Rifampin-associated tubulointersititial nephritis and Fanconi syndrome presenting as hypokalemic paralysis

BMC Nephrology

Table 1 Biochemical Data on Admission and after Rifampin Withdrawal

	Admission	2 weeks	3 months	6 months	8 months
Serum
Urea nitrogen (mg/dL)	13.9	-	18.5	15.9	15.9
Creatinine (mg/dL)	1.4	-	1.12	1.18	1.09
Potassium (mmol/L)	2.0	3.8	3.8	3.7	4.3
pH	7.289	7.260	7.387	7.381	7.367
Bicarbonate (mmol/L)	12.4	14.5	22.8	23.3	24.4
Phosphate (mg/dL)	1.2	2.7	5.2	4.4	4.6
Uric acid (mg/dL)	1.2	1.3	3.9	4.5	4.2
Sodium (mmol/L)	141	140	140	140	142
Chloride (mmol/L)	114	112	103	103	106
Magnesium (mg/dL)	2.1	2.3	2.5	2.3	2.3
Albumin (g/dL)	4.7	-	-	4.3	4.3
Urine
24-h glucose (g/day)	16.90	-	0.05	0.06	-
β₂-microglobulin (μg/L)^*	>20000	-	1238	265	-
Potassium (mEq/L)	7.2		29.5	61.4	67
Phosphate (mg/dL)	11.7		33.7	69.5	96.8
Uric acid (mg/dL)	11.4		28.1	-	67.3
Creatinine (mg/dL)	17.2		38.99	189.7	171
FE_K (%)^†	29.33	-	22.29	10.32	9.80
TmP/GFR (mg/dL)^‡	0.24	-	4.23	3.96	3.98
FE_UA (%)^§	77.41	-	20.69	-	10.2
pH	5.5	6.0	5.0	5.0	5.5
24-h protein (g/day)	2.50	0.91	0.10	0.14	0.01

Note: Replacement of potassium chloride and sodium bicarbonate was interrupted at 3 months after admission.
^*Normal, less than 370 mg/L.
^† Normal, 4-16%.
^‡Normal, 2.3 to 4.3.
^§Normal, 6-20%.
FE_K, fractional excretion of potassium; TmP/GFR, tubular maximal transport of phosphate reabsorption to the glomerular filtration rate transport; FE_UA, fractional excretion of uric acid.

ISSN: 1471-2369