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  1. The causes of anaemia in patients with end-stage renal disease include a relative deficiency in erythropoietin production and complex clinical conditions. We aimed to investigate the underlying mechanisms of a...

    Authors: Koichiro Matsumura, Toshika Okumiya, Tetsuro Sugiura, Nobuyuki Takahashi, Yoshihiro Yamamoto, Sanae Kikuchi, Kenichi Fujii, Munemitsu Otagaki and Ichiro Shiojima

    Citation: BMC Nephrology 2020 21:418

    Content type: Research article

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  2. Acute kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. However, approaches to estimate baseline creatinine (bSCr) are not standardized in...

    Authors: Anthony Batte, Michelle C. Starr, Andrew L. Schwaderer, Robert O. Opoka, Ruth Namazzi, Erika S. Phelps Nishiguchi, John M. Ssenkusu, Chandy C. John and Andrea L. Conroy

    Citation: BMC Nephrology 2020 21:417

    Content type: Research article

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  3. Minimal change disease (MCD) is one of the causes of idiopathic nephrotic syndrome in adults. The pathogenesis of proteinuria in MCD has not been fully understood. Recently, it has been reported that the recep...

    Authors: Keisuke Horikoshi, Norihiko Sakai, Naoki Yamamoto, Hisayuki Ogura, Koichi Sato, Taro Miyagawa, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Miho Shimizu, Kengo Furuichi and Takashi Wada

    Citation: BMC Nephrology 2020 21:416

    Content type: Case report

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  4. Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and it is associated with poor clinical outcomes and quality of life. It is not clear if growth differentiation factor-15...

    Authors: Aishatu M. Nalado, Gbenga Olorunfemi, Therese Dix-Peek, Caroline Dickens, Lungile Khambule, Tracy Snyman, Graham Paget, Johnny Mahlangu, Raquel Duarte, Jaya George and Saraladevi Naicker

    Citation: BMC Nephrology 2020 21:415

    Content type: Research article

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  5. Chronic kidney disease (CKD) patients, especially those with end stage renal disease (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investiga...

    Authors: Xiaobo Duan, Xiaolei Chen, Megha Gupta, Dutmanee Seriwatanachai, Hanxiao Xue, Qiuchan Xiong, Tong Xu, Dan Li, Anchun Mo, Xi Tang, Xuedong Zhou, Yuqing Li and Quan Yuan

    Citation: BMC Nephrology 2020 21:414

    Content type: Research article

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  6. Cardiovascular disease is the most common cause of death in patients with end-stage kidney disease on haemodialysis. The potential clinical consequence of systematic echocardiographic assessment is however not...

    Authors: Anna Axelsson Raja, Peder E. Warming, Ture L. Nielsen, Louis L. Plesner, Mads Ersbøll, Morten Dalsgaard, Morten Schou, Casper Rydahl, Lisbet Brandi and Kasper Iversen

    Citation: BMC Nephrology 2020 21:413

    Content type: Research article

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  7. Acute kidney injury (AKI) is defined as a sudden event of kidney failure or kidney damage within a short period. Ischemia-reperfusion injury (IRI) is a critical factor associated with severe AKI and end-stage ...

    Authors: Meeyoung Park, Chae Hwa Kwon, Hong Koo Ha, Miyeun Han and Sang Heon Song

    Citation: BMC Nephrology 2020 21(Suppl 1):398

    Content type: Research

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    This article is part of a Supplement: Volume 21 Supplement 1

  8. The optimal choice of treatment, with hemodialysis (HD) or peritoneal dialysis (PD), for end-stage renal disease (ESRD) patients, is still controversial. Only a few studies comparing HD and PD have been conduc...

    Authors: Zhiren He, Haijing Hou, Difei Zhang, Yenan Mo, La Zhang, Guobin Su, Junjie Lin, Liming Lu, Jingyao Huang, Yewen Gu, Ying Zhang, Jingxia Lin, Fengling Yuan, Yu Peng, Hui Liang, Daixin Zhao…

    Citation: BMC Nephrology 2020 21:412

    Content type: Research article

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  9. Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in ...

    Authors: A. C. Nixon, T. J. Wilkinson, H.M.L. Young, M. W. Taal, N. Pendleton, S. Mitra, M. E. Brady, A. P. Dhaygude and A. C. Smith

    Citation: BMC Nephrology 2020 21:411

    Content type: Research article

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  10. Concurrent type 1 diabetes mellitus (T1DM) and idiopathic nephrotic syndrome is rare, and most previously reported cases were in children. We report the case of an adult woman who developed T1DM and minimal ch...

