Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy

BMC Nephrology

Table 4 Multivariate analysis for predictors of 10% tubular atrophy/interstitial fibrosis in IgA nephropathy

	Predictors	OR	95%C.I.	P
The whole cohort (N = 623)
	eGFR	0.968	0.961-0.975	<0.001
	HUA	1.585	1.091-2.303	0.016
Subgroup with eGFR > =90 ml/min/1.73 m ² (N = 258)
	HUA	2.097	1.112-3.957	0.022
Subgroup with eGFR < 90 ml/min/1.73 m ² (N = 365)
	eGFR	0.9578	0.944-0.969	<0.001

Analyses were performed with logistic regressions in the whole cohort and the subgroup. Tubular atrophy/ interstitial fibrosis were analyzed as two groups, less than 10% interstitial fibrosis/tubular atrophy or more than 10% lesion (Tadj_Bj0 < 10%, Tadj_Bj1 >= 10%). In each Model, physical and biochemical traits including age, gender, BMI, baseline-eGFR, baseline UP, SBP, DBP, drug therapy and hyperuricemia status were analyzed by single factor analysis first, and factors that were significant were then put into multiple factor model. Result by multiple factor analysis was presented. HUA: hyperuricemia (male >420 μmol/L, female >360 μmol/L); eGFR: estimated GFR.

ISSN: 1471-2369