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  1. IgD multiple myeloma (MM) is a rare subtype of MM and light chain deposition disease (LCDD) outside the kidney is also a rare and has scarcely been reported. We report herein the details of the first reported ...

    Authors: Takafumi Tsushima, Tomo Suzuki, Toshiki Terao, Daisuke Miura, Kentaro Narita, Masami Takeuchi, Akira Shimuzu and Kosei Matsue

    Citation: BMC Nephrology 2021 22:40

    Content type: Case report

    Published on:

  2. The incidence and prevalence of older patients with kidney failure who are dependent on dialysis is increasing. However, observational studies showed limited or no benefit of dialysis on mortality in subgroups...

    Authors: Mathijs van Oevelen, Alferso C. Abrahams, Willem Jan W. Bos, Mariëlle H. Emmelot-Vonk, Simon P. Mooijaart, Merel van Diepen, Brigit C. van Jaarsveld, Anita van Eck van der Sluijs, Carlijn G. N. Voorend and Marjolijn van Buren

    Citation: BMC Nephrology 2021 22:39

    Content type: Study protocol

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  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Rui Huang, Haifen Zhang, Yan Yang, Nina Fang, Qian Liu, Jun Ma, Min Wang, Ling Shi and Xingjuan Tao

    Citation: BMC Nephrology 2021 22:38

    Content type: Correction

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    The original article was published in BMC Nephrology 2021 22:17

  4. This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate...

    Authors: Andrea Ruiz-Alejos, Ben Caplin, J. Jaime Miranda, Neil Pearce and Antonio Bernabé-Ortiz

    Citation: BMC Nephrology 2021 22:37

    Content type: Research article

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  5. Dry weight assessment in hemodialysis (HD) remains a challenge. The aim of the study was to investigate the prevalence of subclinical pulmonary congestion using lung ultrasound (LUS) in maintenance HD patients...

    Authors: Domenico Giannese, Alessandro Puntoni, Adamasco Cupisti, Riccardo Morganti, Enrico Varricchio, Claudia D’Alessandro, Claudia Mannucci, Piera Serio and Maria Francesca Egidi

    Citation: BMC Nephrology 2021 22:36

    Content type: Research article

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  6. While observational studies show an association between serum lipid levels and cardiovascular disease (CVD), intervention studies that examine the preventive effects of serum lipid levels on the development of...

    Authors: Liu Miao, Yan Min, Bin Qi, Chuan-Meng Zhu, Jian-Hong Chen, Guo-Xiong Deng, Yong Wang, Jian-Fei Li and Rong-Shan Li

    Citation: BMC Nephrology 2021 22:35

    Content type: Research article

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  7. IgG4-related kidney disease causes renal impairment of unknown pathogenesis that may progress to kidney failure. Although ectopic germinal centers contribute to the pathogenesis of the head and neck lesions of...

    Authors: Tatsuhito Miyanaga, Keishi Mizuguchi, Satoshi Hara, Takeshi Zoshima, Dai Inoue, Ryo Nishioka, Ichiro Mizushima, Kiyoaki Ito, Hiroshi Fuji, Kazunori Yamada, Yuki Sato, Motoko Yanagita and Mitsuhiro Kawano

    Citation: BMC Nephrology 2021 22:34

    Content type: Case report

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  8. The extent to which patients with End-stage renal disease (ESRD) are at a higher risk of COVID-19-related death is still unclear. Therefore, the aim of this study was to identify the ESRD patients at increased...

    Authors: Hadith Rastad, Hanieh-Sadat Ejtahed, Gita Shafiee, Anis Safari, Ehsan Shahrestanaki, Zeinab Khodaparast, Neda Shafiabadi Hassani, Mohammad Rezaei, Morteza Nazari, Akram Zakani, Mohammad Mahdi Niksima, Mehdi Azimzadeh, Fatemeh Karimi, Ramin Tajbakhsh and Mostafa Qorbani

    Citation: BMC Nephrology 2021 22:33

    Content type: Research article

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  9. Treatment with proteasome inhibitors like carfilzomib in patients with multiple myeloma (MM) can induce thrombotic microangiopathy (TMA) characterized by neurological symptoms, acute kidney injury, hemolysis a...

