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  1. Content type: Research article

    Hyperphosphatemia is associated with vascular calcification and bone mineral disorders and is a major concern among patients with chronic kidney disease (CKD). However, the relationship between hyperphosphatem...

    Authors: Hongran Moon, Ho Jun Chin, Ki Young Na, Kwon Wook Joo, Yon Su Kim, Sejoong Kim and Seung Seok Han

    Citation: BMC Nephrology 2019 20:362

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  2. Content type: Study protocol

    More than 6200 End Stage Renal Disease patients in the Netherlands are dependent on dialysis, either performed at home or in a dialysis centre. Visiting a dialysis centre three times a week is considered a lar...

    Authors: A. van Eck van der Sluijs, A. A. Bonenkamp, F. W. Dekker, A. C. Abrahams and B. C. van Jaarsveld

    Citation: BMC Nephrology 2019 20:361

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  3. Content type: Research article

    The diagnostic value of serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) expression in patients with primary membranous nephropathy (PMN) has been established. However, the association between sPLA2...

    Authors: Yufeng Liang, Jianxin Wan, Yongping Chen and Yangbin Pan

    Citation: BMC Nephrology 2019 20:360

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  4. Content type: Research article

    Evidences show that around 20% of biosimilar or originator erythropoiesis-stimulating agents (ESAs) users are hyporesponsive. Controversial post-marketing data exist on the predictors of ESA hyporesponsiveness...

    Authors: Ingrasciotta Ylenia, Lacava Viviana, Marcianò Ilaria, Giorgianni Francesco, Tripepi Giovanni, D’ Arrigo Graziella, Chinellato Alessandro, Tari Daniele Ugo, Santoro Domenico and Trifirò Gianluca

    Citation: BMC Nephrology 2019 20:359

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  5. Content type: Research article

    Cardiovascular disease is the most common complication and leading cause of death in maintenance hemodialysis patients. The protection mechanism of hydrogen sulfide (H2S) and the specific role of conventional pro...

    Authors: Ruifang Xiong, Xiangxue Lu, Jinghong Song, Han Li and Shixiang Wang

    Citation: BMC Nephrology 2019 20:358

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  6. Content type: Research article

    Chronic kidney disease (CKD) is often under-recognized and poorly documented via diagnoses, but the extent of under-recognition is not well understood among Medicare beneficiaries. The current study used claim...

    Authors: Clarissa J. Diamantidis, Sarah L. Hale, Virginia Wang, Valerie A. Smith, Sarah Hudson Scholle and Matthew L. Maciejewski

    Citation: BMC Nephrology 2019 20:357

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  7. Content type: Research article

    Pulsatility is an important property of hemodialysis arteriovenous fistulas (AVF) and can be perceived by the fingers as a gradual decrease in strength downstream from the anastomosis along the main trunk of t...

    Authors: Matt Chiung-Yu Chen, Mei-Jui Weng, Misoso Yi-Wen Wu, Yi-Chun Liu and Wen-Che Chi

    Citation: BMC Nephrology 2019 20:356

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  8. Content type: Research article

    Autosomal dominant polycystic kidney disease (ADPKD) is mainly characterised by the development and enlargement of renal cysts that lead to end-stage renal disease (ESRD) in adult patients. Other clinical mani...

    Authors: Riccardo Magistroni, Alessandra Mangolini, Sonia Guzzo, Francesca Testa, Mario R. Rapanà, Renzo Mignani, Giorgia Russo, Francesco di Virgilio and Gianluca Aguiari

    Citation: BMC Nephrology 2019 20:355

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  9. Content type: Research article

    Although immunoglobulin A nephropathy (IgAN) is associated with an increased risk of renal allograft failure, evidences for its treatment, including renin-angiotensin-aldosterone system blockade (RAASB) usage,...

