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Table 2 Adverse Events and Unadjusted Hazards for Cardiac, Stroke, Mortality and Composite Events Based on Kidney Function Classification

From: CKD classification based on estimated GFR over three years and subsequent cardiac and mortality outcomes: a cohort study

  

eGFR≥60

eGFR Increase

eGFR Decline

eGFR < 60

Cardiac

events/at risk; %

1,088/15,767; 6.9%

36/276; 13.0%

143/961; 14.9%

175/884; 19.8%

 

HR (CI)

Reference

2.10 (1.50, 2.92)

2.48 (2.08, 2.95)

3.66 (3.12, 4.30)

Stroke

events/at risk; %

568/15,870; 3.6%

23/277; 8.3%

81/970; 8.4%

114/887; 12.9%

 

HR (CI)

Reference

2.60 (1.71, 3.94)

2.73 (2.16, 3.44)

4.68 (3.82, 5.72)

Mortality

events/at risk; %

1,612/15,925; 10.1%

53/278; 19.1%

269/972; 27.7%

367/891; 41.2%

 

HR (CI)

Reference

2.10 (1.60, 2.76)

3.16 (2.78, 3.60)

5.27 (4.70, 5.90)

Composite

events/at risk; %

2,584/15,925; 16.2%

72/278; 25.9%

356/972; 36.6%

451/891; 50.6%

 

HR (CI)

Reference

1.81 (1.43, 2.28)

2.68 (2.40, 2.99)

4.17 (3.77, 4.61)

  1. HR, Hazard Ratio; CI, 95% confidence interval
  2. Lower 'at risk' numbers for cardiac and stroke outcomes reflect 178 and 62 individuals, respectively, who had a cardiac event and a stroke between visits 1 and 2.
  3. Difference between eGFR increase and decline non-significant for cardiac (p = 0.37) and stroke outcomes (p = 0.84) and significant for mortality (p = 0.006) and composite outcomes (0.002).