Table 3 IL12 and IL18 polymorphisms in hemodialysis patients with a titre of antibodies to surface antigen of hepatitis B virus ≤ 10 UI/L (Group II) and controls
Variable | Group I (n = 207) n (%) | Controls (n = 240) N (%) | OR (95 % CI) | P value | Genotype frequencies (n, %) expected by Hardy-Weinberg equilibrium Controls |
|---|---|---|---|---|---|
IL12A rs568408 | |||||
GG | 157 (75.8) | 171 (71.3) | 1.00 | 171 (71.3) | |
GA | 41 (19.8) | 63 (26.3) | 0.71 (0.45 – 1.11) | 0.131 | 63 (26.3) |
AA | 9 (4.4) | 6 (2.5) | 1.63 (0.57 – 4.71) | 0.357 | 6 (2.5) |
GA/AA | 50 (24.2) | 69 (28.8) | 0.79 (0.52 – 1.21) | 0.272 | P = 1.000 |
IL12B rs3212227 | |||||
AA | 129 (62.3) | 151 (62.9) | 1.00 | 150 (62.3) | |
AC | 70 (33.8) | 77 (32.1) | 1.06 (0.71 – 1.59) | 0.761 | 80 (33.2) |
CC | 8 (3.9) | 12 (5.0) | 0.78 (0.31 – 1.97) | 0.597 | 11 (4.4) |
AC/CC | 78 (37.7) | 89 (37.1) | 1.03 (0.70 – 1.51) | 0.896 | P = 0.950 |
IL18 rs360719 | |||||
TT | 118 (57.0) | 121 (50.4) | 1.00 | 120 (50.2) | |
TC | 83 (40.1) | 98 (40.8) | 0.87 (0.59 – 1.28) | 0.475 | 99 (41.3) |
CC | 6 (2.9) | 21 (8.8) | 0.29 (0.11 – 0.75) | 0.006 | 20 (8.5) |
TC/CC | 89 (43.0) | 119 (49.6) | 0.77 (0.53 – 1.11) | 0.163 | P = 0.950 |