Figure 1
eGWAS for kidney IRI using a χ 2 analysis. Plot of (-log10P value) (y axis) by chromosomal location (x axis). P values for each gene were calculated for 21 microarray experiments with 65 sham-operated or pre-transplant control microarray samples and 85 IRI or post-transplant microarray samples as the likelihood of finding repeated differential expression compared with expected using χ 2 analysis. Out of tested 17,575 genes 75 genes demonstrated a significant differential expression. The dotted line indicates the Bonferroni threshold (P = 2.84 × 10-6). The genes symbols indicate genes that are most significantly associated with kidney IRI, where underscored symbols indicate new candidate genes.