Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymes activities

Table 5 Effect of experimental hypothyroidism on oxidative stress markers.

Ref.	Specie	MHI	Change in oxidative stress markers
9	Rat	HTX	↔ MDA and ↑ GSH in renal cortex.
50	Rat	PTU	↑ Brain total antioxidant status.
51	Rat	PTU	↓ MDA and GSH levels in cerebral, hepatic and cardiac tissues.
52	Rat	PTU	↓ Advanced glycation end-products and MDA-lysine in liver.
53	Rat	HTX	↑ GSH and ↓ MDA levels in liver.
54	Rat	PTU	↑ MDA in plasma, erythrocytes, and liver tissue. ↔ MDA in kidney. ↔ GSH levels of kidney and liver.
55	Rat	MMI	↔ Brain TBARS.
56	Mouse	PTU	↔ LPx and GSH, GSSG and GSSG/GSH ratio in skeletal muscle.
47	Rat	PTU	↓ TBARS in extensor digitorum longus muscle. ↔ TBARS in heart, liver, and soleus muscle.
57	Rat	PTU	↓ MDA and GSH in renal and testicular tissue.

Ref. = reference, MHI = Method of hypothyroidism induction, HTX = Thyroidectomized, PTU = 6-n-propyl-2-thiouracil, MMI = Methimazole, ↑ = increase, ↓ = decrease, ↔ = without change, LPx = lipid peroxidation, MDA = malondialdehyde, GSH = reduced glutathione, GSSG = oxidized glutathione, TBARS = Thiobarbituric acid reactive substances.

ISSN: 1471-2369