Characteristics | Model from primary analysisa OR (95% CI) | P valueb (PT) | Sensitivity analysis Odds Ratioa (95% confidence interval) | P valueb (PT) | |
---|---|---|---|---|---|
Females |  | 0.64 (0.49–0.83) | 0.0008 | 0.63 (0.49–0.80) | 0.0002 |
Age categories years | 65–69 | 0.83 (0.52–1.35) | 0.55 | 1.00 (0.65–1.54) | 0.52 |
70–74 | 0.70 (0.46–1.09) |  | 0.75 (0.50–1.11) |  | |
75–79 | 0.78 (0.54–1.13) |  | 0.82 (0.58–1.15) |  | |
80–84 | 0.84 (0.59–1.18) |  | 0.90 (0.66–1.23) |  | |
≥85 | 1 |  | 1 |  | |
Smoking status | Non-smoker | 1 | 0.25 | 1 | 0.32 |
Current smoker | 1.39 (0.92–2.11) |  | 1.32 (0.91–1.92) |  | |
Ex-smoker | 1.26 (0.91–1.74) |  | 1.19 (0.89–1.59) |  | |
Alcohol intake (units/day) | Non-drinker | 1 | 0.43 | 1 | 0.18 |
Ex-drinker | 1.00 (0.64–1.55) |  | 1.17 (0.78–1.76) |  | |
Current ≤6 units/day | 0.88 (0.61–1.26) |  | 0.99 (0.71–1.39) |  | |
Heavy >6 units/day | 0.55 (0.24–1.26) |  | 0.54 (0.25–1.16) |  | |
BMI (kg/m2) | 15–18.4 | 0.95 (0.45–2.00) | 0.53 | 0.80 (0.40–1.61) | 0.28 |
18.5–24.9 | 1 |  | 1 |  | |
25–29.9 | 0.90 (0.65–1.23) |  | 0.84 (0.63–1.11) |  | |
≥30 | 1.14 (0.82–1.58) |  | 1.10 (0.81–1.47) |  | |
eGFR (mL/min/1.73m2) | ≤29 | 4.62 (3.06–6.99) | <0.0001 | 4.86 (3.34–7.09) | <0.0001 |
30–59 | 2.48 (1.84–3.33) | (<0.0001) | 2.47 (1.89–3.23) | (<0.0001) | |
≥60 | 1 |  | 1 |  | |
Proteinuria |  | 1.23 (0.95–1.59) | 0.12 | 1.22 (0.96–1.54) | 0.10 |
Hypertension |  | 1.27 (0.93–1.73) | 0.13 | 1.19 (0.90–1.57) | 0.21 |
Congestive cardiac failure |  | 1.03 (0.76–1.39) | 0.86 | 1.05 (0.80–1.39) | 0.71 |
Ischaemic heart disease |  | 0.76 (0.58–1.00) | 0.04 | 0.77 (0.60–0.98) | 0.03 |
Cerebrovascular disease |  | 0.90 (0.68–1.20) | 0.47 | 0.81 (0.62–1.05) | 0.10 |
Dementia |  | 1.17 (0.73–1.88) | 0.53 | 1.17 (0.76–1.82) | 0.48 |
Chronic lung disease |  | 0.79 (0.58–1.07) | 0.12 | 0.75 (0.57–0.98) | 0.03 |
Cancer |  | 0.76 (0.54–1.07) | 0.11 | 0.89 (0.66–1.19) | 0.42 |
Connective tissue diseases |  | 0.66 (0.40–1.08) | 0.08 | 0.73 (0.47–1.12) | 0.14 |
Either ACEI/ ARBs |  | 1.59 (1.19–2.13) | 0.002 | 1.48 (1.14–1.92) | 0.003 |
Glycated haemoglobin levels | Good <7% | 1 | Â | 1 | Â |
Borderline 7–10% | 0.82 (0.62–1.09) | 0.38 | 0.85 (0.66–1.10) | 0.42 | |
High >7% | 0.82 (0.43–1.54) |  | 1.03 (0.60–1.77) |  | |
Medication-diabetes | None | 1 | Â | 1 | Â |
Oral | 1.05 (0.75–1.46) | 0.05 | 1.02 (0.75–1.38) | 0.02 | |
Insulin | 2.27 (1.27–4.05) |  | 2.27 (1.34–3.84) |  | |
Both | 1.11 (0.72–1.71) |  | 1.10 (0.74–1.62) |  | |
Study period | April 2004–September 2007 | 1 | <0.0001 | 1 | <0.0001 |
October 2007–March 2011 | 2.90 (2.14–3.95) | (<0.0001) | 2.38 (1.83–3.10) | (<0.0001) |