    Authors: Ryuzoh Nishizono, Hiroki Kogou, Yuri Ishizaki, Akihiro Minakawa, Masao Kikuchi, Hiroko Inagaki, Yuji Sato and Shouichi Fujimoto

    Citation: BMC Nephrology 2020 21:410

    Content type: Case report

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  11. This scoping review sought to summarize available data on the prevalence, associated factors, etiology, comorbidities, treatment, cost and mortality of chronic kidney disease (CKD) in Cameroon.

    Authors: Jerry Brown Aseneh, Ben-Lawrence A. Kemah, Stephane Mabouna, Mbeng Emmanuel Njang, Domin Sone Majunda Ekane and Valirie Ndip Agbor

    Citation: BMC Nephrology 2020 21:409

    Content type: Review

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  12. Autosomal dominant polycystic kidney disease (ADPKD), the predominant type of inherited kidney disorder, occurs due to PKD1 and PKD2 gene mutations. ADPKD diagnosis is made primarily by kidney imaging. However, m...

    Authors: Fatemeh Khadangi, Adam Torkamanzehi and Mohammad Amin Kerachian

    Citation: BMC Nephrology 2020 21:408

    Content type: Research article

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  13. The epidemiology of dialysis patients has been little studied in developing countries and economies in transition. We examined the prevalence, incidence and mortality rate of dialysis patients in Kazakhstan, v...

    Authors: Abduzhappar Gaipov, Alpamys Issanov, Kainar Kadyrzhanuly, Dinara Galiyeva, Marina Khvan, Mohamad Aljofan, Miklos Z. Molnar and Csaba P. Kovesdy

    Citation: BMC Nephrology 2020 21:407

    Content type: Research article

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  14. Herein, a 3-year-old boy presented with hidden-onset isolated proteinuria was reported. The disease was induced by COQ8B (previously termed ADCK4) compound heterozygous variants, including c.[271C > T] and c.[737...

    Authors: Shu-bo Zhai, Li Zhang, Bai-chao Sun, Yan Zhang and Qing-shan Ma

    Citation: BMC Nephrology 2020 21:406

    Content type: Case report

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  15. We here report on the first observation of a C3 mutation that is related to atypical hemolytic and uremic syndrome (aHUS), which occurred in a pancreatic islet transplant patient. Immunosuppressive treatments,...

    Authors: Thibault Bahougne, Jérome Olagne, Marion Munch, Laura Braun-Parvez, Marie-Pierrette Chenard, Véronique Frémeaux-Bacchi, Sophie Caillard, Philippe Baltzinger, Michel Greget, Laurence Kessler and Bruno Moulin

    Citation: BMC Nephrology 2020 21:405

    Content type: Case report

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  16. Peritoneal dialysis (PD)-related peritonitis is a rare but serious complication and is associated with increased morbidity and mortality rates. It is most commonly caused by Staphylococcus aureus or Staphylococcu...

    Authors: Kristina Boss, Ina Wiegard-Szramek, Jan Dziobaka, Andreas Kribben and Sebastian Dolff

    Citation: BMC Nephrology 2020 21:404

    Content type: Case report

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  17. Calciphylaxis is a rare condition usually seen in patients with end-stage renal disease. Pain is a hallmark of this condition and can be extremely difficult to control. Anecdotal data suggests that pain manage...

    Authors: Rajkumar Chinnadurai, Smeeta Sinha, Aoife C Lowney and Mary Miller

    Citation: BMC Nephrology 2020 21:403

    Content type: Research article

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  18. Dipeptidyl peptidase-4 (DPP-4) is a serine protease that inhibits the degradation of glucagon-like peptide 1. DPP-4 inhibitors are used worldwide to treat type 2 diabetes mellitus and were recently shown to ha...

    Authors: Ayano Kubo, Teruo Hidaka, Maiko Nakayama, Yu Sasaki, Miyuki Takagi, Hitoshi Suzuki and Yusuke Suzuki

    Citation: BMC Nephrology 2020 21:402

    Content type: Research article

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  19. Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2...

    Authors: Vivek Charu, Nicole Andeen, Vighnesh Walavalkar, Jessica Lapasia, Jin-Yon Kim, Andrew Lin, Richard Sibley, John Higgins, Megan Troxell and Neeraja Kambham

    Citation: BMC Nephrology 2020 21:401

    Content type: Research article

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  20. C3-glomerulonephritis can lead to progressive renal impairment from complement-mediated glomerular injury. Incidence and outcomes of C3-glomerulonephritis are not known in the New Zealand population.

