Table 1 Basal biochemistry and echocardiography

Body weight [g]

20.2 ± 0.7

18.6 ± 1.6

30.1 ± 6.4

26.4 ± 4.2

Serum parameter

 Urea [mmol/l]

10.8 ± 3.3

11.6 ± 1.9

6.6 ± 1

6.0 ± 0.9

 Creatinine [μmol/l]

19.6 ± 2.1

24.5 ± 8.6

18.0 ± 5.9

26.2 ± 16.7

 Calcium [mmol/l]

2.48 ± 0.10

2.23 ± 0.08

2.39 ± 0.13

2.39 ± 0.09

 Phosphate [mmol/l]

3.11 ± 0.91

3.05 ± 0.82

2.88 ± 0.45

2.85 ± 0.34

 Protein [g/dl]

4.46 ± 0.74

4.90 ± 0.15

6.00 ± 0.42

5.50 ± 0.26*

 Alkaline phosphatase [U/l]

255 ± 106

256 ± 35

142 ± 54

207 ± 69

 ucMGP [nM]

3158 ± 458

2987 ± 554

3523 ± 1645

3532 ± 1095

 Protein S [ng/ml]

0.97 ± 0.24

0.87 ± 0.16

0.80 ± 0.14

0.72 ± 0.14

Echocardiography

 Left ventricular mass [mg]

50.8 ± 11.4

73.6 ± 9.8*

98.6 ± 15.2

81.8 ± 29.5

 Stroke volume [μl]

23.9 ± 9.0

20.3 ± 6.3

23.6 ± 6.2

19.8 ± 4.3

 Ejection Fraction [%]

54.3 ± 11

45.6 ± 7.8

40.1 ± 9.6

41.5 ± 11.0

 VACC [mm/ms]

2.09 ± 0.98

2.06 ± 1.15

2.13 ± 1.52

1.72 ± 0.72