    Authors: Sehoon Park, Chung Hee Baek, Heounjeong Go, Young Hoon Kim, Sang–il Min, Jongwon Ha, Yong Chul Kim, Jung Pyo Lee, Yon Su Kim, Kyung Chul Moon, Su-Kil Park and Hajeong Lee

    Citation: BMC Nephrology 2019 20:354

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  10. Content type: Case report

    17q12 deletion syndrome encompasses a broad constellation of clinical phenotypes, including renal magnesium wasting, maturity-onset diabetes of the young (MODY), renal cysts, genitourinary malformations, and n...

    Authors: Howard J. Li, Catherine Groden, Melanie P. Hoenig, Evan C. Ray, Carlos R. Ferreira, Willam Gahl and Danica Novacic

    Citation: BMC Nephrology 2019 20:353

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  11. Content type: Research article

    Tacrolimus (TAC) is effective in treating membranous nephropathy (MN); however relapses are frequent after treatment cessation. We conducted a randomised controlled trial to examine whether the addition of myc...

    Authors: Aikaterini Nikolopoulou, Marie Condon, Tabitha Turner-Stokes, H. Terence Cook, Neill Duncan, Jack W. Galliford, Jeremy B. Levy, Liz Lightstone, Charles D. Pusey, Candice Roufosse, Thomas D. Cairns and Megan E. Griffith

    Citation: BMC Nephrology 2019 20:352

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  12. Content type: Research article

    Spironolactone can improve endothelial dysfunction in the setting of heart failure and diabetes models. However, its beneficial effect in the cardiovascular system is not clear in the setting of non-diabetic r...

    Authors: Chun-Cheng Wang, An-Sheng Lee, Shu-Hui Liu, Kuan-Cheng Chang, Ming-Yi Shen and Chiz-Tzung Chang

    Citation: BMC Nephrology 2019 20:351

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  13. Content type: Research article

    Lupus nephritis (LN) is an inflammation of the kidneys and is a major cause of mortality in systemic lupus erythaematosus (SLE) patients. In addition, Th17/Treg balance is one of the most important factors tha...

    Authors: Dongdong Fu, Soulixay Senouthai, Junjie Wang and Yanwu You

    Citation: BMC Nephrology 2019 20:350

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  14. Content type: Research article

    High blood pressure is the most significant risk factor for the development and progression of chronic kidney disease (CKD). Lowering blood pressure is a goal to prevent CKD progression. This study of adults w...

    Authors: Jianzhen Zhang, Helen G. Healy, Sree Krishna Venuthurupalli, Ken-Soon Tan, Zaimin Wang, Anne Cameron and Wendy E. Hoy

    Citation: BMC Nephrology 2019 20:348

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  15. Content type: Research article

    Intradialytic blood pressure (BP) measurement is currently the main parameter used for monitoring hemodynamics during hemodialysis (HD). Since BP is dependent on cardiac output and total peripheral resistance,...

    Authors: Keren Doenyas-Barak, Marcia H. F. G. de Abreu, Lucas E. Borges, Helcio A. Tavares Filho, Feng Yunlin, Zou Yurong, Nathan W. Levin, Allen M. Kaufman, Shay Efrati, David Pereg, Ilya Litovchik, Shmuel Fuchs and Sa’ar Minha

    Citation: BMC Nephrology 2019 20:347

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  16. Content type: Study protocol

    Kidney transplantation is the optimal treatment in end stage renal disease but the allograft survival is still hampered by immune reactions against the allograft. This process is driven by the recognition of a...

    Authors: Constantin Aschauer, Kira Jelencsics, Karin Hu, Andreas Heinzel, Julia Vetter, Thomas Fraunhofer, Susanne Schaller, Stephan Winkler, Lisabeth Pimenov, Guido A. Gualdoni, Michael Eder, Alexander Kainz, Heinz Regele, Roman Reindl-Schwaighofer and Rainer Oberbauer

    Citation: BMC Nephrology 2019 20:346

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  17. Content type: Research article

    Patients with end-stage renal disease have a higher risk of death from cardiovascular events, which can be mainly attributed to coronary artery calcification (CAC). Wnt signaling is involved in vascular develo...

