Chronic kidney diseases in mixed ancestry south African populations: prevalence, determinants and concordance between kidney function estimators

Table 4 Multivariable adjusted odd ratios (and 95% confidence intervals) for the determinants of CKD stage 3-5

Variables	MDRD	MDRD corrected	CKD-EPI	CKD-EPI corrected	Cockroft-Gault
Age (/year)	1.09 (1.08-1.11)	1.11 (1.09-1.14)	1.14 (1.11-1.15)	1.14 (1.11-1.17)	1.21 (1.18-1.25)
Female gender	2.88 (1.92-4.38)	2.15 (1.18-4.14)	2.15 (1.36-3.47)	1.97 (1.07-3.83)	1.43 (0.84-2.45)
Cohort	0.27 (0.16-0.44)	0.50 (0.21-1.04)	0.39 (0.22-0.68)	0.31 (0.10-0.73)	0.30 (0.14-0.60)
Known hypertension	1.96 (1.35-2.90)	2.42 (1.28-4.94)	1.97 (1.25-3.15)	2.34 (1.20-4.93)	2.76 (1.56-5.00)
Triglycerides (/mmol/L)	NS	1.33 (1.04-1.67)	NS	1.33 (1.00-1.71)	NS
Body mass index (/kg/m²)	NS	NS	NS	NS	0.81 (0.77-0.85)
Total cholesterol (/mmol/L)	NS	NS	1.19 (1.02-1.39)	NS	NS

CKD-EPI, Chronic Kidney Disease Collaboration Epidemiology; 4-v-MDRD, four variable Modification of Diet in Renal Disease.
For CKD-EPI, TC was only significant when triglycerides (NS) was removed from the model, however triglycerides in the presence of other covariates except total cholesterol was not significant. For Cockroft-Gault: Hip was significant when replacing waist circumference in the models, not in its presence. And hypertension was significant only in the presence of body mass index in the model.

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