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Table 3 Comparison of characteristic of hypovolaemic, euvolaemic and hypervolaemic groups

From: The role of natriuretic peptides in volume assessment and mortality prediction in Haemodialysis patients

 

Hypovolaemic

<95 % ideal ECF

Euvolaemic Ideal ECF ± 5 %

Hypervolaemic

>105 % ideal ECF

p-value

Number

36

45

89

 

Demographic, clinical & laboratory factors

Age (years)

63 ± 12

64 ± 14

c68 ± 13

0.085

% Male

56

71

71

NS

% White

d67

82

c92

0.002

Weight (kg)

d82 ± 20

75 ± 13

a,c70 ± 13

<0.001

Dialysis Vintage (months)

30 (34)

44 (46)

44 (53)

0.079

Diabetes (%)

39

22

24

NS

Cardiac History (%)

50

49

42

NS

Charlson Comorbidity Index

5.5 ± 2.3

5.5 ± 2.2

5.9 ± 2.0

NS

Haemoglobin (g/l)

116 ± 11

121 ± 13

a,c114 (15)

0.023

Serum albumin (g/l)

35.4 ± 5.4

36.5 ± 3.5

35.1 ± 4.7

NS

CRP > 5 mg/l

b58

31

a52

0.029

Serum sodium <136 mmol/l (%)

d47

29

27

0.079

KRU (ml/min)

d0.80 (2.66)

0.34 (1.77)

c0.04 (0.93)

0.011

Kt/V

1.32 ± 0.24

1.32 ± 0.25

1.29 ± 0.21

NS

Clinical assessment of volume status

Post-dialysis systolic BP (mmHg)

d127 ± 20

135 ± 26

c141 ± 27

0.016

Lung Crepitations (%)

42

53

60

NS

Elevated JVP (>3 cm) (%)

d19

29

a,c51

0.002

Oedema (%)

42

24

41

NS

Natriuretic peptide levels

ANP (pre-dialysis) (pmole/l)

147 (138)

149 (211)

c195 (274)

0.040

ANP (pre-dialysis) < 150 mmole/l (%)

53

53

a,c35

0.056

ANP (post-dialysis) (pmole/l)

62 (65)

62 (101)

c97 (116)

0.079

ANP (post-dialysis) < 100 pmole/l (%)

78

64

c51

0.015

BNP (pmole/l)

d228 (564)

268 (681)

a,c495 (1349)

0.003

BNP < 100 pmole/l (%)

25

33

a,c6

<0.001

Ultrafiltration characteristics

Ultrafiltration volume (l)

1.35 (1.50)

1.70 (1.20)

1.80 (1.55)

NS

Ultrafiltration rate (ml/kg/h)

d6.2 ± 4.2

7.6 ± 4.3

c8.5 ± 5.1

0.046

  1. The p-value refers to the significance of difference across the three groups by one-way ANOVA or the Kruskal Wallis test or Chi-square test as appropriate. a refers to a significant difference between hypervolaemic and euvolaemic groups. b refers to significance difference between hypovolaemic and euvolaemic groups. c refers to a significant difference between hypervolaemic group and the other two groups combined, d refers to a significant difference between hypovolaemic group and the other two groups combined