Isolated diplopia associated with calcineurin inhibitor therapy in a patient with idiopathic membranous nephropathy: a case report

Table 1 Cases reported in literature presenting with eye movement disorders in the setting of calcineurin inhibitor therapy

Study Title and author	Age/Sex	Diagnosis	Drug name	Days after treatment	Route of administration	Drug level	Neurological Deficit
Openshaw, Slatkin et al. 1997 [4]		Post bone marrow transplant for Acute Lymphocytic Leukemia	Cyclosporin	72	Per Oral	475 ng/ml	Unilateral six nerve palsy
Case 1	16/Female	Post bone marrow transplant for Acute Lymphocytic Leukemia	Cyclosporin	72	Per Oral	475 ng/ml	Unilateral six nerve palsy
Case 2	37/Female	Post bone marrow transplant for Acute Lymphocytic Leukemia	Cyclosporin	73	Per Oral	1356 ng/ml	Ptosis, bilateral sixth nerve palsy
Case 3	18/Female	Acute Leukemia Mixed lineage	Cyclosporin	47	Intravenous	700 ng/ml	Ptosis, bilateral sixth nerve palsy encephalopathy
Case 4	20/Female	Chronic Myelogenous Leukemia	Cyclosporin	80	Intravenous	Not Reported	Ptosis, bilateral sixth nerve palsy encephalopathy seizure
Lai, Kerrison et al. 2004 [2]	50/Male	Post orthotopic cardiac transplant	FK506	93	Intravenous	10–20 ng/dl	Worsening headache horizontal diplopia, Bilateral Inter nuclear opthalmoplegia
Oliverio, Restrepo et al. 2000 [3]	30/female	Post bone marrow transplant for chronic myeloid leukemia	FK506	84	Per Oral	Reported as within therapeutic range	Diplopia, horizontal nystagmus, and bilateral sixth nerve palsy. visual hallucinations

ISSN: 1471-2369