Articles

Parathyroid carcinoma arising from auto-transplanted parathyroid tissue after Total Parathyroidectomy in chronic kidney disease patient: a case report

Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease that requires vigilant treatment due to its high mortality rate. Pharmacologic therapy is recommended as an initia...

Authors: Ho-Ryun Won, Jae Yoon Kang, In Ho Lee, Jin-Man Kim, Jae Won Chang and Bon Seok Koo

Desmopressin and bleeding risk after percutaneous kidney biopsy

Desmopressin is used to reduce bleeding after kidney biopsy but evidence supporting its use is weak, especially in patients with elevated creatinine. The present study was undertaken to evaluate efficacy of de...

Authors: Ambarish Athavale, Hemant Kulkarni, Cagil D. Arslan and Peter Hart

Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging

Inflammaging is a persistent, low−grade, sterile, nonresolving inflammatory state, associated with the senescence of the immune system. Such condition downregulates both innate and adaptive immune responses du...

Authors: Vincenzo Sepe, Marilena Gregorini, Teresa Rampino, Pasquale Esposito, Rosanna Coppo, Francesco Galli and Carmelo Libetta

Delayed administration of suramin attenuates peritoneal fibrosis in rats

Peritoneal fibrosis is the most common complication of peritoneal dialysis, but there is currently no effective treatment. We previously reported that suramin pretreatment prevents the development of peritonea...

Authors: Chongxiang Xiong, Na Liu, Xiaofei Shao, Sairah Sharif, Hequn Zou and Shougang Zhuang

Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli

IgA nephropathy (IgAN) involves mesangial matrix expansion, but the proteomic composition of this matrix is unknown. The present study aimed to characterize changes in extracellular matrix in IgAN.

Authors: Flavia Teodora Ioana Paunas, Kenneth Finne, Sabine Leh, Tarig Al-Hadi Osman, Hans-Peter Marti, Frode Berven and Bjørn Egil Vikse

Prediction of kidney transplant outcome based on different DGF definitions in Chinese deceased donation

Delayed graft function (DGF) is an important complication of kidney transplantation and can be diagnosed according to different definitions. DGF has been suggested to be associated with the long-term outcome o...

Authors: Xiao-jun Hu, Jin Zheng, Yang Li, Xiao-hui Tian, Pu-xun Tian, He-li Xiang, Xiao-ming Pan, Chen-guang Ding, Xiao-ming Ding and Wu-jun Xue

Patient-centered Pharmacist Care in the Hemodialysis Unit: a quasi-experimental interrupted time series study

Nonadherence to medications by patients requiring hemodialysis (HD) leads to unfavorable clinical outcomes. Limited data exist to demonstrate the effect of incorporating patient-centered interventions using co...

Authors: Sherine Ismail, Abrar Al-Subhi, Eman Youssif, Medhat Ahmed, Abdullah Almalki, Diane L. Seger, Andrew C. Seger and Earl Cook

Optimizing renal replacement therapy for patients who need extracorporeal membrane oxygenation: cross-talk between two organ support machines

Following a substantial increase in the utilization of extracorporeal membrane oxygenation (ECMO) during the last decade, its associated benefits and complications, including acute kidney injury have become mo...

Authors: Kianoush Kashani and Marlies Ostermann

Superagonistic CD28 protects against renal ischemia injury induced fibrosis through a regulatory T-cell expansion dependent mechanism

Authors: Yiran Liang, Ning Xue, Xiaoyan Wang, Xiaoqiang Ding and Yi Fang

Pattern of renal amyloidosis in South Africa

Kidney disease is a serious manifestation of systemic amyloidosis and a major cause of morbidity and mortality. Tuberculosis (TB) occurs up to 27 times more commonly in human immunodeficiency virus (HIV) infec...

Authors: Muhammed Hassen, William Bates and Mohammed Rafique Moosa

Simultaneous intrathyroidal parathyroid adenomas and multifocal papillary thyroid carcinoma in a patient with kidney transplantation: a case report

Persistent hyperparathyroidism after kidney transplantation has been associated with adverse outcomes. Parathyroidectomy is the definitive treatment approach, but the success of parathyroidectomy relies on the...

Authors: Jun Yang, Jun Zhang, Jian-li Bi, Wan-wen Weng and Meng-jie Dong

Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study

The renal function of the remaining kidney in living donors recovers up to 60~70% of pre-donation estimated-glomerular filtration rate (eGFR) by compensatory hypertrophy. However, the degree of this hypertroph...

