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  1. Content type: Research article

    Angiopoietin-like-3 (Angptl3) knockout is known for its protective effects on podocyte injury and proteinuria in the early stage of adriamycin (ADR) nephropathy. The current study re-evaluated the renoprotecti...

    Authors: Rufeng Dai, Haimei Liu, Xinli Han, Junchao Liu, Yihui Zhai, Jia Rao, Qian Shen and Hong Xu

    Citation: BMC Nephrology 2019 20:185

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  2. Content type: Research article

    Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study...

    Authors: Jia-Sian Hou, Yu-Li Lin, Chih-Hsien Wang, Yu-Hsien Lai, Chiu-Huang Kuo, Yi-Maun Subeq and Bang-Gee Hsu

    Citation: BMC Nephrology 2019 20:184

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  3. Content type: Research article

    Accurate prediction of reference ranges of renal lengths facilitates clinical decision making. Currently a single renal-length-reference chart is used for both kidneys, which is solely based on the age of the ...

    Authors: W. D. Duminda, K. G. Pathirana, M. U. J. Fernando, R. A. N. K. K. Samarasinghe, W. D. H. A. Ananda, K. S. P. Silva, C. K. Dissanayake and P. K. B. Mahesh

    Citation: BMC Nephrology 2019 20:183

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  4. Content type: Research article

    Acute kidney injury (AKI) is common after heart surgery. Neutrophil gelatinase-associated lipocalin (NGAL) is produced in injured kidney. NGAL has been used as an early plasma biomarker for AKI in patients und...

    Authors: Arie Passov, Liisa Petäjä, Marjut Pihlajoki, Ulla-Stina Salminen, Raili Suojaranta, Antti Vento, Sture Andersson, Ville Pettilä, Alexey Schramko and Eero Pesonen

    Citation: BMC Nephrology 2019 20:182

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  5. Content type: Research article

    Glucose is a primary osmotic agent in peritoneal dialysis (PD) solutions, but its long-term use causes structural alteration of the peritoneal membrane (PM). Hyperbranched polyglycerol (HPG) is a promising alt...

    Authors: Bin Liu, Shijian Feng, Ghida Dairi, Qiunong Guan, Irina Chafeeva, Hao Wang, Richard Liggins, Gerald da Roza, Jayachandran N. Kizhakkedathu and Caigan Du

    Citation: BMC Nephrology 2019 20:181

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  6. Content type: Case report

    Peritonitis is a common cause of catheter removal and mortality in the patient undergoing peritoneal dialysis (PD). Various pathogenic organisms have been identified as the etiology of PD-related peritonitis, ...

    Authors: Panai Song, Jun Deng, Tao Hou, Xiao Fu, Lei Zhang, Lin Sun and Yinghong Liu

    Citation: BMC Nephrology 2019 20:180

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  7. Content type: Research article

    Reports on vitamin C in HD patients have shown effects of vitamin C deficiency in association with scurvy symptoms. Dialyzability of water soluble vitamins is high, and substantial losses in those who are dial...

    Authors: Jochen G. Raimann, Samer R. Abbas, Li Liu, Brett Larive, Gerald Beck, Peter Kotanko, Nathan W. Levin and Garry Handelman

    Citation: BMC Nephrology 2019 20:179

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  8. Content type: Research article

    Adherence to phosphate binder treatment is important to prevent high serum phosphate level in chronic dialysis patients. We therefore wanted to investigate patient knowledge, beliefs about and adherence to pho...

    Authors: Bodil Jahren Hjemås, Katrine Bøvre, Liv Mathiesen, Jonas Christoffer Lindstrøm and Kathrin Bjerknes

    Citation: BMC Nephrology 2019 20:178

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  9. Content type: Research article

    A classification tree model (CT-PIRP) was developed in 2013 to predict the annual renal function decline of patients with chronic kidney disease (CKD) participating in the PIRP (Progetto Insufficienza Renale P...

    Authors: Dino Gibertoni, Paola Rucci, Marcora Mandreoli, Mattia Corradini, Davide Martelli, Giorgia Russo, Elena Mancini and Antonio Santoro

    Citation: BMC Nephrology 2019 20:177

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  10. Content type: Research article

    Inflammation is more common among African Americans (AAs), and it is associated with frailty, poor physical performance, and mortality in community-dwelling older adults. Given the elevated inflammation levels...