    Authors: Tzung-Yo Ho, Nai-Ching Chen, Chih-Yang Hsu, Chien-Wei Huang, Po-Tsang Lee, Kang-Ju Chou, Hua-Chang Fang and Chien-Liang Chen

    Citation: BMC Nephrology 2019 20:345

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  18. Content type: Research article

    Patient-reported outcome measures (PROMs) are becoming increasingly important in healthcare. In nephrology, there is no agreement on which chronic kidney disease (CKD) symptom questionnaire to use. Therefore, ...

    Authors: Esmee M. van der Willik, Yvette Meuleman, Karen Prantl, Giel van Rijn, Willem Jan W. Bos, Frans J. van Ittersum, Hans A. J. Bart, Marc H. Hemmelder and Friedo W. Dekker

    Citation: BMC Nephrology 2019 20:344

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  19. Content type: Research article

    Neighborhood racial mix is associated with dialysis facility performance metrics and mortality outcomes in patients on hemodialysis. We explored the association of neighborhood racial mix with emergency depart...

    Authors: Ladan Golestaneh, Atessa Farzami, Chikeluba Madu, Tanya Johns, Michal L. Melamed and Keith C. Norris

    Citation: BMC Nephrology 2019 20:343

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  20. Content type: Research article

    Approximately 4–6% of incident end stage renal disease (ESRD) patients in the U.S. recover enough kidney function to discontinue dialysis but there is considerable geographic variation. We undertook this study...

    Authors: Zijin Chen, Benjamin J. Lee, Charles E. McCulloch, Nilka Ríos Burrows, Michael Heung, Raymond K. Hsu, Meda E. Pavkov, Neil R. Powe, Rajiv Saran, Vahakn Shahinian and Chi-yuan Hsu

    Citation: BMC Nephrology 2019 20:342

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  21. Content type: Case report

    Kidney transplantation is the treatment of choice in end-stage renal disease due to Alport syndrome (AS). However, the chances of finding an adequate living-related donor in AS are much worse compared to non-h...

    Authors: Friederike Petzold, Anette Bachmann, Carsten Bergmann, Udo Helmchen and Jan Halbritter

    Citation: BMC Nephrology 2019 20:340

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  22. Content type: Research article

    Microscopic polyangiitis (MPA) is a systemic autoimmune disease, and renal involvement is frequently present in MPA. MPA patients with renal involvement may have a worse prognosis. In this study, we aimed to e...

    Authors: Jia Shi, Qing Shen, Xue-Mei Chen and Xiao-Gang Du

    Citation: BMC Nephrology 2019 20:339

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  23. Content type: Research article

    Sleep disturbance is common among chronic haemodialysis patients, which leads to poor quality of life, in addition to increased instances of morbidity and mortality. Hypervolemia has been linked to sleep probl...

    Authors: Sethanant Sethakarun, Sutachard Bijaphala, Chagriya Kitiyakara, Sarinya Boongird, Pariya Phanachet, Sirimon Reutrakul, Kwanchai Pirojsakul and Arkom Nongnuch

    Citation: BMC Nephrology 2019 20:211

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  24. Content type: Research article

    Chronic Kidney Disease (CKD) of uncertain origin (CKDu) has affected North Central Province (Anuradhapura and Polonnaruwa districts) of Sri Lanka. The cause is still unknown. The objective of this study was to...

    Authors: Asanga Venura Ranasinghe, Gardiye Weligamage Gamini Priyantha Kumara, Ranamuka Henayage Karunarathna, Ambepitiyawaduge Pubudu De Silva, Korale Gedara Dilini Sachintani, Jayaprakara Mudiyanselage Chathurika Nayani Gunawardena, Sembu Kuttige Champika Ruwan Kumari, Mohamed Shali Fathima Sarjana, Janaka Sri Chandraguptha and Mannikawadumesthri Vipula Chandu De Silva

    Citation: BMC Nephrology 2019 20:338

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  25. Content type: Case report

    Autosomal dominant polycystic kidney disease (ADPKD) may manifest non-nephrotic range proteinuria, but is rarely complicated with nephrotic syndrome. Limited number of reports describe the histology of ADPKD w...