Authors: Sho Nishida, Yuji Hidaka, Mariko Toyoda, Kohei Kinoshita, Kosuke Tanaka, Chiaki Kawabata, Satoshi Hamanoue, Akito Inadome, Hiroshi Yokomizo, Asami Takeda, Soichi Uekihara and Shigeyoshi Yamanaga

Non-adherence to Haemodialysis, Interdialytic weight gain and cardiovascular mortality: a cohort study

Patients with chronic kidney diseases (CKD) on haemodialysis (HD) have high morbidity and mortality rates, which are also due to the inherent risks associated with nephropathy. Non-adherence (NA) to the differ...

Authors: Lianna G. G. Dantas, Mário de Seixas Rocha, José Andrade Moura Junior, Edson Luiz Paschoalin, Sandra R. K. P. Paschoalin and Constança M. Sampaio Cruz

Clinical practice guideline on pregnancy and renal disease

Authors: Kate Wiles, Lucy Chappell, Katherine Clark, Louise Elman, Matt Hall, Liz Lightstone, Germin Mohamed, Durba Mukherjee, Catherine Nelson-Piercy, Philip Webster, Rebecca Whybrow and Kate Bramham

CTNS mRNA molecular analysis revealed a novel mutation in a child with infantile nephropathic cystinosis: a case report

Cystinosis is an autosomal recessive lysosomal storage disorder characterized by accumulation of cystine in lysosomes throughout the body. Cystinosis is caused by mutations in the CTNS gene that encodes the lysos...

Authors: Svetlana Papizh, Victoria Serzhanova, Alexandra Filatova, Mikhail Skoblov, Vyacheslav Tabakov, Lambert van den Heuvel, Elena Levtchenko and Larisa Prikhodina

Atherosclerotic vascular disease is more prevalent among black ESKD patients on long-term CAPD in South Africa

Occurrence of cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) can be described as a “cruel alliance”, with CVD responsible for about half of all deaths among CKD patients. Chronic k...

Authors: S. O. Oguntola, M. O. Hassan, R. Duarte, A. Vachiat, P. Manga and S. Naicker

Exercise therapy improves eGFR, and reduces blood pressure and BMI in non-dialysis CKD patients: evidence from a meta-analysis

Patients with chronic kidney disease (CKD) have a high prevalence of cardiovascular diseases, which often lead to physical inactivity that correlates with CKD exacerbation. The benefits of regular exercise to ...

Authors: Lijun Zhang, Yangyang Wang, Lianlian Xiong, Yanfang Luo, Zhijun Huang and Bin Yi

Glycemia affects glomerular filtration rate in people with type 2 diabetes

In type 2 diabetes (T2DM), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) systematically underestimates the measured adjusted glomerula...

Authors: E. Jennifer Weil, Sayuko Kobes, Lois I. Jones and Robert L. Hanson

Changes in serum albumin and other nutritional markers when using sucroferric oxyhydroxide as phosphate binder among hemodialysis patients: a historical cohort study

Elevated serum phosphorus concentrations are common among maintenance hemodialysis patients. Protein is a major source of dietary phosphate, but restriction of protein intake can result in hypoalbuminemia and ...

Authors: Kamyar Kalantar-Zadeh, Linda H. Ficociello, Vidhya Parameswaran, Nicolaos V. Athienites, Claudy Mullon, Robert J. Kossmann and Daniel W. Coyne

Association of platelet function with depression and its treatment with sertraline in patients with chronic kidney disease: analysis of a randomized trial

Major Depressive Disorder (MDD) can lead to adverse cardiovascular outcomes in patients with chronic kidney disease (CKD). Although one of the proposed mechanisms is heightened platelet activation, effects of ...

Authors: Nishank Jain, Fei Wan, Monica Kothari, Anuoluwapo Adelodun, Jerry Ware, Ravi Sarode and S. Susan Hedayati

Muir–Torre syndrome: sebaceous carcinoma concurrent with colon cancer in a kidney transplant recipient; a case report

Sebaceous carcinoma is a rare but progressive malignant skin cancer, and the incidence is approximately five times higher in post-transplant patients than in people who have not received kidney transplants. Se...