    Authors: Luke J. Sutherland and Hari Talreja

    Citation: BMC Nephrology 2020 21:399

    Content type: Research article

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  21. Fungal peritonitis (FP) is an infrequent but serious complication in children undergoing peritoneal dialysis (PD). This study aimed to explore the risk factors, clinical manifestations, causative organisms, fu...

    Authors: Mohammed Alsuhaibani, Egab Aldosari, Khawla A. Rahim, Saeed Alzabli and Dayel Alshahrani

    Citation: BMC Nephrology 2020 21:400

    Content type: Research article

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  22. We aimed to examine the risk factors for chronic kidney disease (CKD) stage 3 among adults with ASK from unilateral nephrectomy.

    Authors: Wen-Jun Zhang, Zi-Yi Wang, Wei-Xing Zhou, Ning-Qiang Yang, Ya Wang, Ya Tang, Xiao-Chun Zhou, Jie-Cao Dao, Yan-Ru Ma, Yan-Ping He, Xiao-Ling Wang, Wen-Ge Wang and Li Yang

    Citation: BMC Nephrology 2020 21:397

    Content type: Research article

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  23. Minimal change disease (MCD) is one of the major causes of nephrotic syndrome (NS). A confirmed MCD diagnosis mainly depends on renal biopsy at present, which is an invasive procedure with many potential risks...

    Authors: Gaofei Yan, Guanzhi Liu, Xuefei Tian, Lifang Tian, Hao Wang, Peiyao Ren, Xiaotao Ma, Rongguo Fu and Zhao Chen

    Citation: BMC Nephrology 2020 21:396

    Content type: Technical advance

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  24. Cryoglobulinemic glomerulonephritis (CryoGn) caused by hepatitis B virus (HBV) infection was rarely reported. Our study aimed to investigate the clinical features, renal pathology findings, and prognosis in pa...

    Authors: Chao Li, Hang Li, Wei Su, Yu-bing Wen, Wei Ye, Wen-ling Ye, Jian-fang Cai, Xu-zhen Qin, Xue-mei Li and Xue-wang Li

    Citation: BMC Nephrology 2020 21:395

    Content type: Research article

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  25. Platelet activation is an important side effect of dialysis, resulted in a subsequent release of arachidonic acid (AA) from activated platelets. AA is involved in many pathologic conditions, such as inflammati...

    Authors: Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz and Barbara Dołęgowska

    Citation: BMC Nephrology 2020 21:394

    Content type: Research article

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  26. Hyponatremia is known to be associated with a worse patient outcome in heart failure. In cardiorenal syndrome (CRS), the prognostic role of concomitant hyponatremia is unclear. We sought to evaluate potential ...

    Authors: Rainer U. Pliquett, Katrin Schlump, Andreas Wienke, Babett Bartling, Michel Noutsias, Alexander Tamm and Matthias Girndt

    Citation: BMC Nephrology 2020 21:393

    Content type: Research article

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  28. Immune checkpoint inhibitors (ICI) have become the standard of care in many oncological conditions but are associated with a spectrum of renal immune-related adverse events (IrAEs). We aimed to describe the sp...

    Authors: Sebastian Hultin, Kazi Nahar, Alexander M. Menzies, Georgina V. Long, Suran L. Fernando, Victoria Atkinson, Jonathan Cebon and Muh Geot Wong

    Citation: BMC Nephrology 2020 21:391

    Content type: Research article

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  30. Serum neutrophil gelatinase-associated lipocalin (NGAL) could be used as a predictive marker of acute kidney injury (AKI) in patients with return of spontaneous circulation (ROSC) after out-of-hospital cardiac...

    Authors: Yoon Hee Choi, Dong Hoon Lee and Jae Hee Lee

    Citation: BMC Nephrology 2020 21:389

    Content type: Research article

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  31. New-onset diabetes after transplantation (NODAT) is associated with reduced patient and graft survival. This study examined the clinical and selected genetic factors associated with NODAT among renal-transplan...

    Authors: Rhanye Mac Guad, Andrew W. Taylor-Robinson, Yuan Seng Wu, Siew Hua Gan, Nur Lisa Zaharan, Roma Choudhury Basu, Constance Sat Lin Liew and Wan Ahmad Hafiz Wan Md Adnan

    Citation: BMC Nephrology 2020 21:388

    Content type: Research article

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  32. An epidemic of chronic kidney disease of unknown cause (CKDu) is occurring in rural communities in tropical regions of low-and middle-income countries in South America and India. Little information is availabl...