    Authors: Prakriti Shrestha, Christine E. Haugen, Nadia M. Chu, Ashton Shaffer, Jacqueline Garonzik-Wang, Silas P. Norman, Jeremy D. Walston, Dorry L. Segev and Mara A. McAdams-DeMarco

    Citation: BMC Nephrology 2019 20:176

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  11. Content type: Research article

    The effect of a kidney transplant on a recipient extends beyond the restoration of kidney function. However, there is limited qualitative analysis of recipient perspectives on life following transplantation, p...

    Authors: Emily L. Tucker, Abigail R. Smith, Mark S. Daskin, Hannah Schapiro, Sabrina M. Cottrell, Evelyn S. Gendron, Peg Hill-Callahan, Alan B. Leichtman, Robert M. Merion, Stephen J. Gill and Kayse Lee Maass

    Citation: BMC Nephrology 2019 20:175

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  12. Content type: Technical advance

    Increased morbidity and mortality are well documented in Status 7(inactive list) patients. Delays in transplantation secondary to prolonged periods on inactive status also negatively impacts transplant outcome...

    Authors: Ashish Kataria, Madan Gowda, Brian Paul Lamphron, Kabir Jalal, Rocco C. Venuto and Aijaz A. Gundroo

    Citation: BMC Nephrology 2019 20:174

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  13. Content type: Case report

    Nephronophthisis (NPHP) is an autosomal recessive hereditary disease with highly variable clinical characteristics for which 20 genes (NPHP1–20) have been identified. NPHP1 is the major subtype leading to pediatr...

    Authors: Yiting Wang, Feng Chen, Jiali Wang, Yingwang Zhao and Fang Liu

    Citation: BMC Nephrology 2019 20:173

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  14. Content type: Research article

    Reduced muscle strength and physical performance are prevalent in patients of maintenance hemodialysis (MHD), and deleterious changes in these parameters are associated with increased mortality.

    Authors: Yoshifumi Moriyama, Masahiko Hara, Sae Aratani, Hideaki Ishikawa, Kenichi Kono and Masatake Tamaki

    Citation: BMC Nephrology 2019 20:172

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  15. Content type: Research article

    Steroidal mineralocorticoid receptor antagonists (MRAs) are recommended for the treatment of heart failure (HF) and resistant hypertension, both common comorbidities in patients with diabetes and chronic kidne...

    Authors: Michael Blankenburg, Anne-Kathrin Fett, Seline Eisenring, Gabriele Haas and Alain Gay

    Citation: BMC Nephrology 2019 20:171

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  16. Content type: Research article

    Physicians are faced with a growing number of patients after renal transplantation undergoing graft-unrelated surgery. So far, little is known about the postoperative restitution of graft function and the risk...

    Authors: Ann-Kathrin Lederer, Dominic Haffa, Philipp Felgendreff, Frank Makowiec, Stefan Fichtner-Feigl, Roman Huber and Lampros Kousoulas

    Citation: BMC Nephrology 2019 20:170

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  17. Content type: Research article

    The putative benefits of cinacalcet therapy for management of secondary hyperparathyroidism (SHPT) are thought to be most manifested when patients are taking it consistently and as prescribed. Real-world descr...

    Authors: Douglas S. Fuller, David Hallett, Paul J. Dluzniewski, Bruno Fouqueray, Michel Jadoul, Hal Morgenstern, Friedrich K. Port, Francesca Tentori and Ronald L. Pisoni

    Citation: BMC Nephrology 2019 20:169

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  18. Content type: Case report

    Nephrogenic diabetes insipidus (DI) secondary to a urinary tract obstruction is a rare condition. Herein, we report a case of partial nephrogenic DI due to obstructive uropathy in a patient with Castleman’s di...

    Authors: Minah Kim, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim and Chang Seong Kim

    Citation: BMC Nephrology 2019 20:168

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  19. Content type: Research article

    The influence of pre- or postprandial administration on pharmacokinetics of cyclosporine is supposed to be less in gel-based formulations than in microemulsions. This study was designed to investigate the infl...

    Authors: Anja Gäckler, Sebastian Dolff, Hana Rohn, Johannes Korth, Benjamin Wilde, Ute Eisenberger, Anna Mitchell, Andreas Kribben and Oliver Witzke

    Citation: BMC Nephrology 2019 20:167

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  20. Content type: Research article

    Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain...

    Authors: Silje Småbrekke, Henrik Schirmer, Toralf Melsom, Marit Dahl Solbu and Bjørn Odvar Eriksen

    Citation: BMC Nephrology 2019 20:166

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  22. Content type: Research article

    There is increasing awareness that, besides patient survival, Quality of Life (QOL) is a relevant outcome factor for patients who have a chronic disease. In haemodialysis (HD) patients, intradialytic hypotensi...

