Table 2 Comparison of clinical, echocardiographic features and biochemical data before and after 3 year follow-up

eGFR(ml/min/1.73 m²)

>90

69.0(54.0–78.0)

65.0(44.0–75.0)

<0.001

BMI (kg/m²)

20–24

24.67 ± 2.78

24.98 ± 2.47

0.212

Calcium (mg/dl)

8.8–10.2

8.27 ± 0.45

8.19 ± 0.31

0.039

Sodium (mmol/L)

(135–144)

139.48 ± 4.22

137.59 ± 3.62

0.066

Phosphorus (mg/dl)

2.5–4.5

4.80(4.13–5.30)

5.70(4.80–8.20)

<0.001

HDL Cholesterol (mg/dl)

45–65

43(39.0–46.0)

45.0(40.25–47.00)

0.003

LDL Cholesterol (mg/dl)

100–130

123(118–129)

128(109–139)

0.005

Total Cholesterol (mg/dl)

70–200

193.71 ± 15.02

194.05 ± 16.44

0.843

Triglyceride (mg/dl)

40–130

140.37 ± 11.41

134.46 ± 11.19

<0.001

Hemoglobin (g/l)

12–16

14.0(12.8–14.7)

13.6(13.1–14.0)

0.002

Glucose (mg/dl)

82–115

85.0(78–120)

88(80–115)

0.001

Urine volume (mL)

-

1868 ± 572

1780 ± 568

<0.001

U-osmolarity (mOsm/kg)

-

205(178–245)

289(254–395)

<0.001

Average 24-h systolic BP, mmHg

<130

135 ± 6.9

142 ± 7.2

<0.001

Average 24-h diastolic BP, mmHg

<80

83 ± 4.8

86 ± 5.3

<0.001

Proteinuria (mg/day)

0–150

1100 (500–1870)

1540 (720–2600)

<0.001

Left ventricular ejection fraction(%)

>55

64.4 ± 5.0

62.1 ± 5.8

0.245

Left ventricular mass (g)

49–115

169.4 ± 37.3

171.3 ± 46.5

0.311

Left ventricular end-diastolic diameter (mm)

42–59

46.5 ± 2.9

47.0 ± 3.4

0.175

PWV (m/sec)

-

8.10 ± 1.20

8.24 ± 1.34

0.044

FMD, %

-

6.92 ± 0.87

5.78 ± 0.92

<0.001

CIMT(mm)

-

0.72 ± 0.11

0.82 ± 0.08

<0.001

Copeptin (ng/mL)

N/A

0.62 ± 0.12

0.94 ± 0.19

<0.001

Hs-CRP (mg/l)

<0.2

3.40(2.20–4.0)

9.00(5.10–19.0)

<0.001