    Authors: Sophie A. Hamilton, Wisdom P. Nakanga, Josephine E. Prynn, Amelia C. Crampin, Daniela Fecht, Paolo Vineis, Ben Caplin, Neil Pearce and Moffat J. Nyirenda

    Citation: BMC Nephrology 2020 21:387

    Content type: Research article

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  33. The association between lower serum sodium levels and the clinical outcomes of insomnia patients remains unclear. We explored whether lower serum sodium is associated with poor clinical outcomes in patients wi...

    Authors: Eunjin Bae, Tae Won Lee, Ha Nee Jang, Hyun Seop Cho, Sehyun Jung, Seunghye Lee, Se-Ho Chang and Dong Jun Park

    Citation: BMC Nephrology 2020 21:386

    Content type: Research article

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  34. Excess cadmium (Cd) intake poses a general risk to health and to the kidneys in particular. Among indices of renal dysfunction under Cd burden measures are the urinary N-acetyl-β-D-glucosidase (UNAG) and urina...

    Authors: Yuting Li, Hongmei Wang, Jie Yu, Qiong Yan, Honggang Hu, Lishu Zhang, Tian Tian, Xianglei Peng, Shuo Yang and Shen Ke

    Citation: BMC Nephrology 2020 21:385

    Content type: Research article

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  35. This article describes the analysis and interpretation of data relating to the presence of cadmium, lead, mercury and fluoride in human bone samples obtained from cadavers of patients dying of Chronic Kidney D...

    Authors: Thalarabe Bulathge Ananda Jayalal, Sanath Thushara Chamakara Mahawithanage, Senanayaka Mudiyanselage Harshana Mahendra Kumara Senanayaka and Prasanna Bandara Dassanayaka

    Citation: BMC Nephrology 2020 21:384

    Content type: Research article

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  36. Kidney disease and dialysis significantly impact cognitive function across the age spectrum. Cognitive training (CT) and/or exercise training (ET) are promising approaches to preserve cognitive function among ...

    Authors: Mara A. McAdams-DeMarco, Nadia M. Chu, Malu Steckel, Sneha Kunwar, Marlís González Fernández, Michelle C. Carlson, Derek M. Fine, Lawrence J. Appel, Marie Diener-West and Dorry L. Segev

    Citation: BMC Nephrology 2020 21:383

    Content type: Study protocol

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  37. Previous studies have identified retinal microvascular features associated with renal dysfunction. Biopsies are necessary to confirm kidney microvascular damage and retinal imaging may enable evaluation of mic...

    Authors: R. A. O’Neill, A. P. Maxwell, F. Kee, I. Young, B. McGuinness, R. E. Hogg and McKay GJ

    Citation: BMC Nephrology 2020 21:382

    Content type: Research article

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  38. Acute kidney injury (AKI) often occurs in critically ill patients. AKI is associated with mortality and morbidity. Interventions focusing on the reduction of AKI are suggested by the Kidney Disease: Improving ...

    Authors: Jacqueline Koeze, Iwan C. C. van der Horst, Renske Wiersema, Frederik Keus, Willem Dieperink, Eline G. M. Cox, Jan G. Zijlstra and Matijs van Meurs

    Citation: BMC Nephrology 2020 21:381

    Content type: Research article

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  39. Despite its established association with chronic kidney disease (CKD) the role of myosin-9 (MYH9) gene variation on transplanted kidney function remains unknown. This study aimed at evaluating the effect of donor...

    Authors: Joanna Pazik, Monika Oldak, Dominika Oziębło, Dominika Dęborska Materkowska, Anna Sadowska, Jacek Malejczyk and Magdalena Durlik

    Citation: BMC Nephrology 2020 21:380

    Content type: Research article

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  40. Concentration of the urine is primarily regulated via vasopressin dependent aquaporin-2 water channels in the apical membrane of kidney principal cells. It is unclear whether urine concentration ability in ADP...

    Authors: M. H. Malmberg, F. H. Mose, E. B. Pedersen and J. N. Bech

    Citation: BMC Nephrology 2020 21:379

    Content type: Research article

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  41. Uricemia dramatically rises with the stage of chronic kidney disease (CKD) and correlates with its mortality. Hemodialysis (HD) being the most used treatment at the end stage in sub-Saharan Africa, we sought t...