    Authors: Johanna Kuipers, Jurjen K. Oosterhuis, Wolter Paans, Wim P. Krijnen, Carlo A. J. M. Gaillard, Ralf Westerhuis and Casper F. M. Franssen

    Citation: BMC Nephrology 2019 20:164

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  23. Content type: Research article

    To describe the quality of life of adolescents initiating haemodialysis, to determine the factors associated with quality of life, and to assess coping strategies and their impact on quality of life.

    Authors: Stéphanie Clavé, Michel Tsimaratos, Mohamed Boucekine, Bruno Ranchin, Rémi Salomon, Olivier Dunand, Arnaud Garnier, Annie Lahoche, Marc Fila, Gwenaelle Roussey, Francoise Broux, Jérome Harambat, Sylvie Cloarec, Soraya Menouer, Georges Deschenes, Isabelle Vrillon…

    Citation: BMC Nephrology 2019 20:163

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  24. Content type: Research article

    Antineutrophil cytoplasmic antibody associated vasculitis (AAV) is a group of diseases associated in most cases with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs). Rituximab- based remission i...

    Authors: L. Caroti, C. L. Cirami, L. Di Maria, A. Larti, P. Carta, E. Dervishi, S. Farsetti, A. Tsalouchos, L. Novelli and E. E. Minetti

    Citation: BMC Nephrology 2019 20:162

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  25. Content type: Research article

    Despite the good prognosis in patients with transplant organs, limited evidence is available on how immunosuppressants affect pregnancy. The aim of this study was to determine whether immunosuppressant use aff...

    Authors: Bo Hyon Yun, Dong Jin Joo, Seok Kyo Seo, Si Hyun Cho, Young Sik Choi and Byung Seok Lee

    Citation: BMC Nephrology 2019 20:161

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  26. Content type: Case report

    Unintentional renal artery occlusion after endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm remains one of the most unfavorable complications. Renal salvage options include percutaneous transl...

    Authors: Atsuko Uehara, Tomo Suzuki, Soichiro Hase, Hirofumi Sumi, Satoshi Hachisuka, Eisuke Fujimoto, Kouichirou Aida, Ryuto Nakazawa, Hideo Sasaki, Junki Koike, Tatsuya Chikaraishi, Yugo Shibagaki and Yuhji Marui

    Citation: BMC Nephrology 2019 20:160

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  27. Content type: Research article

    To assess reasons for continuing practice variation in the management of childhood nephrotic syndrome despite expert reviews and guidelines, we are conducting a longitudinal cohort study in children with gluco...

    Authors: Susan M. Samuel, Allison Dart, Guido Filler, Martin Bitzan, Maury Pinsk, Cherry Mammen, Alberto Nettel-Aguirre, Maneka A. Perinpanayagam, Tomoko Takano, Rahul Chanchlani and Michael Zappitelli

    Citation: BMC Nephrology 2019 20:159

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  28. Content type: Research article

    Pirfenidone is an orally active drug used for the treatment of idiopathic pulmonary fibrosis to slow loss of lung function; it acts mainly through an antifibrotic effect but also possesses antioxidant and anti...

    Authors: Ixchel Lima-Posada, Francesco Fontana, Rosalba Pérez-Villalva, Nathan Berman-Parks and Norma A. Bobadilla

    Citation: BMC Nephrology 2019 20:158

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  29. Content type: Case report

    Haemolytic uraemic syndrome (HUS) is a thrombotic microangiopathy (TMA) characterized by predominant renal involvement. Several types of HUS can be distinguished: the most frequent « typical » HUS, due to shig...

    Authors: Stéphane Bally, Jacques Fourcade and Véronique Frémeaux-Bacchi

    Citation: BMC Nephrology 2019 20:157

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  30. Content type: Research article

    As patients on daily hemodialysis (DHD) have heterogeneous profiles, DHD benefit in terms of survival is still debated. The aim of this study was to compare DHD practices in France and in Australia and New Zea...

    Authors: Adélaïde Pladys, Sahar Bayat, Cécile Couchoud, Cécile Vigneau and Stephen McDonald

    Citation: BMC Nephrology 2019 20:156

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  31. Content type: Research article

    It has been reported that people living with HIV in West Africa exhibited the highest risks for chronic kidney disease (CKD) in the world. Here, we aimed at determining the CKD frequency and changes in kidney ...

