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  1. Research article

    Diagnosis and outcomes of acute kidney injury using surrogate and imputation methods for missing preadmission creatinine values

    Missing preadmission serum creatinine (SCr) values are a common obstacle to assess acute kidney injury (AKI) diagnosis and outcomes. The Kidney Disease Improving Global Outcomes (KDIGO) guidelines suggest usin...

    Amélie Bernier-Jean, William Beaubien-Souligny, Rémi Goupil, François Madore, François Paquette, Stéphan Troyanov and Josée Bouchard

    BMC Nephrology 2017 18:141

    Published on: 28 April 2017

  2. Case report

    Novel mutation in the SLC12A3 gene in a Sri Lankan family with Gitelman syndrome & coexistent diabetes: a case report

    Gitelman syndrome (GS) is a rare autosomal recessively inherited salt-wasting tubulopathy associated with mutations in the SLC12A3 gene, which encodes for NaCl cotransporter (NCC) in the kidney.

    Chandrika Jayakanthi Subasinghe, Nirmala Dushyanthi Sirisena, Chula Herath, Knut Erik Berge, Trond Paul Leren, Uditha Bulugahapitiya and Vajira Harshadeva Weerabaddana Dissanayake

    BMC Nephrology 2017 18:140

    Published on: 26 April 2017

  3. Study protocol

    Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients

    Preserved residual kidney function (RKF) and normal fluid status are associated with better patient outcomes in incident haemodialysis patients. The objective of this trial is to determine whether using bioimp...

    Simon J. Davies, Fergus J. Caskey, David Coyle, Elizabeth Lindley, Jamie Macdonald, Sandip Mitra, Martin Wilkie, Andrew Davenport, Ken Farrington, Indranil Dasgupta, Paula Ormandy, Lazaros Andronis, Ivonne Solis-Trapala and Julius Sim

    BMC Nephrology 2017 18:138

    Published on: 26 April 2017

  4. Case report

    A case report of severe calciphylaxis – suggested approach for diagnosis and treatment

    Calciphylaxis is a serious complication in patients with chronic kidney disease associated mineral and bone disorder. It can occur in conditions with low and high bone turnover. So far, there are no definite d...

    Margret Patecki, Gabriele Lehmann, Jan Hinrich Bräsen, Jessica Schmitz, Anna Bertram, Lars Daniel Berthold, Hermann Haller and Wilfried Gwinner

    BMC Nephrology 2017 18:137

    Published on: 21 April 2017

  5. Research article

    A comparative study of bone biopsies from the iliac crest, the tibial bone, and the lumbar spine

    Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These ‘chronic kidney disease – mineral and bone disorders’ (CKD-MBD) range from high turnover osteoporosis to a...

    Ruth G. G. Hiller, Margret Patecki, Claudia Neunaber, Janin Reifenrath, Jan T. Kielstein and Heike Kielstein

    BMC Nephrology 2017 18:134

    Published on: 13 April 2017

  6. Research article

    Seroprevalence of a “new” bacterium, Simkania negevensis, in renal transplant recipients and in hemodialysis patients

    Simkania negevensis is an obligate intracellular bacterium belonging to the family Simkaniaceae in the Chlamydiales order. It is considered an ubiquitous microorganism and aquatic envi...

    Andrea Angeletti, Roberta Biondi, Giuseppe Battaglino, Eleonora Cremonini, Giorgia Comai, Irene Capelli, Gabriele Donati, Roberto Cevenini, Manuela Donati and Gaetano La Manna

    BMC Nephrology 2017 18:133

    Published on: 13 April 2017

  7. Research article

    Implementation of a pragmatic randomized trial of screening for chronic kidney disease to improve care among non-diabetic hypertensive veterans

    Whether screening for chronic kidney disease (CKD) can improve the care of persons at high risk for complications remains uncertain. We describe the design and early implementation experience of a pilot, clust...