    Authors: Marie Doualla, Jan René Nkeck, Marie Patrice Halle, Félicité Kamdem, Aude Ingrid Agouak, Mickael Essouma, Yonathan Batchama Lobe and Gloria Ashuntantang

    Citation: BMC Nephrology 2020 21:378

    Content type: Research article

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  42. Older haemodialysis patients accompany a high burden of functional impairment, limited life expectancy, and healthcare utilization. This meta-analysis aimed to evaluate how various risk factors influenced the ...

    Authors: Yu-Huan Song, Guang-Yan Cai, Yue-Fei Xiao and Xiang-Mei Chen

    Citation: BMC Nephrology 2020 21:377

    Content type: Research article

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  43. Primary coenzyme Q10 (CoQ10) deficiency of genetic origin is one of a few treatable focal segmental glomerulosclerosis (FSGS). Renal morphologic evidence for COQ8B mutation and CoQ10 deficiencies of other gene mu...

    Authors: Yujiro Maeoka, Toshiki Doi, Masaho Aizawa, Kisho Miyasako, Shuma Hirashio, Yukinari Masuda, Yoshihito Kishita, Yasushi Okazaki, Kei Murayama, Toshiyuki Imasawa, Shigeo Hara and Takao Masaki

    Citation: BMC Nephrology 2020 21:376

    Content type: Case report

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  44. Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discon...

    Authors: Josefine Thomsen, Ulrik Sprogøe and Palle Toft

    Citation: BMC Nephrology 2020 21:375

    Content type: Research article

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  45. After kidney transplantation non-adherence and inadequate self-management undermine clinical outcomes and quality of life. Both have been demonstrated to be substantial in all age groups. However, intervention...

    Authors: Denise Karin Beck, Mirjam Tielen, Marloes Rechards, Reinier Timman, Charlotte Boonstra, Josette Versteegh, Jacqueline van de Wetering, Robert Zietse, Teun van Gelder, Willem Weimar, Jan van Saase, Jan van Busschbach and Emma Kay Massey

    Citation: BMC Nephrology 2020 21:374

    Content type: Study protocol

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  46. Acute kidney injury (AKI) remains a frequent complication in children undergoing hematopoietic stem cell transplantation (HSCT) and an independent risk factor of the patient’s survival and a prognostic factor ...

    Authors: Daishi Hirano, Daisuke Kakegawa, Saori Miwa, Chisato Umeda, Yoichi Takemasa, Ai Tokunaga, Yuhei Kawakami and Akira Ito

    Citation: BMC Nephrology 2020 21:373

    Content type: Research article

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  47. To determine the prevalence, distribution, concordance and associations of chronic kidney disease (CKD) determined by five glomerular filtration rate (GFR) formulae in urban black residents of Cape Town.

    Authors: Nasheeta Peer, Jaya George, Carl Lombard, Krisela Steyn, Naomi Levitt and Andre-Pascal Kengne

    Citation: BMC Nephrology 2020 21:372

    Content type: Research article

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  48. Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular...

    Authors: Hidefumi Wakashin, Jurgen Heymann, Hila Roshanravan, Parnaz Daneshpajouhnejad, Avi Rosenberg, Myung Kyun Shin, Maarten Hoek and Jeffrey B. Kopp

    Citation: BMC Nephrology 2020 21:371

    Content type: Research article

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  49. When we encounter patients who present with both a neck mass and nephrotic syndrome, both malignancy and Kimura’s disease need to be evaluated as the therapeutic strategies differ vastly between them.

    Authors: Hayato Fujioka, Tsutomu Koike, Teruhiko Imamura, Kota Kakeshita, Hidenori Yamazaki, Hideharu Abe, Takahiko Nakajima and Koichiro Kinugawa

    Citation: BMC Nephrology 2020 21:369

    Content type: Case report

    Published on:

  50. IgA nephropathy is the most common glomerulonephritis. Secondary IgA nephropathy complicated with systemic diseases, including psoriasis, is also often reported. Generalized pustular psoriasis is a form of pso...

    Authors: Yuka Segawa, Ryo Ishida, Fuminao Kanehisa, Kunihiro Nakai, Mari Morimoto, Masafumi Seno, Mayuka Nakayama, Tetsuro Kusaba, Norito Katoh and Keiichi Tamagaki

    Citation: BMC Nephrology 2020 21:366

    Content type: Case report

    Published on:

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