Table 6 Changes in calcium supplements, alfacalcidol, paricalcitol, calcimimitecs, phosphate binders and erythropoietin analogues in a randomized, placebo-controlled study investigating the effects of cholecalciferol supplementation for 6 months in 50 patients on dialysis
Vitamin D analogues | Calcimimetic | Phospahte binders | Erythropoietin analogues | ||||||
|---|---|---|---|---|---|---|---|---|---|
Alfacalcidol | Paricalcitol | Cinecalcet | UnikalkA | Sevelamer | Lanthanum | OsvarenB | Epoetin | Darbapeotin | |
Placebo (changes from baseline) | |||||||||
Increased dose (n) | 7 | 0 | 1 | 0 | 6 | 1 | 7 | 1 | 7 |
Same dose (n) | 10 | 25 | 23 | 22 | 13 | 23 | 12 | 23 | 6 |
Reduced dose (n) | 8 | 0 | 1 | 3 | 6 | 1 | 6 | 1 | 12 |
Mean change in dose | 0.2 ± 4.3 μg/week | 0 ± 0 μg/week | 0.0 ± 26 mg/day | -0.4 ± 1.0 tablets/day | 0.0 ± 2.4 g/day | 30 ± 340 mg/day | -0.1 ± 2.8 tablets/day | 160 ± 2939 IU/week | -4.8 ± 22.6 μg/week |
Cholecalciferol (changes from baseline) | |||||||||
Increased dose (n) | 8 | 1 | 1 | 2 | 3 | 3 | 3 | 0 | 9 |
Same dose (n) | 12 | 23 | 22 | 17 | 14 | 18 | 17 | 25 | 6 |
Reduced dose (n) | 5 | 1 | 2 | 6 | 8 | 4 | 5 | 0 | 10 |
Mean change in dose | 0.7 ± 3.0 μg/week | 0 ± 4 μg/week | -2.4 ± 21 mg/day | -0.6 ± 1.4 tablets/day | -0.6 ± 1.8 g/day | 30 ± 931 mg/day | -0.4 ± 2.0 tablets/day | 0 ± 0 IU/week | 3.2 ± 34.0 μg/week |