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Table 4 Changes in echocardiographic parameters from baseline to 12 months in both groups

From: Regression of cardiac growth in kidney transplant recipients using anti-m-TOR drugs plus RAS blockers: a controlled longitudinal study

 

Δ, m-TOR group ( P)

Δ, Control group ( P)

Δ Effect (m-TOR vs Control) (95%CI)

P value

LAD (mm)

0.90 ± 15

0.30 ± 14

0.59 ± 3.4

0.859

(0.4)

(0.6)

(-6 to 7.3)

LVEDD (mm)

45.8 ± 10

44 ± 9

1.8 ± 2.1

0.428

(0.7)

(0.2)

(-2.5 to 5.8)

IVS (mm)

5.3 ± 8.5

3.1 ± 16

2.2 ± 2.7

0.427

(0.002)

(0.04)

(-3.1 to 7.4)

PWT (mm)

7 ± 10

4.9 ± 14

2.1 ± 2.7

0.415

(0.001)

(0.01)

(-3.1 to 7.5)

RWT

4.8 ± 14

5 ± 17

0.2 ± 3.7

0.949

(0.026)

(0.035)

(-7.1 to 7.6)

EF (%)

6.6 ± 11

0.5 ± 16

6.1 ± 3.6

0.101

(0.7)

(0.2)

(-1.2 to 13)

FS (%)

-1.05 ± 21

-8 ± 25

7.1 ± 5.4

0.197

(0.2)

(0.02)

(-3.7 to 18)

LVMi (g/m 2.7 )

8.4 ± 18

3.8 ± 16

4.5 ± 3.9

0.255

(0.003)

(0.052)

(-3.4 to 12)

Peak E (cm/sec)

-19.4 ± 43

-6.4 ± 25.6

-13 ± 9

0.135

(0.034)

(0.4)

(-30 to 4.6)

Peak A (cm/sec)

-11.1 ± 33

-9.3 ± 27

-1.7 ± 7

0.808

(0.3)

(0.1)

(-16 to 12)

E/A ratio

-0.06 ± 0.34

-0.001 ± 0.34

-12.6 ± 9.8

0.429

(0.3)

(0.9)

(-32 to 7)

DT (msec)

-18.2 ± 9

-5 ± 40

-13 ± 7.8

0.019

(0.05)

(0.8)

(-29 to 3.5)

LVIRT (msec)

-10.3 ± 33

-3 ± 31

-7.1 ± 7.5

0.341

(0.4)

(0.5)

(-22 to 8)

  1. Δ, percent increase or decrease from baseline ([baseline value – final value] x 100/baseline value). Values are expressed as mean ± SD; values in parentheses are P values for the differences between final and baseline absolute values, and 95% confidence intervals for the control versus m-TOR group effect.
  2. Abbreviations: LAD, left atrial diameter; LVEDD, left ventricular end-diastolic diameter; IVS, interventricular septal thickness; PWT, posterior wall thickness; RWT, relative wall thickness; FS, left ventricular fractional shortening; LVMI, left ventricular mass index; Peak E, peak early diastolic flow velocity; peak A, peak late diastolic flow velocity; E/A ratio, ratio of early to late diastolic flow; DT deceleration time of E wave; LVIRT, left ventricular isovolumetric relaxation time.