Table 1 Patient characteristics
Total cohort n = 205 | MPP ≤59 mmHg n = 105 | MPP >59 mmHg n = 100 | p-value | |
|---|---|---|---|---|
Age, median (IQR) | 70 (56–77) | 71 (56–78) | 70 (57–78) | 0.66 |
Male gender, n (%) | 138 (67.3) | 72 (68.6) | 66 (66.0) | 0.70 |
Comorbidities | ||||
IHD / CHF, n (%) | 90 (43.9) | 45 (42.9) | 45(45.0) | 0.76 |
Diabetes, n (%) | 38 (18.5) | 17 (16.2) | 21 (21.0) | 0.38 |
Hypertension, n (%) | 79 (38.5) | 35 (33.3) | 44 (44.0) | 0.12 |
CKD, n (%) | 25 (12.2) | 12 (11.4) | 13 (13.0) | 0.73 |
COPD, n (%) | 26 (12.7) | 11 (10.5) | 15 (15.0) | 0.33 |
CLD, n (%) | 11 (5.4) | 6 (5.7) | 5 (5.0) | 0.82 |
Admission diagnosis | ||||
Post-surgical, n (%) | 72 (35.1) | 34 (23.3) | 38 (38.0) | 0.88 |
Cardiac emergency, n (%) | 53 (25.9) | 29 (27.6) | 24 (24.0) | |
Sepsis, n (%) | 35 (17.1) | 18 (17.1) | 17 (17.0) | |
Respiratory emergency, n (%) | 34 (16.6) | 17 (16.2) | 17 (17.0) | |
Gastrointestinal emergency, n (%) | 7 (3.4) | 5 (4.8) | 2 (2.0) | |
Other, n (%) | 3 (1.5) | 1 (1.0) | 2 (2.0) | |
Parameters on admission to ICU | ||||
SOFA score, mean (SD) | 7.1 (2.8) | 7.5 (2.6) | 6.8 (2.9) | 0.09 |
APACHE II score, median (IQR) | 18 (14–21) | 17 (14–21) | 18 (13–21) | 0.80 |
Parameters on day of AKI I | ||||
SOFA score, mean (SD) | 8.7 (2.7) | 9.2 (2.7) | 8.1 (2.7) | 0.003 |
Cumulative fluid balance [ml], median (IQR) | 2363 (52–3812) | 2149 (802–3643) | 2568 (994–4116) | 0.234 |
Sepsis, n (%) | 122 (59.8) | 57 (54.8) | 65 (65) | 0.138 |
Parameters within 12 h of diagnosis of AKI I | ||||
DO2I [ml/min/m2], median (IQR) | 362 (277–4836) | 347 (270–459) | 377 (296–494) | 0.132 |
Arterial lactate [mmol/L], median (IQR) | 1.7 (1.3–2.6) | 1.8 (1.2–2.6) | 1.7 (1.3–2.6) | 0.833 |
MAP <65 mmHg for >1 h, n (%) | 107 (52.2) | 74 (70.5) | 33 (33.0) | <0.001 |
MAP during 12 h [mmHg], median (IQR) | 73 (69–78) | 69 (66–73) | 78 (73–83) | <0.001 |
CVP [mmHg], median (IQR) | 14 (10–18) | 14 (11–18) | 11 (9–15) | <0.001 |
Vasopressor use, n (%) | 182 (88.8) | 99 (94.3) | 83 (83.0) | 0.01 |