| Multivariate analysis |
---|
Variables | HR (95% CI) b | P |
---|
BAFFa | 1.94 (0.59–6.39) | 0.28 |
VEGFR-2a | 1.63 (0.70–3.77) | 0.26 |
MCP-1a | 1.88 (0.57–6.16) | 0.30 |
RANTESa | 0.99 (0.52–1.88) | 0.97 |
CXCL10a | 1.32 (0.44–3.96) | 0.63 |
CXCL16a | 1.61 (0.69–3.71) | 0.27 |
EGFa | 0.40 (0.17–0.95) | 0.04 |
Endocana | 1.60 (0.68–3.75) | 0.28 |
Endostatina | 1.37 (0.61–3.05) | 0.45 |
GDF-15a | 2.45 (1.01–5.94) | 0.048 |
IFNγa | 0.91 (0.53–1.58) | 0.75 |
IL-6a | 3.02 (1.05–8.64) | 0.04 |
MBLa | 1.92 (0.89–4.13) | 0.10 |
Nephrina | 1.03 (0.66–1.62) | 0.89 |
TfRa | 0.66 (0.17–2.55) | 0.55 |
KIM-1a | 1.85 (0.69–4.93) | 0.22 |
- BAFF, B-cell-activating factor; CI, confidence interval; CXCL10, C–X–C motif chemokine 10; CXCL16, C–X–C motif ligand 16; DM, diabetes mellitus; HTN, hypertension; EGF, epidermal growth factor; eGFR, estimated glomerular filtration rate; GDF-15, growth/differentiation factor-15; HR, hazard ratio; IFNγ, interferon γ; IL-6, interleukin-6; KIM-1, kidney injury molecule-1; MBL, mannose-binding lectin; MCP-1, monocyte chemoattractant protein-1; PCR, protein–creatinine ratio; RANTES, regulated on activation, normal T cell expressed and secreted; TfR, transferrin receptor; VEGFR-2, vascular endothelial growth factor receptor-2
- aBiomarker values are expressed relative to urine creatinine concentration and then log-transformed
- bMultivariate analysis was conducted by adjusting for age, sex, HTN, eGFR, and PCR for each biomarker separately