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Table 4 Longitudinal associations between anthropometric/ blood parameters and ACR 1 by sex

From: Body mass index and metabolic factors predict glomerular filtration rate and albuminuria over 20 years in a high-risk population

 

Previous parameters (over 20 years ago)

Previous parameters (10 to 20 years ago)

Previous parameters (5 to 10 years ago)

Current parameters (RENVOR)

 

Beta (95% CI)

 

Women

N

34

34

34

34

Follow-up [years], median (Q1, Q3)

24.7 (24.0, 25.2)

14.9 (14.1, 15.3)

7.5 (7.1, 7.9)

-

BMI [kg/m2]

0.03 (−0.03, 0.09)

0.02 (−0.02, 0.06)

0.00 (−0.03, 0.04)

0.00 (−0.04, 0.04)

Systolic blood pressure [mmHg]

−0.00 (−0.02, 0.01)

0.00 (−0.01, 0.01)

−0.00 (−0.01, 0.01)

-

Log(Glucose) [mmol/l]

* 0.91 (0.09, 1.73)

0.13 (−1.18, 1.44)

0.53 (−0.71, 1.77)

-

Total cholesterol [mmol/l]

−0.09 (−0.46, 0.27)

−0.05 (−0.35, 0.24)

* -0.39 (−0.67, −0.11)

* -0.28 (−0.54, −0.02)

Log(Triglicerides) [mmol/l]

−0.27 (−1.27, 0.74)

0.06 (−0.42, 0.54)

−0.17 (−0.72, 0.38)

0.20 (−0.35, 0.75)

Log(Gamma-GT) [units/l]

0.28 (−0.26, 0.82)

0.07 (−0.37, 0.51)

0.01 (−0.33, 0.35)

0.02 (−0.25, 0.29)

 

Men

N

42

42

42

42

Follow-up [years], median (Q1, Q3)

24.3 ( 22.8, 25.3)

14.9 (14.1, 15.9)

7.4 (6.9, 8.1)

-

BMI [kg/m2]

* 0.14 (0.03, 0.25)

0.08 (−0.02, 0.18)

0.09 (−0.00, 0.19)

0.06 (−0.04, 0.16)

Systolic blood pressure [mmHg]

−0.01 (−0.03, 0.01)

0.01 (−0.01, 0.04)

* 0.03 (0.01, 0.05)

-

Log(Glucose) [mmol/l]

0.23 (−0.83, 1.29)

* 2.27 (1.38, 3.16)

* 2.19 (0.71, 3.68)

-

Total cholesterol [mmol/l]

0.05 (−0.28, 0.38)

−0.01 (−0.38, 0.37)

−0.33 (−0.72, 0.06)

−0.03 (−0.43, 0.36)

Log(Triglicerides) [mmol/l]

* 0.98 (0.26, 1.70)

* 0.95 (0.34, 1.55)

* 0.91 (0.22, 1.59)

0.67 (−0.23, 1.57)

Log(Gamma-GT) [units/l]

* 0.79 (0.24, 1.34)

* 0.72 (0.03, 1.41)

* 0.65 (0.07, 1.22)

0.43 (−0.13, 1.00)

  1. Models are adjusted for age.
  2. * Significant on alpha <0.05.
  3. 1 ACR log-transformed; one percent change (in the independent variable) would yield a percentage change in ACR in models where the independent variable is log-transformed.