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Table 4 Associations between different albumin categories using 2-year serum albumin measurements with all-cause and cardiovascular mortality in the study population

From: An association between time-varying serum albumin level and the mortality rate in maintenance haemodialysis patients: a five-year clinical cohort study

Albumin category

All-cause mortality

Unadjusted

Adjusted

Adjusted

(demographic)

HR

95 % CI

P

HR

95 % CI

P

HR

95 % CI

P

Albumin rate reached 3.5 (g/dL)

 100 %

Reference

Reference

Reference

 75 to < 100 %

2.41

1.70–3.43

<0.001

2.01

1.41–2.87

<0.001

1.72

1.19–2.47

0.004

 50 to < 75 %

5.82

3.61–9.37

<0.001

3.64

2.22–5.95

<0.001

3.14

1.91–5.16

<0.001

 1 to < 50 %

7.20

4.43–11.69

<0.001

4.95

3.00–8.16

<0.001

3.66

2.18–6.16

<0.001

 0

8.10

3.25–20.14

<0.001

4.80

1.90–12.15

0.001

2.54

0.96–6.76

0.062

Albumin rate reached 3.5 (g/dL)

 Higher rate (75–100 %)

Reference

Reference

Reference

 Lower rate (0– < 75 %)

4.45

3.22–6.14

<0.001

3.11

2.23–4.35

<0.001

2.55

1.79–3.63

<0.001

Time-averaged serum albumin

 ≥4

Reference

Reference

Reference

 3.5 to < 4

2.38

1.54–3.68

<0.001

1.80

1.15–2.81

0.010

1.57

1.00–2.46

0.051

 <3.5

8.71

5.28–14.37

<0.001

4.84

2.84–8.26

<0.001

3.66

2.11–6.32

<0.001

Albumin rate reached 3.5 (g/dL)

 100 %

Reference

Reference

Reference

 75 to < 100 %

2.32

1.18–4.54

0.015

1.99

1.01–3.93

0.046

1.73

0.86–3.48

0.124

 50 to < 75 %

7.88

3.53–17.58

<0.001

4.78

2.09–10.96

<0.001

4.28

1.82–10.01

0.001

 1 to < 50 %

7.75

3.23–18.62

<0.001

4.69

1.91–11.49

0.001

3.23

1.22–8.54

0.018

 0

10.38

2.40–44.91

0.002

6.59

1.47–29.61

0.014

4.08

0.86–19.39

0.077

Albumin category

Cardiovascular mortality

Unadjusted

Adjusted

Adjusted

(demographic)

HR

95 % CI

P

HR

95 % CI

P

HR

95 % CI

P

Albumin rate reached 3.5 (g/dL)

 Higher rate (75–100 %)

Reference

Reference

Reference

 Lower rate (0– < 75 %)

5.88

3.31–10.45

<0.001

3.66

2.01–6.68

<0.001

2.94

1.58–5.47

0.001

Time-averaged serum albumin

 ≥4

Reference

Reference

Reference

 3.5 to < 4

2.02

0.93–4.42

0.076

1.51

0.68–3.36

0.315

1.28

0.57–2.90

0.552

 <3.5

8.94

3.74–21.37

<0.001

4.61

1.82–11.63

0.001

3.24

1.23–8.56

0.018

  1. Univariate and multivariate Cox proportional hazard regression model
  2. Adjusted (demographic), the adjusted covariates including dialysis vintage, age, sex, and diabetes mellitus
  3. Adjusted, the adjusted covariates including dialysis vintage, age, sex, diabetes mellitus, and all laboratory blood analysis values