alicja E. Grzegorzewska, Monika K. Świderska, Adrianna Mostowska, Wojciech Warchoł and Paweł P. Jagodziński

    BMC Nephrology 2017 18:165

    Published on: 19 May 2017

  7. Research article

    Increased resistance of gram-negative urinary pathogens after kidney transplantation

    Urinary tract infection is the most common complication after kidney transplantation. It can cause severe sepsis and transplant loss. Emergence of drug resistance among gram-negative urinary pathogens is the c...

    Johannes Korth, Julia Kukalla, Peter-Michael Rath, Sebastian Dolff, Marco Krull, Hana Guberina, Anja Bienholz, Benjamin Wilde, Stefan Becker, Birgit Ross, Olympia Evdoxia Anastasiou, Andreas Kribben and Oliver Witzke

    BMC Nephrology 2017 18:164

    Published on: 19 May 2017

  8. Research article

    Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study

    Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate. We examined whether metformin use was associated with an increased risk of acute kidney injury...

    Samira Bell, Bassam Farran, Stuart McGurnaghan, Rory J. McCrimmon, Graham P Leese, John R Petrie, Paul McKeigue, Naveed Sattar, Sarah Wild, John McKnight, Robert Lindsay, Helen M. Colhoun and Helen Looker

    BMC Nephrology 2017 18:163

    Published on: 19 May 2017

  9. Research article

    Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study

    The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask f...

    Akinori Yamaguchi, Makoto Harada, Yosuke Yamada, Koji Hashimoto and Yuji Kamijo

    BMC Nephrology 2017 18:162

    Published on: 18 May 2017

  10. Research article

    Vitamin D receptor activation reduces inflammatory cytokines and plasma MicroRNAs in moderate chronic kidney disease – a randomized trial

    Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD), partly due to endothelial dysfunction and chronic inflammation. Vitamin D treatment in end stage renal disease is suggested to...

    Ladan Mansouri, Kristina Lundwall, Ali Moshfegh, Stefan H. Jacobson, Joachim Lundahl and Jonas Spaak

    BMC Nephrology 2017 18:161

    Published on: 16 May 2017

  11. Research article

    The association between urbanization and reduced renal function: findings from the China Health and Nutrition Survey

    While chronic kidney disease (CKD) is a growing public health concern in low- and middle-income countries, such as China, few studies have investigated the association between urbanization and the occurrence o...

    Yosuke Inoue, Annie Green Howard, Amanda L. Thompson, Michelle A. Mendez, Amy H. Herring and Penny Gordon-Larsen

    BMC Nephrology 2017 18:160

    Published on: 15 May 2017

  12. Research article

    Prevalence and correlates of cognitive impairment in kidney transplant recipients

    There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown.

    Aditi Gupta, Jonathan D. Mahnken, David K. Johnson, Tashra S. Thomas, Dipti Subramaniam, Tyler Polshak, Imran Gani, G. John Chen, Jeffrey M. Burns and Mark J. Sarnak

    BMC Nephrology 2017 18:158

    Published on: 12 May 2017

  13. Case report

    Clinical improvement of renal amyloidosis in a patient with systemic-onset juvenile idiopathic arthritis who received tocilizumab treatment: a case report and literature review

    Juvenile idiopathic arthritis (JIA) is a common rheumatic disease in children and adolescents. Although JIA may cause secondary amyloidosis, this is a rare complication in patients with JIA and other rheumatic...

    Songkiat Chantarogh, Soamarat Vilaiyuk, Thipwimol Tim-Aroon and Suchin Worawichawong

    BMC Nephrology 2017 18:159

    Published on: 12 May 2017

  14. Case report

    Ultrastructural deposits appearing as “zebra bodies” in renal biopsy: Fabry disease?– comparative case reports

    Fabry Disease (FD) is a genetic disorder caused by alpha-galactosidase A deficiency. Certain drugs, such as hydroxychloroquine, can produce renal deposits that mimic morphological findings seen in FD, characte...

    Precil Diego Miranda de Menezes Neves, Juliana Reis Machado, Fabiano Bichuette Custódio, Maria Luíza Gonçalves dos Reis Monteiro, Shigueo Iwamoto, Marlene Freire, Marisa França Ferreira and Marlene Antônia dos Reis

    BMC Nephrology 2017 18:157

    Published on: 12 May 2017

  15. Research article

    Patterns of use and appropriateness of antibiotics prescribed to patients receiving haemodialysis: an observational study

    There are limited published data on the types and appropriateness of oral and intravenous (IV) antibiotics prescribed to patients receiving haemodialysis. This information is critical to optimise antibiotic pr...

    Katrina Hui, Michelle Nalder, Kirsty Buising, Aspasia Pefanis, Khai Y Ooi, Eugenie Pedagogos, Craig Nelson, Carl M. J. Kirkpatrick and David C. M. Kong

    BMC Nephrology 2017 18:156

    Published on: 12 May 2017

  16. Study protocol

    Exploring the utility and scalability of a telehomecare intervention for patients with chronic kidney disease undergoing peritoneal dialysis—a study protocol

    Chronic Kidney Disease (CKD) is a pressing global health concern that is placing increased strain on health care resources. CKD patients regularly receive peritoneal dialysis as a common CKD treatment. An emer...

    Lianne Jeffs, Arsh Kumar Jain, Rachel HiuTung Man, Nike Onabajo, Laura Desveaux, James Shaw, Jennifer Hensel, Payal Agarwal, Marianne Saragosa, Trevor Jamieson, Ivy Wong, Maria Maione and R. Sacha Bhatia

    BMC Nephrology 2017 18:155

    Published on: 10 May 2017

  17. Research article

    Changes in physical activity and risk of all-cause mortality in patients on maintence hemodialysis: a retrospective cohort study

    A previous cohort study indicated a significant association of lower baseline level of physical activity in hemodialysis patients with elevated risks of mortality. However, there have been no reports regarding...

    Takahiro Shimoda, Ryota Matsuzawa, Kei Yoneki, Manae Harada, Takaaki Watanabe, Mika Matsumoto, Atsushi Yoshida, Yasuo Takeuchi and Atsuhiko Matsunaga

    BMC Nephrology 2017 18:154

    Published on: 8 May 2017

  18. Research article

    Renal replacement therapy in acute kidney injury from a Chinese cross-sectional study: patient, clinical, socioeconomic and health service predictors of treatment

    Renal replacement therapy (RRT) is important to support critically ill patients with acute kidney injury (AKI). This study, a part of a nation-wide survey for AKI conducted by the ISN AKF 0 by 25 China Consort...

    Fang Wang, Daqing Hong, Yafang Wang, Yunlin Feng, Li Wang and Li Yang

    BMC Nephrology 2017 18:152

    Published on: 4 May 2017

  19. Research article

    The impact of continuous renal replacement therapy on renal outcomes in dialysis-requiring acute kidney injury may be related to the baseline kidney function

    Many controversies exist regarding the management of dialysis-requiring acute kidney injury (D-AKI). No clear evidence has shown that the choice of dialysis modality can change the survival rate or kidney func...

    Marisa Aparecida de Souza Oliveira, Thais Oliveira Claizoni dos Santos, Julio Cesar Martins Monte, Marcelo Costa Batista, Virgilio Gonçalves Pereira, Bento Fortunato Cardoso dos Santos, Oscar Fernando Pavão Santos and Marcelino de Souza Durão

    BMC Nephrology 2017 18:150

    Published on: 3 May 2017

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