Parameter | Controls n = 18 | CKD n = 51 | P value |
---|---|---|---|
Sex M/F | 7/11 | 20/31 | NS |
Age, years | 47.4 ± 6.18 | 53.3 ± 15.5 | NS |
BMI, kg/m2 | 25.83 ± 3.45 | 24.2 ± 3.55 | NS |
eGFR, mL/min/1.73 m2 | 117.0 (105.0 – 125.0) | 20.6 (5.6 - 127) | 0.0001 |
Creatinine, mg/dL | 0.88 (0.34 – 1.18) | 3.32 (0.78 – 9.33) | 0.0001 |
Urea, mg/dL | 30.03 ± 6.05 | 118 ± 53.1 | 0.0001 |
hs-CRP, μg/ml | 0.42 (0.01 – 9.25) | 3.38 (0.01 - 94) | 0.0079 |
Neopterin, nmol/L | 5.93 (0.41 – 12.9) | 32 (5 – 150) | 0.0001 |
Cu/Zn SOD, ng/ml | 51 (6 – 78) | 62 (30 – 262) | 0.0372 |
H2O2, μM | 55.2 (2.33 – 434) | 243 (60.7 – 624) | 0.0012 |
Glucose, mmol/L | 92.1 (67–114) | 90 (45–186) | NS |
Total cholesterol, mg/dL | 192 (143–248) | 199 (106–485) | NS |
Triglycerides, mg/dL | 67 (38–149) | 152 (61–620) | 0.0001 |
Total protein, g/dL | 6.36 (6.08 – 7.1) | 6 (3.2 – 7.8) | 0.0261 |
Albumin, g/dL | 4.43 (4.11 – 4.98) | 3.3 (0.9 – 8.9) | 0.0001 |
Red blood cells, ×103 μL | 4.55 ± 0.31 | 3.59 ± 0.69 | 0.0001 |
White blood cells, ×103 μL | 5.77 ± 1.09 | 6.38 ± 1.98 | NS |
Lymphocytes, % | 33.1 ± 5.38 | 27 ± 9.85 | 0.0107 |
Platelets, ×103 μL | 206 (132.0 – 310.0) | 184 (76–482) | NS |
Neutrophils, % | 59.19 ± 6.424 | 59.4 ± 13.1 | NS |
Hemoglobin, g/dL | 14.18 ± 1.3 | 11.1 ± 2.31 | 0.0001 |
Hematocrit, % | 42 ± 3.1 | 33.2 ± 6.15 | 0.0001 |
Bilirubin, mg/dL | 0.34 ± 0.13 | 0.48 ± 0.22 | 0.0157 |
ALT, U/L | 34.5 (16 – 53) | 28 (10–130) | NS |
Smokers, % | 20.00 | 22.65 | NS |
Pharmacotherapy (%) | |||
Cardiovascular Disease (CVD) | 45.28 | ||
ACE-inhibitors | 49.00 | ||
Ca2+ blockers | 56.50 | ||
β-blockers | 41.50 | ||
α-blockers | 7.50 | ||
Nitrates | 5.50 | ||
ARBs | 4.00 |