    Carmen A. Peralta, Martin Frigaard, Anna D. Rubinsky, Leticia Rolon, Lowell Lo, Santhi Voora, Karen Seal, Delphine Tuot, Shirley Chao, Kimberly Lui, Phillip Chiao, Neil Powe and Michael Shlipak

    BMC Nephrology 2017 18:132

    Published on: 12 April 2017

  8. Study protocol

    A programme to spread eGFR graph surveillance for the early identification, support and treatment of people with progressive chronic kidney disease (ASSIST-CKD): protocol for the stepped wedge implementation and evaluation of an intervention to reduce late presentation for renal replacement therapy

    Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community...

    Hugh Gallagher, Shona Methven, Anna Casula, Nicola Thomas, Charles R. V. Tomson, Fergus J. Caskey, Tracey Rose, Stephen J. Walters, David Kennedy, Anne Dawnay, Martin Cassidy, Richard Fluck, Hugh C. Rayner and Michael Nation

    BMC Nephrology 2017 18:131

    Published on: 11 April 2017

  9. Research article

    Citrate shows protective effects on cardiovascular and renal function in ischemia-induced acute kidney injury

    Ischemia and reperfusion (I/R) is one of the major causes of acute kidney injury (AKI). Citrate reduces hypoxia-induced mitochondrial energetic deficits in isolated proximal tubules. Moreover, citrate anticoag...

    Anja Bienholz, Jonas Reis, Pinar Sanli, Herbert de Groot, Frank Petrat, Hana Guberina, Benjamin Wilde, Oliver Witzke, Fuat H. Saner, Andreas Kribben, Joel M. Weinberg and Thorsten Feldkamp

    BMC Nephrology 2017 18:130

    Published on: 10 April 2017

  10. Research article

    Lower serum magnesium is associated with vascular calcification in peritoneal dialysis patients: a cross sectional study

    Coronary artery calcification (CAC) is highly prevalent among dialysis patients and is associated with increased cardiovascular and all cause mortality. Magnesium (Mg) inhibits vascular calcification in animal...

    Amber O. Molnar, Mohan Biyani, Ian Hammond, John Paul Harmon, Susan Lavoie, Brendan McCormick, Manish M. Sood, Jessica Wagner, Elena Pena and Deborah L. Zimmerman

    BMC Nephrology 2017 18:129

    Published on: 6 April 2017

  11. Research article

    Dementia is a risk factor for major adverse cardiac and cerebrovascular events in elderly Korean patients initiating hemodialysis: a Korean national population-based study

    Dementia is common in end-stage renal disease (ESRD) patients on hemodialysis (HD) and is associated with worse outcomes. This study aimed to investigate the risk of major adverse cardiac and cerebrovascular e...

    Sung Min Jung, Clara Tammy Kim, Ea Wha Kang, Kyoung Hoon Kim, Shina Lee, Hyung Jung Oh, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Dong-Ryeol Ryu and Hyunwook Kim

    BMC Nephrology 2017 18:128

    Published on: 6 April 2017

  12. Case report

    Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report

    Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a form of renal involvement by monoclonal IgG deposits that was found in mesangial, subendothelial or subepithelial regions. The distri...

    Rio Noto, Nozomu Kamiura, Yuichiro Ono, Sumie Tabata, Shigeo Hara, Hideki Yokoi, Akihiro Yoshimoto and Motoko Yanagita

    BMC Nephrology 2017 18:127

    Published on: 6 April 2017

  13. Study protocol

    Cost-effectiveness of home telemonitoring in chronic kidney disease patients at different stages by a pragmatic randomized controlled trial (eNephro): rationale and study design

    Home telemonitoring has developed considerably over recent years in chronic diseases in order to improve communication between healthcare professionals and patients and to promote early detection of deteriorat...

