Figure 2
Analytical arrangement of available genomics studies of IRI in kidney and resulting lists of major IRI-associated candidate genes. Seventeen global transcriptional profiles were grouped into five clusters according to post-ischemia time. The species composition of each cluster is represented by a corresponding mammal. Vertical bars represent extend of significant expression of a particular gene throughout the five time-points. 46 upregulated and 1 downregulated candidate genes were selected by cross-referencing gene lists generated with χ2 test and W-scoring procedures (Venn diagram on the left). First tier candidate genes are depicted on the left and were significantly affected by IRI in at least four consecutive time-points. Each bar is filled with the corresponding gene symbol; where the open part of a bar is populated with the well known kidney IRI genes and grey area of the bar cover novel and new kidney IRI genes. The second tier candidate genes are listed on the right with the same color coding. The full names of depicted genes can be found in Table 1 (first tier) and Additional file 3. * The 4 genes from the third tier candidates (JUNB, ↓UPB1, CXCL10, CEBPD) are not included into the figure.