Table 5 Blood parameter, treatment dose and variability (MSSD) of Period 1–2 vs. Period 3–4, Darbepoetin alfa
Darbepoetin alfa | Period 1–2 | Period 3–4 | p-value |
|---|---|---|---|
(n = 19) | (n = 19) | ||
Hemoglobin, g/dl (mean, SD) | 11.0 (0.9) | 11.4 (0.7) | 0.15 |
Reticulocyte count, cells/μl (mean, SD) | 67543 (19668) | 72766 (18220) | 0.41 |
Ferritin, μg/l (mean, SD) | 465.9 (156.1) | 478.9 (98.3) | 0.76 |
Cumulated ESA dose, μg (mean, SD) | 1121.6 (744.6) | 865.6 (622.9) | 0.26 |
Cumulated iron dose, μg (mean, SD) | 705.6 (340.4) | 611.1 (286.7) | 0.37 |
ST-MSSD Hb, g 2 /dl 2 (mean, SD) | 0.54 (0.35) | 0.67 (0.45) | 0.30 |
LT-MSSD Hb, g 2 /dl 2 (mean, SD) | 0.28 (0.24) | 1.01 (1.24) | 0.02 |
ST-MSSD Ret, cells 2 /μl 2 (mean, SD) | 48.4x108 (40.3x108) | 20.3x108 (20.5x108) | 0.01 |
LT-MSSD Ret, cells 2 /μl 2 (mean, SD) | 2.0x108 (2.4x108) | 6.9x108 (9.7 x108) | 0.04 |
LT-MSSD ESA, μg 2 (mean, SD) | 1701 (2113) | 15650 (41055) | 0.07 |