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Table 2 Patient baseline and demographic characteristics

From: An open-label, sequential, dose-finding study of peginesatide for the maintenance treatment of anemia in chronic hemodialysis patients

Characteristic

Cohort A n = 15

Cohort B n = 15

Cohort C n = 14

Cohort D n = 30

Cohort E n = 15

Cohort F n = 15

Cohort G n = 30

Cohort H n = 30

Total (N = 164)

Age, mean (SD), y

62.8 (18.8)

59.7 (14.2)

55.9 (14.8)

59.1 (14.3)

65.7 (11.8)

54.4 (18.3)

57.1 (16.0)

59.3 (13.8)

59.1 (15.2)

Men, no. (%)

6 (40.0)

9 (60.0)

10 (71.4)

17 (56.7)

8 (53.3)

10 (66.7)

13 (43.3)

21 (70.0)

94 (57.3)

Black, no. (%)

5 (33.3)

10 (66.7)

7 (50.0)

15 (50.0)

9 (60.0)

10 (66.7)

18 (60.0)

18 (60.0)

92 (56.1)

Hb, mean (SD), g/dL

11.6 (0.6)

11.6 (0.4)

11.7 (0.6)

11.5 (0.7)

11.4 (0.6)

11.5 (0.5)

11.5 (0.6)

11.5 (0.7)

11.5 (0.6)

Kt/V, mean (SD)

1.87 (0.83)

1.61 (0.18)

1.52 (0.22)

1.59 (0.27)

1.69 (0.24)

1.61 (0.29)

1.79 (0.33)

1.69 (0.24)

1.68 (0.36)

Ferritin, mean (SD), ng/mL

724.1 (212.2)

633.2 (321.2)

635.6 (423.2)

789.2 (510.0)

887.7 (413.4)

1073.9 (643.4)

665.6 (456.6)

564.0 (401.4)

727.1 (458.9)

TSAT, mean (SD),%

36.4 (9.5)

32.5 (4.9)

43.1 (12.0)

50.4 (19.4)

52.8 (17.1)

57.6 (16.3)

31.6 (10.3)

33.3 (12.0)

41.2 (16.5)

CHr, mean (SD), pg

31.7 (1.9)

32.1 (2.6)

32.2 (2.8)

32.4 (2.0)

33.2 (1.7)

32.3 (2.4)

32.3 (1.9)

32.7 (2.3)

32.4 (2.2)

Epoetin alfa dose, median

143

130

161

124

109

118

132

160

137

 (range)

(92–377)

(70–288)

(67–365)

(63–277)

(59–214)

(72–231)

(65–327)

(80–367)

(59–377)

 U/kg/wk

9997

12444

12598

9603

9547

7600

7398

7598

8567

 U/wk

(6371–33650)

(4634–21709)

(6593–36590)

(3602–24597)

(4544–30445)

(5066–10140)

(4797–10666)

(965–14820)

(965–36590)

Primary cause of CKD, no. (%)

         

 Diabetes

6 (40.0)

6 (40.0)

6 (42.9)

12 (40.0)

6 (40.0)

3 (20.0)

11 (36.7)

17 (56.7)

67 (40.9)

 Hypertension

4 (26.7)

4 (26.7)

2 (14.3)

13 (43.3)

6 (40.0)

9 (60.0)

15 (50.0)

8 (26.7)

61 (37.2)

 Other

5 (33.3)

5 (33.3)

6 (42.9)

5 (16.7)

3 (20.0)

3 (20.0)

4 (13.3)

5 (16.7)

36 (22.0)

  1. Abbreviations: SD, standard deviation; Hb, hemoglobin; Kt/V, urea clearance per volume; TSAT, transferrin saturation; CHr, reticulocyte hemoglobin content; CKD, chronic kidney disease.
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