    Authors: Yasuhiro Oda, Naoki Sawa, Eiko Hasegawa, Hiroki Mizuno, Masahiro Kawada, Akinari Sekine, Rikako Hiramatsu, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii and Yoshifumi Ubara

    Citation: BMC Nephrology 2019 20:337

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  26. Content type: Research article

    Though the roles of microRNAs (miRNAs) in renal diseases have been extensively investigated, a thorough screening and comparison of miRNAs among different types of chronic kidney disease (CKD) has never been p...

    Authors: Jianwen Yu, Chaolun Yu, Boya Feng, Xiaojiang Zhan, Ning Luo, Xueqing Yu and Qin Zhou

    Citation: BMC Nephrology 2019 20:336

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  27. Content type: Case report

    The nature of immunoglobulin M (IgM) nephropathy has been controversial for a long time, but it is now considered an independent disease like immunoglobulin A nephropathy. IgM nephropathy has been known to hav...

    Authors: Kyoung Sook Park, Ea Wha Kang and Jeong Hae Kie

    Citation: BMC Nephrology 2019 20:335

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  28. Content type: Case report

    The value of ANCA positivity in the setting of systemic lupus erythematous and their pathogenicity remains uncertain.

    Authors: Marie Lemerle, Anne-Sophie Garnier, Anne Croue, Alain Chevailler, Jean-Paul Saint-André, Jean-François Subra, Jean-François Augusto and Julien Demiselle

    Citation: BMC Nephrology 2019 20:334

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  29. Content type: Research article

    Immunosuppressive agents have been widely used in the treatment of IgA nephropathy (IgAN), but the efficacy and safety remain controversial. The recent STOP-IgAN and TESTING studies have again focused attentio...

    Authors: Zheng Zhang, Yue Yang, Shi-min Jiang and Wen-ge Li

    Citation: BMC Nephrology 2019 20:333

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  30. Content type: Research article

    Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies....

    Authors: Li Xian, Dandan Dong, Jiamei Luo, Ling Zhuo, Ke Li, Ping Zhang, Wei Wang, Ying Xu, Gang Xu, Li Wang and Guisen Li

    Citation: BMC Nephrology 2019 20:332

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  31. Content type: Research article

    Oedema, characterized by accumulation of extracellular water (ECW), is one of the major clinical manifestations in children suffering from nephrotic syndrome (NS).

    Authors: Steven Brantlov, Lars Jødal, René Frydensbjerg Andersen, Aksel Lange, Søren Rittig and Leigh C. Ward

    Citation: BMC Nephrology 2019 20:331

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  32. Content type: Case report

    Proteinuria is a common clinical presentation, the diagnostic workup for which involves many non-invasive and invasive investigations. We report on two siblings that highlight the clinically relevant functiona...

    Authors: Kushani Jayasinghe, Susan M. White, Peter G. Kerr, Duncan MacGregor, Zornitza Stark, Ella Wilkins, Cas Simons, Andrew Mallett and Catherine Quinlan

    Citation: BMC Nephrology 2019 20:330

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  33. Content type: Research article

    A survival advantage associated with obesity has often been described in dialysis patients. The association of higher body mass index (BMI) with mortality and renal replacement therapy (RRT) in preterminal chr...

    Authors: Zaimin Wang, Jianzhen Zhang, Samuel Chan, Anne Cameron, Helen G. Healy, Sree K. Venuthurupalli, Ken-Soon Tan and Wendy E. Hoy

    Citation: BMC Nephrology 2019 20:329

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  34. Content type: Research article

    Focal segmental lesions (FSLs) are not uncommon in idiopathic membranous nephropathy (IMN). The reported percentage of IMN patients with focal segmental glomerulosclerosis (FSGS) lesions varies widely between ...