Authors: Masahiro Tomonari, Mariko Shimada, Yasuyuki Nakada, Izumi Yamamoto, Munenari Itoh, Yusuke Koike, Akimitsu Kobayashi, Jun Miki, Hiroki Yamada, Takahiro Kimura, Shinya Saito, Kokichi Sugano, Shigeki Sekine, Hiroyasu Yamamoto, Akihiko Asahina and Takashi Yokoo

Salivary creatinine as a diagnostic tool for evaluating patients with chronic kidney disease

Preliminary studies have shown the potential use of salivary creatinine concentration in the diagnosis of chronic kidney disease (CKD). For saliva to replace serum as a diagnostic tool, studies must be done to...

Authors: Dada Oluwaseyi Temilola, Karla Bezuidenhout, Rajiv Timothy Erasmus, Lawrence Stephen, Mogamat Razeen Davids and Haly Holmes

Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review

Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathoph...

Authors: Eduardo De la Cruz-Cano, Cristina del C. Jiménez-González, Vicente Morales-García, Conny Pineda-Pérez, Juan G. Tejas-Juárez, Francisco J. Rendón-Gandarilla, Silvia Jiménez-Morales and José A. Díaz-Gandarilla

Albumin losses during hemodiafiltration: all dialyzers are not created equal - a case report

Online hemodiafiltration (OL-HDF) is associated with better removal of both small and middle molecules and might improve survival compared to conventional hemodialysis (HD). Nevertheless, hemodiafiltration (HD...

Authors: Charles Cuvelier, Michel Tintillier, Gabriela Migali, Charlotte Van Ende and Jean-Michel Pochet

Urinary cell-free mitochondrial and nuclear deoxyribonucleic acid correlates with the prognosis of chronic kidney diseases

Cell-free deoxyribonucleic acid DNA (cf-DNA) in urine is promising due to the advantage of urine as an easily obtained and non-invasive sample source over tissue and blood. In clinical practice, it is importan...

Authors: Chia-Chu Chang, Ping-Fang Chiu, Chia-Lin Wu, Cheng-Ling Kuo, Ching-Shan Huang, Chin-San Liu and Ching-Hui Huang

Death due to delirium: a case of a self-cut hemodialysis dialysis catheter - a case report

Neuropsychiatric conditions such as depression, delirium and cognitive impairment are common in patients with end-stage kidney disease (ESKD) and individuals suffering from ESKD are more likely to commit suici...

Authors: Pierre Antoine Brown, Peter O. Magner, Swapnil Hiremath and Edward G. Clark

Clinical practice guideline management of blood borne viruses within the haemodialysis unit

Some people who are receiving dialysis treatment have virus infection such as hepatitis B, hepatitis C and/or HIV that is present in their blood. These infections can be transmitted to other patients if blood ...

Authors: Elizabeth Garthwaite, Veena Reddy, Sam Douthwaite, Simon Lines, Kay Tyerman and James Eccles

Liddle syndrome due to a novel mutation in the γ subunit of the epithelial sodium channel (ENaC) in family from Russia: a case report

Liddle syndrome is a monogenic disease with autosomal dominant inheritance. Basic characteristics of this disease are hypertension, reduced concentration of aldosterone and renin activity, as well as increased...

Authors: Anastasiya A. Kozina, Tatiana A. Trofimova, Elena G. Okuneva, Natalia V. Baryshnikova, Varvara A. Obuhova, Anna Yu. Krasnenko, Kirill Yu. Tsukanov, Olesya I. Klimchuk, Ekaterina I. Surkova, Peter A. Shatalov and Valery V. Ilinsky

Left ventricular hypertrophy in a contemporary cohort of autosomal dominant polycystic kidney disease patients

Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) often develop hypertension in childhood or early adulthood. Although this could result in left ventricular hypertrophy (LVH), a major risk fac...

Authors: Huanwen Chen, Terry Watnick, Susie N. Hong, Barry Daly, Yongfang Li and Stephen L. Seliger

Nephrologists’ emotional burden regarding decision-making about dialysis initiation in older adults: a qualitative study

Conservative management, an approach to treating end-stage kidney disease without dialysis, while generally associated with shorter life expectancy than treatment with dialysis, is associated with fewer hospit...

