From: Molecular differences in susceptibility of the kidney to sepsis-induced kidney injury
Baseline | 12 h | 18 h | 22 h | |
---|---|---|---|---|
Creatinine [umol/l] | ||||
NON-AKI | 99 [91–118] | 95 [79–115] | 98 [85–113] | 101 [93–119] |
AKI | 103 [97–110] | 111 [94–131] | 136 [117–164]*# | 163 [137–217]*# |
Renal Blood Flow [ml/min/kg] | ||||
NON-AKI | 6 [5–6] | 4 [3–7] | 5 [3–7] | 4 [3–5] |
AKI | 5 [4–8] | 3 [2–4] | 3 [1–5]* | 1 [0.5–2]*# |
Renal Vascular Resistance [mmHg/l/min] | ||||
NON-AKI | 422 [345–494] | 385 [314–461] | 320 [284–417] | 417 [358–465] |
AKI | 419 [321–637] | 782 [537–1003] | 1457 [567–2374] | 2433 [1400–3886]*# |
Renal cortical microcirculation (Laser Doppler Flowmetry) [% of baseline value] | ||||
NON-AKI | 100 [100–100] | 108 [66–116] | 100 [77–123] | 84 [52–110] |
AKI | 100 [100–100] | 50 [28–61]* | 50 [38–56]* | 40 [27–57]*# |