    Authors: Michael Rassner, Rebecca Baur, Ralph Wäsch, Mario Schiffer, Johanna Schneider, Andreas Mackensen and Monika Engelhardt

    Citation: BMC Nephrology 2021 22:32

    Content type: Case report

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  10. Weight gain (mainly gain of fat mass) occurs quickly after successful kidney transplantation and is associated with metabolic complications (alterations of glycaemic control, hyperlipidaemia). Determinants of ...

    Authors: Karine Moreau, Aurélie Desseix, Christine Germain, Pierre Merville, Lionel Couzi, Rodolphe Thiébaut and Philippe Chauveau

    Citation: BMC Nephrology 2021 22:31

    Content type: Research article

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  11. Patients in maintenance hemodialysis (HD) need a patent vascular access for optimal treatment. The recommended first choice is a native arteriovenous fistula (AVF). Complications of AVF are frequent and includ...

    Authors: Anna Wärme, Henrik Hadimeri, Salmir Nasic and Bernd Stegmayr

    Citation: BMC Nephrology 2021 22:30

    Content type: Research article

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  12. Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinant...

    Authors: Kenan Turgutalp, Savas Ozturk, Mustafa Arici, Necmi Eren, Numan Gorgulu, Mahmut Islam, Sami Uzun, Tamer Sakaci, Zeki Aydin, Erkan Sengul, Bulent Demirelli, Yavuz Ayar, Mehmet Riza Altiparmak, Savas Sipahi, Ilay Berke Mentes, Tuba Elif Ozler…

    Citation: BMC Nephrology 2021 22:29

    Content type: Research article

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  13. Roxadustat has been shown effective in treating patients with anemia due to chronic kidney disease. However, its long-term effect on clinical outcomes and socioeconomic burden and safety remains unclear.

    Authors: Yaling Zhang, Song Ren, Hen Xue, Amanda Y Wang, Yang Zou, Yanrong Cai, Jingdong He, Xiaoling Yuan, Feifei Jiang, Jinxi Wei, Dongmei Yang, Dong He, Shide Hu, Min Lei, Fei Deng, Jin Chen…

    Citation: BMC Nephrology 2021 22:28

    Content type: Study protocol

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  14. Diabetic nephropathy (DN) is a primary complication of diabetes mellitus (DM). The pathology of DN is still vague, and diagnostic accuracy is not enough. This study was performed to identify miRNAs and genes t...

    Authors: Yue Yu, Yuan-Yuan Jia, Meng Wang, Lin Mu and Hong-Jun Li

    Citation: BMC Nephrology 2021 22:27

    Content type: Research article

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  15. Post-Transplant erythrocytosis (PTE) has not been studied in large recent cohorts. In this study, we evaluated the incidence, risk factors, and outcome of PTE with current transplant practices using the presen...

    Authors: Sami Alasfar, Isaac E. Hall, Sherry G. Mansour, Yaqi Jia, Heather R. Thiessen-Philbrook, Francis L. Weng, Pooja Singh, Bernd Schröppel, Thangamani Muthukumar, Sumit Mohan, Rubab F. Malik, Meera N. Harhay, Mona D. Doshi, Enver Akalin, Jonathan S. Bromberg, Daniel C. Brennan…

    Citation: BMC Nephrology 2021 22:26

    Content type: Research article

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  16. Immunoglobulin M (IgM) mesangial deposition in pediatric minimal change disease (MCD) has been reported to be associated with steroid dependence and poor renal outcomes. However, the evidence linking the impac...

