Table 3 Summary of the main findings of this study
HK-2 | WT9-7 | WT9-12 | |
|---|---|---|---|
Pattern of serum-induced proliferation | Increased in a time-dependent manner | Same pattern as HK-2 cells | Same pattern as HK-2 cells |
Effect of PDTC on proliferation | Reduced at 4-24 h | Reduced at 8-24 h | Reduced at 24 h |
Endogenous NF-κB reporter activity | High | Moderate | Low |
Effect of exogenous LPS on NF-κB reporter activity | Increased | No change | No change |
Effect of exogenous TNF-α on NF-κB reporter activity | Increased | Increased | Increased |
Effect of PDTC on TNF-α-induced NF-κB reporter activity | Reduced | No change | No change |
Effect of PDTC on TNF-α-induced nuclear NF-κB protein levels | Reduced p50 | Reduced p50 | Reduced p50 |
Effect of exogenous LPS and TNF-α on proliferation at 4 h and 24 h | Same as unstimulated cells | Same as unstimulated cells | Same as unstimulated cells |