Sub-study | Specific aim |
---|---|
1. Antihypertensive management | a. To assess the comparative effectiveness of ACE inhibitors/ARBs , Beta Blockers, and Calcium Channel Blockers in preventing all cause and cardiovascular disease (CVD) mortality among dialysis patients |
 | b. To assess the comparative effectiveness of ACE inhibitors/ARBs, Beta Blockers and Calcium Channel Blockers in preventing morbidity (CVD events, all cause hospitalizations, quality of life, worsening disability) among patients on dialysis |
2. Timing of dialysis initiation | a. To assess the comparative effectiveness of early versus conventional dialysis initiation on risk of all cause and cardiovascular mortality |
 | b. To assess the comparative effectiveness of early versus conventional dialysis initiation on morbidity (cardiovascular events, all cause and infectious hospitalizations, health-related quality of life, comorbid disease control, and nutritional status) |
3. Intravenous iron for anemia management | a. To compare the effectiveness of iron dosing strategies (regular maintenance therapy versus intermittent ‘as needed’ therapy) on anemia management |
 | b. To assess the comparative effectiveness of lower versus higher cumulative IV iron doses on CVD-related hospitalization and mortality, infection-related hospitalization and mortality, all cause mortality, and quality of life |