Authors: Melissa W. Wachterman, Tarikwa Leveille, Nancy L. Keating, Steven R. Simon, Sushrut S. Waikar and Barbara Bokhour

Efficacy and safety of cyclosporine a for patients with steroid-resistant nephrotic syndrome: a meta-analysis

The purpose of this study was to determine efficacy and safety of cyclosporine A (CsA) for patients with steroid-resistant nephrotic syndrome (SRNS).

Authors: Hong-Yan Li, Xialan Zhang, Tianbiao Zhou, Zhiqing Zhong and Hongzhen Zhong

Analysis of misdiagnosed cases of hemorrhagic fever with renal syndrome in children: two cases and literature review

Hemorrhagic fever with renal syndrome (HFRS) is an acute disease caused by hantavirus infection and is clinically characterized by fever, various hemorrhagic manifestations and transient renal and hepatic dysf...

Authors: Li Zhang, Qing-shan Ma, Yan Zhang, Bai-chao Sun and Leng-yue Zhao

The association of dialysis adequacy, body mass index, and mortality among hemodialysis patients

Although hemodialysis (HD) adequacy, single-pool Kt/V_urea (spKt/V), is inversely correlated with body size, each is known to affect patient survival in the same direction. Therefore, we sought to examine the rela...

Authors: Woong-pyo Hong and Yu-Ji Lee

Pathologic tonsillar findings similar to IgA nephropathy and the role of tonsillectomy in a patient with nephrotic syndrome

Background: The pathological findings of tonsils in IgA nephropathy include the expansion of T-cell nodules around lymphoid follicles and abnormal reticulation of the crypt epithelium in contrast to chronic to...

Authors: Takuji Enya, Tomoki Miyazawa, Kohei Miyazaki, Rina Oshima, Yuichi Morimoto, Mitsuru Okada, Tsukasa Takemura and Keisuke Sugimoto

Cancer patterns and association with mortality and renal outcomes in non-dialysis dependent chronic kidney disease: a matched cohort study

Cancer in patients with chronic kidney disease (CKD) is an added burden to their overall morbidity and mortality. Cancer can be a cause or an effect of CKD. In CKD patients, a better understanding of cancer di...

Authors: Rajkumar Chinnadurai, Emma Flanagan, Gordon C. Jayson and Philip A. Kalra

Renal Association Clinical Practice Guideline on Haemodialysis

This guideline is written primarily for doctors and nurses working in dialysis units and related areas of medicine in the UK, and is an update of a previous version written in 2009. It aims to provide guidance...

Authors: Damien Ashby, Natalie Borman, James Burton, Richard Corbett, Andrew Davenport, Ken Farrington, Katey Flowers, James Fotheringham, R. N. Andrea Fox, Gail Franklin, Claire Gardiner, R. N. Martin Gerrish, Sharlene Greenwood, Daljit Hothi, Abdul Khares, Pelagia Koufaki…

Developing nephrology services in low income countries: a case of Tanzania

The burden of kidney diseases is reported to be higher in lower- and middle-income countries as compared to developed countries, and countries in sub-Saharan Africa are reported to be most affected. Health sys...

Authors: Francis F. Furia, Jacqueline Shoo, Paschal J. Ruggajo, Kajiru Kilonzo, Gopal Basu, Karen Yeates, Santosh Varughese, Einar Svarstad and Onesmo Kisanga

Renal injury following long-term exposure to carbon disulfide: analysis of a case series

To investigate the clinicopathological characteristics of renal damage caused by long-term exposure to carbon disulfide (CS2) in nine patients.

Authors: Yongqin Yan, Cheng Wang, Zhiyong Zheng, Lijuan Qu, Dehua Zeng and Min Li

A case report on lipofuscin deposition in a graft biopsy two years after kidney transplantation: an insignificant bystander or a pathogenic benefactor?

Lipofuscin deposition is a characteristic manifestation of aging. There is very limited literature in humans and in animals describing these deposits in native kidneys. Overall, it is thought to be non-pathoge...

Authors: Vivian W. Y. Leung, Sarah-Jeanne Pilon, Pierre O. Fiset and Shaifali Sandal

TAFRO syndrome as a cause of glomerular microangiopathy: a case report and literature review

TAFRO syndrome is a systemic inflammatory disorder that manifests as thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Renal dysfunction is frequently complicated wit...

