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Table 3 Risk factors associated with death and dialysis initiation (univariable analyses)

From: Competing risk of death and end-stage renal disease in incident chronic kidney disease (stages 3 to 5): the EPIRAN community-based study

 

Cox model

Fine-Gray model

Variables

Death

Dialysis initiation

Death

Dialysis initiation

 

HR

95 % CI

HR

95 % CI

HR

95 % CI

HR

95 % CI

Age (years)

  < 70

1.00

 

1.00

 

1.00

 

1.00

 

 70–80

1.91

[1.23 –2.97]

0.44

[0.23 –0.84]

2.07

[1.34 –3.22]

0 .39

[0.21 –0.75]

 80–85

1.87

[1.15 –3.03]

0.30

[0.13 –0.74]

2.06

[1.28 –3.33]

0 .27

[0.11 –0.66]

  > 85

2.78

[1.8 –4.32]

0.45

[0.22 –0.92]

2.98

[1.92 –4.62]

0.36

[0.17 –0.73]

Gender

 Male

1.00

 

1.00

 

1.00

 

1.00

 

 Female

1.13

[0.84 –1.52]

1.37

[0.81 –2.32]

1.10

[0.82 –1.49]

1.27

[0.75 –2.15]

Hemoglobin

  ≥ 11 g/dL

1.00

 

1.00

 

1.00

 

1.00

 

  < 11 g/dL

2.37

[1.76 –3.17]

2.52

[1.44 –4.41]

2.13

[1.59 –2.86]

1.89

[1.09 –3.29]

Cancer < 5 years

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

1.67

[1.18 –2.35]

0.95

[0.45 –2.01]

1.62

[1.14 –2.32]

0.78

[0.37 –1.67]

Chronic heart failure

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

1.74

[1.29 –2.36]

0.68

[0.33 –1.38]

1.78

[1.32 –2.4]

0.59

[0.29 –1.19]

Ischemic cardiopathy

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

1.28

[0.95 –1.72]

0.80

[0.44 –1.43]

1.30

[0.97 –1.74]

0.75

[0.42 –1.34]

Stroke

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

1.45

[0.94 –2.25]

0.57

[0.18 –1.84]

1.48

[0.96 –2.3]

0.52

[0.16 –1.68]

Peripheral arterial disease

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

1.07

[0.76 –1.52]

1.55

[0.87 –2.75]

1.03

[0.73 –1.44]

1.59

[0.9 –2.81]

Diabetes

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

0.92

[0.68 –1.25]

2.54

[1.51 –4.28]

0.88

[0.65 –1.18]

2.62

[1.56 –4.41]

High blood pressure

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

0.82

[0.6 –1.11]

0.85

[0.48 –1.5]

0.85

[0.62 –1.15]

0.90

[0.51 –1.58]

Others

 No

1.00

 

1.00

 

1.00

 

1.00

 

 Yes

1.56

[0.96 –2.53]

1.18

[0.54 –2.61]

1.54

[0.94 –2.52]

1.08

[0.49 –2.39]

eGFR

  > 20 mL/min

1.00

 

1.00

 

1.00

 

1.00

 

  < 20 mL/min

1.30

[0.77 –2.2]

6.93

[3.96 –12.13]

0.85

[0.49 –1.48]

6.04

[3.39 –10.74]

  1. X variables entered into the multivariable analyses
  2. CI confidence interval, eGFR estimated glomerular filtration rate using MDRD formula (Modification of the Diet in Renal Disease), HR hazard ratio