Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients – a prospective study

Table 1 Differences in all-cause mortality by T helper cell cytokine genes in hemodialysis patients

Tested polymorphism	N	Major homozytes vs. heterozygotes vs. minor homozygotes^a	Dominant model of inheritance^b	Recessive model of inheritance^b	Additive model of inheritance^b
CCL2 rs1024611	261	AA vs. AG vs. GG P = 0.848	GG + AG vs. AA P = 0.363	GG vs. AG + AA P = 0.777	GG vs. AA P = 0.601
IFNL3 rs8099917	265	TT vs. GT vs. GG P = 0.139	GG + GT vs. TT P = 0.688	GG vs. GT + TT P = 0.044^c	GG vs. TT P = 0.052
IFNL3 rs12979860	266	CC vs. CT vs. TT P = 0.394	TT + CT vs. CC P = 0.896	TT vs. CT + CC P = 0.490	TT vs. CC P = 0.640
IL4R rs1805015	294	TT vs. CT vs. CC P = 0.829	CC + CT vs. TT P = 0.703	CC vs. CT + TT P = 0.352	CC vs. TT P = 0.348
IL12A rs568408	297	GG vs. AG vs. AA P = 0.034	AA + AG vs. GG P = 0.029^d	AA vs. AG + GG P = 0.816	AA vs. GG P = 0.958
IL12B rs3212227	297	AA vs. AC vs. CC P = 0.274	CC + AC vs. AA P = 0.163	CC vs. AC + AA P = 0.104	CC vs. AA P = 0.087
IL13 rs20541	293	CC vs. CT vs. TT P = 0.412	TT + CT vs. CC P = 0.189	TT vs. CT + CC P = 0.981	TT vs. CC P = 0.803
IL18 rs360719	316	TT vs. CT vs. CC P = 0.651	CC + CT vs. TT P = 0.260	CC vs. CT + TT P = 0.648	CC vs. TT P = 0.484

Abbreviations: CCL2 chemokine (C-C motif) ligand 2 gene, IFNL3 interferon lambda 3 gene, IL interleukin gene, IL4R interleukin 4 receptor gene, N number of deaths among tested patients
^aMultiple-sample test P
^bLog rank test P
^cThe test power = 0.98
^dThe test power = 0.66

ISSN: 1471-2369