Initial | 2-week placebo | p-value | |
Serum Bicarbonate (mEq/L) | 23.0 ± 2.3 | 22.2 ± 2.8 | 0.17 |
FGF23 (RU/mL) | 157.4 (90.2–289.4) | 161.7 (104.5–245.5) | 0.91 |
Before sodium bicarbonatea | After sodium bicarbonate | p-value | |
Systolic blood pressure (mmHg) | 131 ± 11 | 130 ± 14 | 0.71 |
Diastolic blood pressure (mmHg) | 69 ± 8 | 70 ± 10 | 0.66 |
Serum Bicarbonate (mEq/L) | 22.6 ± 2.3 | 25.5 ± 2.2 | < 0.001 |
eGFR (ml/min per 1.73 m2) | 40.6 ± 15.6 | 40.0 ± 15.1 | 0.65 |
FGF23 (RU/mL) | 150.9 (107.7–267.43) | 191.4 (132.6–316.9) | 0.048 |
25-OH vitamin D (ng/mL) | 36 ± 13 | 37 ± 14 | 0.60 |
1, 25-OH vitamin D (pg/mL)c | 42 (21–58) | 42 (18–57) | 0.79 |
Serum calcium (mg/dL) | 9.9 ± 0.5 | 9.9 ± 0.5 | 0.39 |
Serum phosphate (mg/dL) | 4.0 ± 0.8 | 3.9 ± 0.8 | 0.31 |
Urine calcium (mg/mg Cr)b | 0.03 (0.02–0.04) | 0.01 (0.01–0.05) | 0.09 |
Urine phosphate (mg/mg Cr)b | 0.47 (0.28–0.61) | 0.42 (0.32–0.55) | 0.84 |
Urine sodium (mg/mg Cr)b | 2.4 ± 0.7 | 2.8 ± 1.0 | 0.07 |
Fractional excretion of phosphate (%) | 18 (14–24) | 21 (15–26) | 0.22 |
Fractional excretion of sodium (%) | 1.4 (1.1–2.4) | 1.6 (1.1–2.2) | 0.44 |