    Authors: Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien B. Sawadogo, Eric Delaporte, Nicolas Meda, Sophie Limou and Amandine Cournil

    Citation: BMC Nephrology 2019 20:155

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  32. Content type: Research article

    Glucocorticoids (GCs) are frequently used to treat glomerular diseases but are associated with multiple adverse effects including hypothalamic-pituitary-adrenal axis inhibition that can lead to adrenal insuffi...

    Authors: Alvin H. K. Karangizi, May Al-Shaghana, Sarah Logan, Sherwin Criseno, Rachel Webster, Kristien Boelaert, Peter Hewins and Lorraine Harper

    Citation: BMC Nephrology 2019 20:154

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  33. Content type: Research article

    Dialysis patients are frequently exposed to Staphylococcus aureus due to stays in dialysis centers, hospitals or rest homes. The hemodialysis vascular access is a potential entry site for S. aureus, in particular...

    Authors: Matthias Scheuch, Sabrina Freiin von Rheinbaben, Antje Kabisch, Jonas Engeßer, Susanne Ahrendt, Thomas Dabers, Christian Kohler, Silva Holtfreter, Barbara M. Bröker and Sylvia Stracke

    Citation: BMC Nephrology 2019 20:153

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  34. Content type: Research article

    In patients with end stage renal disease (ESRD), left ventricular (LV) hypertrophy with impaired LV function, which is called uremic cardiomyopathy (UC) is often observed. The UC historically has been consider...

    Authors: Tomasz Zapolski, Jacek Furmaga, Andrzej P. Wysokiński, Anna Wysocka, Sławomir Rudzki and Andrzej Jaroszyński

    Citation: BMC Nephrology 2019 20:152

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  35. Content type: Research article

    Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation st...

    Authors: Naren Kumar Surendra, Mohd Rizal Abdul Manaf, Lai Seong Hooi, Sunita Bavanandan, Fariz Safhan Mohamad Nor, Shahnaz Shah Firdaus Khan, Loke Meng Ong and Abdul Halim Abdul Gafor

    Citation: BMC Nephrology 2019 20:151

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  36. Content type: Research article

    The serum immunoglobulin A (IgA)/C3 ratio is considered to be an effective predictor of IgA nephropathy (IgAN). This study sought to explore the diagnostic value of the IgA/C3 ratio in IgAN among primary glome...

    Authors: Wen-yu Gong, Man Liu, Dan Luo, Fan-na Liu, Liang-hong Yin, Yuan-qing Li, Jun Zhang and Hui Peng

    Citation: BMC Nephrology 2019 20:150

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  37. Content type: Study protocol

    Tunnelled dialysis catheter (TC) infections are a major health complication and are associated with increased antibiotic consumption, hospital stays, health costs and mortality. Experimental data provide evide...

    Authors: Julien Aniort, Aurélien Piraud, Mireille Adda, Bruno Perreira, Marc Bouiller, Jacques Fourcade, Abdallah Guerraoui, Emilie Kalbacher, Thierry Krumel, Hélène Leray Moragues, Damien Thibaudin, Carlos Gustavo Vela, Guillaume Vernin, Hugo Weclawiak, Lise Bernard, Anne Elisabeth Heng…

    Citation: BMC Nephrology 2019 20:149

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  38. Content type: Guidelines

    Autosomal Dominant Polycystic Kidney Disease (ADPKD) is thought to affect about 1 in 1000 people in the UK. ADPKD causes a progressive decline in kidney function, with kidney failure tending to occur in middle...

    Authors: Jan Dudley, Paul Winyard, Matko Marlais, Oliver Cuthell, Tess Harris, Jiehan Chong, John Sayer, Daniel P. Gale, Lucy Moore, Kay Turner, Sarah Burrows and Richard Sandford

    Citation: BMC Nephrology 2019 20:148

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  39. Content type: Research article

    Post transplantation diabetes mellitus (PTDM) is a common and serious complication after renal transplantation with significant morbidity and mortality. Metformin has proven benefits in the general population ...

    Authors: Basil Alnasrallah, Tze Liang Goh, Lai Wan Chan, Paul Manley and Helen Pilmore

    Citation: BMC Nephrology 2019 20:147

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  40. Content type: Research article

    Fewer trainees are choosing to pursue nephrology. Only 60.1% of positions filled in the 2018 fellowship Match, which is concerning given the rising prevalence of end-stage kidney disease. Identifying factors i...

