The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis

Table 5 Clinical variables associated with hepcidin-20 levels at at Spearman’s rho test (univariate analysis) and multivariate generalized linear model (GLM) in 99 CHD patients from Northern Italy (reported for p < 0.1 for clinical variable)

	Univariate		GLM
	R	P	Estimate	p
Hepcidin-25 nM	+0.60	<0.0001	+0.63	<0.0001
Active smoke	−0.25	<0.0001	−0.27	0.0016
Transferrin mg/dl	−0.23	0.032	-	-
TS%	+0.21	0.039	+0.13	0.22
TMPRSS6 A/A HFE muts + vs. other genotypes	−0.18	0.12	+0.13	0.99

TS: transferrin saturation; HFE muts +: positive for HFE mutations; GLM: generalized linear model.

ISSN: 1471-2369