    Authors: Hong-Guang He, Chao-Qing Wu, Kun Ye, Chun Zeng, Yi-Yun Huang, Shu-Wen Luo, Wu Yin, Qiu-Rong Ye and Xiao-Mei Peng

    Citation: BMC Nephrology 2019 20:328

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  35. Content type: Research article

    Studies have reported conflicting findings on the infection risk posed by intravenous iron supplementation among hemodialysis (HD) patients. We used a novel study design to assess associations between intraven...

    Authors: Chieh-Li Yen, Yu-Sheng Lin, Yueh-An Lu, Hsin-Fu Lee, Cheng-Chia Lee, Ying-Chang Tung, George Kuo, Lung-Sheng Wu, Ya-Chung Tian and Pao-Hsien Chu

    Citation: BMC Nephrology 2019 20:327

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  36. Content type: Case report

    Podocyte infolding glomerulopathy (PIG) is a rare histopathologic finding with global infolding of the podocytes into the glomerular basement membrane (GBM), accompanied by microstructures underneath. Describe...

    Authors: Fabian Wöstmann, Roman-Ulrich Müller, Heike Göbel, Thomas Benzing, Jan U. Becker and Malte P. Bartram

    Citation: BMC Nephrology 2019 20:326

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  37. Content type: Research article

    Patients with cardiovascular disease are at an increased risk of chronic kidney disease (CKD). However, data on incident CKD in patients with multiple vascular comorbidities are insufficient. In this study, we...

    Authors: Saif Al-Shamsi, Abderrahim Oulhaj, Dybesh Regmi and Romona D. Govender

    Citation: BMC Nephrology 2019 20:325

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  38. Content type: Research article

    Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of cardiovascular morbidity and mortality. Impaired left ventricular (LV) global longitudinal strain (GLS) can be a sig...

    Authors: Mats C. H. Lassen, Atif N. Qasim, Tor Biering-Sørensen, Jacob L. T. Reeh, Terry Watnick, Stephen L. Seliger, Huanwen Chen, Mariem A. Sawan, Daniel Nguyen, Yongfang Li, Susie N. Hong and Meyeon Park

    Citation: BMC Nephrology 2019 20:324

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  39. Content type: Research article

    Patients with end-stage renal disease (ESRD) under hemodialysis (HD) are at greater risks of infectious spondylitis (IS), but there is no reliable predictor that facilitate early detection of this relatively r...

    Authors: Kun-Lin Lu, Wen-Hung Huang, Yueh-An Lu, Chan-Yu Lin, Hsin-Hsu Wu, Ching-Wei Hsu, Cheng-Hao Weng, Chao-Yi Wu, I-Wen Wu, Meng-Yu Wu, Tzung-Hai Yen and Huang-Yu Yang

    Citation: BMC Nephrology 2019 20:323

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  40. Content type: Case report

    Glomerulopathy with fibronectin deposits is an autosomal dominant disease associated with proteinuria, hematuria, hypertension and renal function decline. Forty percent of the cases are caused by mutations in FN1

    Authors: Maria Luíza Gonçalves dos Reis Monteiro, Fabiano Bichuette Custódio, Precil Diego Miranda de Menezes Neves, Frederico Moraes Ferreira, Elieser Hitoshi Watanabe, Antônio Marcondes Lerário, Liliane Silvano de Araújo, Bruno Eduardo Pedroso Balbo, Vívian Christine Dourado Pinto, Lívia Maria Gruli Barbosa, Vilmar de Paiva Marques, Juliana Reis Machado, Marlene Antônia Reis and Luiz Fernando Onuchic

    Citation: BMC Nephrology 2019 20:322

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  41. Content type: Research article

    Cardiovascular disease (CVD) events are the main cause of death in long-term hemodialysis (HD) patients. Macrophage colony- stimulating factor (M-CSF) is actively involved in the formation of atherosclerosis a...