    Authors: Devika Nair, Kurtis A. Pivert, Adrian Baudy IV and Charuhas V. Thakar

    Citation: BMC Nephrology 2019 20:146

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  41. Content type: Research article

    The invention of an effective kidney preservation solution capable of prolonging harvested kidney viability is the core of kidney transplantation procedure. Researchers have been working on upgrading the prese...

    Authors: Sherif Khedr, Oleg Palygin, Tengis S. Pavlov, Gregory Blass, Vladislav Levchenko, Ammar Alsheikh, Michael W. Brands, Ashraf El-Meanawy and Alexander Staruschenko

    Citation: BMC Nephrology 2019 20:145

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  42. Content type: Research article

    Health-related quality of life (HRQoL) is an important component of patient-centered outcomes and a useful parameter for monitoring quality of care. We assessed HRQoL, its determinants, and associations with m...

    Authors: Ming Pei, Rute Aguiar, Agneta A. Pagels, Olof Heimbürger, Peter Stenvinkel, Peter Bárány, Charlotte Medin, Stefan H. Jacobson, Britta Hylander, Bengt Lindholm and Abdul Rashid Qureshi

    Citation: BMC Nephrology 2019 20:144

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  43. Content type: Research article

    To support effective self-management after kidney transplantation, a holistic nurse-led self-management support intervention was developed using the Intervention Mapping approach. The primary aim was to evalua...

    Authors: Janet M. J. Been-Dahmen, Denise K. Beck, Mariëlle A. C. Peeters, Heleen van der Stege, Mirjam Tielen, Marleen C. van Buren, Erwin Ista, AnneLoes van Staa and Emma K. Massey

    Citation: BMC Nephrology 2019 20:143

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  44. Content type: Research article

    Self-management intervention aims to facilitate an individual’s ability to make lifestyle changes. The effectiveness of this intervention in non-dialysis patients with chronic kidney disease (CKD) is limited. ...

    Authors: Suyuan Peng, Jiawei He, Jiasheng Huang, Longwei Lun, Jiahao Zeng, Shan Zeng, La Zhang, Xusheng Liu and Yifan Wu

    Citation: BMC Nephrology 2019 20:142

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  45. Content type: Research article

    Meprin metalloproteases are abundantly expressed in the brush border membranes of kidney proximal tubules and small intestines. Meprins are also expressed in podocytes and leukocytes (monocytes and macrophages...

    Authors: Jessica Gooding, Lei Cao, Courtney Whitaker, Jean-Marie Mwiza, Mizpha Fernander, Faihaa Ahmed, Zach Acuff, Susan McRitchie, Susan Sumner and Elimelda Moige Ongeri

    Citation: BMC Nephrology 2019 20:141

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  46. Content type: Research article

    Chronic kidney disease (CKD) is a public health problem worldwide, and proteinuria is a well-established marker of disease progression in CKD patients. Propolis, a natural resin produced by bees from plant mat...

    Authors: Marcelo Augusto Duarte Silveira, Flávio Teles, Andressa A. Berretta, Talita R. Sanches, Camila Eleutério Rodrigues, Antonio Carlos Seguro and Lúcia Andrade

    Citation: BMC Nephrology 2019 20:140

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  47. Content type: Research article

    An increased incidence of thromboembolic events (TE) are reported in nephrotic syndrome (NS) leading to recommendations for prophylactic anticoagulation (PAC). However, as no randomized clinical trial has esta...

    Authors: Sarah Kelddal, Karen Marie Nykjær, Jon Waarst Gregersen and Henrik Birn

    Citation: BMC Nephrology 2019 20:139

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  48. Content type: Research article

    Apparent treatment-resistant hypertension (aTRH) is a common condition associated with risk of cardiovascular events. However, the risk of cardiovascular mortality associated with aTRH in the US population is ...

    Authors: Katerina R. Kaczmarski, Stephen M. Sozio, Jingsha Chen, Yingying Sang and Tariq Shafi

    Citation: BMC Nephrology 2019 20:138

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  49. Content type: Research article

    Despite an increasing number of older people commencing dialysis the impact of dialysis on their quality of life and survival, remains unclear. The Dialysis Outcomes in those aged over 65 years or older study ...

    Authors: Bronwen McNoe, John B. W. Schollum, Sarah Derrett, Mark R. Marshall, Andrew Henderson, Ari Samaranayaka and Robert J. Walker

    Citation: BMC Nephrology 2019 20:137

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  50. Content type: Research article

    The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represe...

    Authors: Hayley Bennett, Phil McEwan, Karina Hamilton and Karl O’Reilly

    Citation: BMC Nephrology 2019 20:136

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