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Table 2 Characteristics and outcomes according to the treatments in patients with nephrotic syndrome

From: Factors affecting the long-term outcomes of idiopathic membranous nephropathy

 

Conservative management (N = 30)

Oral corticosteroid (N = 22)

Oral corticosteroid + cyclophosphamide (N = 100)

Oral corticosteroid + cyclosporine (N = 14)

Agea (years)

51

47

57

44

SBP (mmHg)

128

125

130

135

Proteinuriaa(g/g creatinine)

6.43

6.95

8.93

8.53

Serum Albumina(g/dL)

2.8

2.5

2.3

2.3

Serum creatinine (mg/dl)

0.91

0.93

1.03

0.92

Total cholesterola(mg/dl)

277

354

354

321

Treatments

 RAAS blockers

26 (86.7%)

13 (59.1%)

75 (75%)

12 (85.7%)

 Anti-HTN

13 (43.3%)

11 (50%)

51 (51%)

7 (50%)

 Statin

22 (73.3%)

10 (45.5%)

79 (79%)

12 (85.7%)

Remission

26 (86.7%)

17 (77.2%)

73 (73%)

9 (64.3%)

Relapse

2/26 (7.7%)

3/17 (17.6%)

16/73 (21.9%)

5/9 (55.6%)

Persistence

4 (13.4%)

5 (22.8%)

27 (27%)

5 (35.7%)

End pointsb

2 (6.7%)

4 (18.2%)

13 (13%)

3 (21.4%)

  1. Data are presented as mean, number (% of total)
  2. a P < 0.01, Difference between groups; RAAS blockers Renin-angiotensin-aldosterone system blockers, Anti-HTN Anti-hypertensive medication
  3. bEnd points include doubling of serum creatinine concentration compared to baseline level and development of end stage renal disease