| Hypovolaemic <95 % ideal ECF | Euvolaemic Ideal ECF ± 5 % | Hypervolaemic >105 % ideal ECF | p-value |
---|---|---|---|---|
Number | 36 | 45 | 89 | Â |
Demographic, clinical & laboratory factors | ||||
Age (years) | 63 ± 12 | 64 ± 14 | c68 ± 13 | 0.085 |
% Male | 56 | 71 | 71 | NS |
% White | d67 | 82 | c92 | 0.002 |
Weight (kg) | d82 ± 20 | 75 ± 13 | a,c70 ± 13 | <0.001 |
Dialysis Vintage (months) | 30 (34) | 44 (46) | 44 (53) | 0.079 |
Diabetes (%) | 39 | 22 | 24 | NS |
Cardiac History (%) | 50 | 49 | 42 | NS |
Charlson Comorbidity Index | 5.5 ± 2.3 | 5.5 ± 2.2 | 5.9 ± 2.0 | NS |
Haemoglobin (g/l) | 116 ± 11 | 121 ± 13 | a,c114 (15) | 0.023 |
Serum albumin (g/l) | 35.4 ± 5.4 | 36.5 ± 3.5 | 35.1 ± 4.7 | NS |
CRP > 5 mg/l | b58 | 31 | a52 | 0.029 |
Serum sodium <136Â mmol/l (%) | d47 | 29 | 27 | 0.079 |
KRU (ml/min) | d0.80 (2.66) | 0.34 (1.77) | c0.04 (0.93) | 0.011 |
Kt/V | 1.32 ± 0.24 | 1.32 ± 0.25 | 1.29 ± 0.21 | NS |
Clinical assessment of volume status | ||||
Post-dialysis systolic BP (mmHg) | d127 ± 20 | 135 ± 26 | c141 ± 27 | 0.016 |
Lung Crepitations (%) | 42 | 53 | 60 | NS |
Elevated JVP (>3Â cm) (%) | d19 | 29 | a,c51 | 0.002 |
Oedema (%) | 42 | 24 | 41 | NS |
Natriuretic peptide levels | ||||
ANP (pre-dialysis) (pmole/l) | 147 (138) | 149 (211) | c195 (274) | 0.040 |
ANP (pre-dialysis) < 150 mmole/l (%) | 53 | 53 | a,c35 | 0.056 |
ANP (post-dialysis) (pmole/l) | 62 (65) | 62 (101) | c97 (116) | 0.079 |
ANP (post-dialysis) < 100 pmole/l (%) | 78 | 64 | c51 | 0.015 |
BNP (pmole/l) | d228 (564) | 268 (681) | a,c495 (1349) | 0.003 |
BNP < 100 pmole/l (%) | 25 | 33 | a,c6 | <0.001 |
Ultrafiltration characteristics | ||||
Ultrafiltration volume (l) | 1.35 (1.50) | 1.70 (1.20) | 1.80 (1.55) | NS |
Ultrafiltration rate (ml/kg/h) | d6.2 ± 4.2 | 7.6 ± 4.3 | c8.5 ± 5.1 | 0.046 |