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Table 2 Results of Cox’s proportional hazards analysis of clinical parameters and all-cause mortality

From: Prognostic utility of plasma S100A12 levels to establish a novel scoring system for predicting mortality in maintenance hemodialysis patients: a two-year prospective observational study in Japan

 

Univariate analysis

Multivariate analysis in a stepwise procedure

Beta coefficient

unadjusted HR

95%CI

P value

Beta coefficient

adjusted HR

95%CI

P value

Age ≥65 years

0.972

2.643

1.425–4.900

0.002**

0.674

1.961

1.017–3.781

0.044*

Male

−0.003

0.997

0.560–1.776

0.992

    

Current smoker

0.190

1.210

0.544–2.689

0.648

    

Duration of HD ≥10 years

−0.068

0.934

0.520–1.677

0.819

    

Systolic BP <110 mmHg

0.721

2.057

0.759–5.575

0.156

    

110–140 mmHg

-

-

-

-

    

≥140 mmHg

0.158

1.171

0.641–2.140

1.171

    

Hemoglobin <10 g/dL

0.006

1.006

0.554–1.826

0.984

    

10–11 g/dL

-

-

-

-

    

≥11 g/dL

0.569

1.767

0.681–4.589

0.242

    

White blood cells ≥10000/mm3

−0.112

0.894

0.123–6.472

0.911

    

Platelet ≥35 × 104/μL

0.330

0.719

0.175–2.959

0.648

    

hs-CRP ≥3 mg/L

0.957

2.604

1.490–4.552

0.001**

    

Albumin <3.5 g/dL

1.016

2.761

1.580–4.828

<0.001**

0.788

2.198

1.218–3.968

0.012*

Potassium ≥5.5 mEq/L

0.128

1.136

0.484–2.667

0.769

    

Phosphate ≥6 mg/dL

−0.211

0.810

0.322–2.041

0.655

    

Total Cholesterol ≥200 mg/dL

0.123

1.130

0.508–2.513

0.764

    

DN

0.300

1.349

0.772–2.359

0.293

    

History of CVD

1.045

2.844

1.615–5.009

<0.001**

0.727

2.068

1.146–3.732

0.016*

Plasma S100A12 levels ≥18.79 ng/mL

0.967

2.631

1.419–4.878

0.002**

0.919

2.267

1.195–4.302

0.012*

  1. HD = hemodialysis, BP = blood pressure, hs-CRP = high-sensitivity C-reactive protein, DN = diabetic nephropathy, CVD = cardiovascular disease,
  2. HR = hazard ratio, 95%CI = 95% confidence interval.
  3. **P < 0.01, *P < 0.05.