Authors: Yoshikuni Nagayama, Mizuki Yamano, Motoka Yagame, Tomoyuki Nariyama, Mikiko Takahashi, Masashi Kawamoto and Katsuyuki Matsui

Treatment of lead and arsenic poisoning in anuric patients – a case report and narrative review of the literature

Heavy metal poisoning can cause debilitating illness if left untreated, and its management in anuric patients poses challenges. Literature with which to guide clinical practice in this area is rather scattered.

Authors: Chun-Yuan Hsiao, Chip Gresham and Mark R. Marshall

Association of medication non-adherence with short-term allograft loss after the treatment of severe acute kidney transplant rejection

Medication non-adherence is a risk factor for acute kidney transplant rejection. The association of non-adherence with short-term allograft loss in patients who develop acute rejection and are subsequently tre...

Authors: Ahmed Al-Sheyyab, Laura Binari, Mohammed Shwetar, Everly Ramos, Meghan E. Kapp, Stefanie Bala, Nikita Wilson, Rachel C. Forbes, J. Harold Helderman, Khaled Abdel-Kader and Beatrice P. Concepcion

A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat, administered three times weekly in patients with anemia on hemodialysis

Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD) in both dialysis and nondialysis patients. In clini...

Authors: Christine K. Bailey, Stephen Caltabiano, Alexander R. Cobitz, Chun Huang, Kelly M. Mahar and Vickas V. Patel

Comparison between three different equations for the estimation of glomerular filtration rate in predicting mortality after coronary artery bypass

This study was undertaken to compare the accuracy of chronic kidney disease-epidemiology collaboration (eGFR_CKD-EPI) to modification of diet in renal disease (eGFR_MDRD) and the Cockcroft-Gault formulas of Creatin...

Authors: Sandro Gelsomino, Massimo Bonacchi, Fabiana Lucà, Fabio Barili, Stefano Del Pace, Orlando Parise, Daniel M. Johnson and Michele Massimo Gulizia

Clinical practice guideline on undernutrition in chronic kidney disease

Authors: Mark Wright, Elizabeth Southcott, Helen MacLaughlin and Stuart Wineberg

Association between mineral and bone disorder in patients with acute kidney injury following cardiac surgery and adverse outcomes

Numerous studies have evaluated the prevalence and importance of mineral and bone disorders among patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, little is known about d...

Authors: Tianye Yang, Wenji Wang, Xiao Tang, Peng Shi, Lulu Zhang, Wenyan Yu, Yingxin Xie, Daqiao Guo and Feng Ding

Complete post-operative resolution of “temporary” end-stage kidney disease secondary to aortic dissection without static renal artery obstruction: a case study

Acute kidney injury (AKI), which may progress to end-stage kidney disease (ESKD), is a potential complication of aortic dissection. Notably, in all reported ESKD cases secondary to aortic dissection, imaging e...

Authors: Yoshihiro Mukaiyama, Akira Okada, Yutaro Kawakatsu, Satoshi Akuzawa, Kazuchika Suzuki, Naoyuki Ishigami and Tatsuo Yamamoto

Early detection of acute kidney injury in the perioperative period of liver transplant with neutrophil gelatinase-associated lipocalin

Acute kidney injury (AKI) is a common complication in patients undergoing liver transplant (LT) and is associated with high morbidity and mortality. We aim to evaluate the pattern of urine and plasma neutrophi...

Authors: Camila Lima, Luciana Bertocco de Paiva Haddad, Patrícia Donado Vaz de Melo, Luiz Marcelo Malbouisson, Lilian Pires Freitas do Carmo, Luiz Augusto Carneiro D’Albuquerque and Etienne Macedo

Ipilimumab-induced renal granulomatous arteritis: a case report

Immune Checkpoint Inhibitors (ICPIs) are promising new drugs in treatment of advanced tumours targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD1) or its ligand (PDL-1)...

Authors: Mathilde Lemoine, Baptiste Dilly, Alexandre Curie, Vivien Hébert, Charlotte Laurent, Mélanie Hanoy, Steven Grangé, Dominique Guerrot, Arnaud François and Dominique Bertrand

The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research

Kidney transplantation is considered to be the treatment of choice for people with end-stage renal disease (ESRD). However, due to the shortage of available organs and the increase in the ESRD prevalence in Eu...

Authors: M. Lorent, Y. Foucher, K. Kerleau, S. Brouard, C. Baayen, S. Lebouter, M. Naesens, O. Bestard Matamoros, A. Åsberg and M. Giral