    Authors: Xuan Deng, Qian Yang, Yuxi Wang, Yi Yang, Guangchang Pei, Han Zhu, Jianliang Wu, Meng Wang, Zhi Zhao, Huzi Xu, Cheng Zhou, Yi Guo, Ying Yao, Zhiguo Zhang, Wenhui Liao and Rui Zeng

    Citation: BMC Nephrology 2019 20:321

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  42. Content type: Research article

    The challenges in diagnosis of rare renal conditions can negatively impact patient prognosis, quality of life and result in significant healthcare costs. Differential methylation is emerging as an important bi...

    Authors: Katie Kerr, Helen McAneney, Cheryl Flanagan, Alexander P. Maxwell and Amy Jayne McKnight

    Citation: BMC Nephrology 2019 20:320

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  43. Content type: Research article

    Chronic kidney disease (CKD) has been considered as a major health problem in the world. Increasing uric acid (UA) could induce vascular endothelial injury, which is closely related to microinflammation, oxida...

    Authors: Wei Yin, Qiao-Ling Zhou, Sha-Xi OuYang, Ying Chen, Yu-Ting Gong and Yu-Mei Liang

    Citation: BMC Nephrology 2019 20:319

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  44. Content type: Research article

    No study has specifically investigated the duration of continuous renal replacement therapy (CRRT) in patients who experienced acute kidney injury during extracorporeal membrane oxygenation (ECMO) support. How...

    Authors: George Kuo, Shao-Wei Chen, Pei-Chun Fan, Victor Chien-Chia Wu, An-Hsun Chou, Cheng-Chia Lee, Pao-Hsien Chu, Feng-Chun Tsai, Ya-Chung Tian and Chih-Hsiang Chang

    Citation: BMC Nephrology 2019 20:318

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  45. Content type: Research article

    Patients treated with conventional hemodialysis have poor physical performance, explained by insufficient metabolic clearance and shortage of time by time-consuming dialysis. Nocturnal hemodialysis improves me...

    Authors: Manouk Dam, Peter J. M. Weijs, Frans J. van Ittersum and Brigit C. van Jaarsveld

    Citation: BMC Nephrology 2019 20:317

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  46. Content type: Research article

    It is known that one of the leading causes of morbidity in chronic kidney disease (CKD) is the anemic syndrome. Although the pathogenic mechanisms of anemia are multiple, erythropoietin deficiency appears as t...

    Authors: Ailema González-Ortiz, Ricardo Correa-Rotter, Armando Vázquez-Rangel, Olynka Vega-Vega and Ángeles Espinosa-Cuevas

    Citation: BMC Nephrology 2019 20:316

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  47. Content type: Research article

    Performing a kidney biopsy is necessary to accurately diagnose diseases such as glomerulonephritis and tubulointerstitial nephritis, among other such conditions. These conditions predispose patients to chronic...

    Authors: Henrique Pinheiro Konigsfeld, Tatiana Garcia Viana, Suzy Cristine Pereira, Thais Oliveira Claizoni Dos Santos, Gianna Mastroianni Kirsztajn, Agostinho Tavares and Marcelino de Souza Durão Junior

    Citation: BMC Nephrology 2019 20:315

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  48. Content type: Research article

    In kidney transplantation, immunotherapy with thymoglobulin (rATG) has been used to down-regulate the patient immune system. rATG is a powerful immunobiologic drug used to deplete lymphocytes to prevent early ...

    Authors: Marcus Faria Lasmar, Rodrigo Santana Dutra, José Augusto Nogueira-Machado, Raquel A. Fabreti-Oliveira, Raquel Gomes Siqueira and Evaldo Nascimento

    Citation: BMC Nephrology 2019 20:314

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