    Nathalie Thilly, Jacques Chanliau, Luc Frimat, Christian Combe, Pierre Merville, Philippe Chauveau, Pierre Bataille, Raymond Azar, David Laplaud, Christian Noël and Michèle Kessler

    BMC Nephrology 2017 18:126

    Published on: 5 April 2017

  14. Research article

    Sleep apnea prevalence in chronic kidney disease - association with total body water and symptoms

    Sleep apnea is common and associated with poor outcome in severe chronic kidney disease, but validated screening tools are not available. Our objectives were to determine the prevalence of sleep apnea in this ...

    Hsin-Chia Huang, Giles Walters, Girish Talaulikar, Derek Figurski, Annette Carroll, Mark Hurwitz, Krishna Karpe and Richard Singer

    BMC Nephrology 2017 18:125

    Published on: 4 April 2017

  15. Research article

    Prevalence of chronic kidney disease associated with cardiac and vascular complications in hypertensive patients: a multicenter, nation-wide study in Thailand

    Hypertension and chronic kidney disease (CKD) are common conditions and both are major risk factors for cardiovascular events. The objectives were 1) to study the prevalence of CKD in hypertensive patients and...

    Rungroj Krittayaphong, Ram Rangsin, Bandit Thinkhamrop, Cameron Hurst, Suthee Rattanamongkolgul, Nintita Sripaiboonkij and Wipaporn Wangworatrakul

    BMC Nephrology 2017 18:115

    Published on: 3 April 2017

  16. Research article

    Long-term clinical outcome for patients poisoned by the fungal nephrotoxin orellanine

    Accidental intake of mushrooms of the Cortinarius species (deadly webcap) may cause irreversible renal damage and the need for dialysis or transplantation. The species is found in forests of Northern Europe, Scan...

    Heidi Hedman, Johan Holmdahl, Johan Mölne, Kerstin Ebefors, Börje Haraldsson and Jenny Nyström

    BMC Nephrology 2017 18:121

    Published on: 3 April 2017

  17. Research article

    Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury

    Paraquat ingestion is frequently fatal. While biomarkers of kidney damage increase during paraquat-induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for diag...

    Fahim Mohamed, Nicholas A. Buckley, John W. Pickering, Klintean Wunnapuk, Sandamali Dissanayake, Umesh Chathuranga, Indika Gawarammana, Shaluka Jayamanne and Zoltan H. Endre

    BMC Nephrology 2017 18:122

    Published on: 3 April 2017

  18. Study protocol

    The Ferumoxytol for Anemia of CKD Trial (FACT)—a randomized controlled trial of repeated doses of ferumoxytol or iron sucrose in patients on hemodialysis: background and rationale

    Iron deficiency anemia (IDA) is a common manifestation of chronic kidney disease (CKD), affecting most patients on hemodialysis and imposing a substantial clinical burden. Treatment with iron supplementation i...

    Iain C. Macdougall, Naomi V. Dahl, Kristine Bernard, Zhu Li, Alka Batyky and William E. Strauss

    BMC Nephrology 2017 18:117

    Published on: 3 April 2017

  19. Research article

    Coping with kidney disease – qualitative findings from the Empowering Patients on Choices for Renal Replacement Therapy (EPOCH-RRT) study

    The highly burdensome effects of kidney failure and its management impose many life-altering changes on patients. Better understanding of successful coping strategies will inform patients and help health care ...

    Lalita Subramanian, Martha Quinn, Junhui Zhao, Laurie Lachance, Jarcy Zee and Francesca Tentori

    BMC Nephrology 2017 18:119

    Published on: 3 April 2017

  20. Review

    The 6R’s of drug induced nephrotoxicity

    Drug induced kidney injury is a frequent adverse event which contributes to morbidity and increased healthcare utilization. Our current knowledge of drug induced kidney disease is limited due to varying defini...

    Linda Awdishu and Ravindra L. Mehta

    BMC Nephrology 2017 18:124

    Published on: 3 April 2017

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