    Authors: Cheng-Wen Yang, Fan-Yu Chen, Fu-Pang Chang, Yang Ho, Bo-Sheng Wu, An-Hang Yang, Der-Cherng Tarng and Chih-Yu Yang

    Citation: BMC Nephrology 2021 22:25

    Content type: Research article

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  17. Dent disease is an X-linked form of progressive renal disease. This rare disorder was characterized by hypercalciuria, low molecular weight (LMW) proteinuria and proximal tubular dysfunction, caused by pathoge...

    Authors: Nan Duan, Chenwei Huang, Lu Pang, Shiju Jiang, Wenshuang Yang and Haixia Li

    Citation: BMC Nephrology 2021 22:24

    Content type: Case report

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  18. Nephropathy associated metabolic disorder induces high incidence of fragility fracture in end-stage renal disease (ESRD) patients. As the risk factors and prognosis of fragility fracture in ESRD patients are u...

    Authors: Lihua Xie, Xuantao Hu, Wenzhao Li and Zhengxiao Ouyang

    Citation: BMC Nephrology 2021 22:23

    Content type: Research article

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  19. IgG4-related kidney disease (IgG4-RKD) can affect multiple organs, which was first reported as a complication or extra-organ manifestation of autoimmune pancreatitis in 2004. It is characterized by abundant Ig...

    Authors: Yili Xu, Guang Yang, Xueqiang Xu, Yaoyu Huang, Kang Liu, Tongfu Yu, Jun Qian, Xiufen Zhao, Jingfeng Zhu, Ningning Wang and Changying Xing

    Citation: BMC Nephrology 2021 22:22

    Content type: Case report

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  20. Damage to the endothelial glycocalyx is an early indicator of vascular damage and a potential marker of endothelial dysfunction. This study aimed to assess the relationship between markers of glycocalyx damage...

    Authors: Hui Liew, Matthew A. Roberts, Alun Pope and Lawrence P. McMahon

    Citation: BMC Nephrology 2021 22:21

    Content type: Research article

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  21. Although patients undergoing continuous renal replacement therapy (CRRT) due to acute kidney injury (AKI) frequently have instability in mean arterial pressure (MAP), no consensus exists on the target value of...

    Authors: Yaerim Kim, Donghwan Yun, Soie Kwon, Kyubok Jin, Seungyeup Han, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Sejoong Kim and Seung Seok Han

    Citation: BMC Nephrology 2021 22:20

    Content type: Research article

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  22. Acute kidney injury (AKI) associated with severe coronavirus disease 19 (COVID-19) is common and is a significant predictor of morbidity and mortality, especially when dialysis is required. Case reports and au...

    Authors: Katarzyna Szajek, Marie-Elisabeth Kajdi, Valerie A. Luyckx, Thomas Hans Fehr, Ariana Gaspert, Alexia Cusini, Karin Hohloch and Philipp Grosse

    Citation: BMC Nephrology 2021 22:19

    Content type: Case report

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  23. Albuminuria is an established risk marker for both cardiovascular and renal outcomes. In this study, we expected to use portable and inexpensive test strips to detect urine albumin level for risk stratificatio...

    Authors: Noppawit Aiumtrakul, Kitinan Phichedwanichskul, Surapong Saravutthikul, Kamonwan Ottasat, Kesinee Visuthitepkul, Thitinat Jaruthiti, Sarita Jinawong, Kwanchanok Chanthowong, Varot Pengsritong, Nattawinee Horadee, Chotip Jitudomtham, Torpathom Pruekprasert, Thakorn Tawatkiratipol, Tunjira Chokjutha, Panuwat Pongpripoom, Chirayu Wiwatwarapon…

    Citation: BMC Nephrology 2021 22:18

    Content type: Research article

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  24. Valid instruments for measuring physical activity at the low end of the physical activity range and producing quantitative results are required among dialysis patients who are extremely inactive. This study ai...

    Authors: Rui Huang, Haifen Zhang, Yan Yang, Nina Fang, Qian Liu, Jun Ma, Min Wang, Ling Shi and Xingjuan Tao

    Citation: BMC Nephrology 2021 22:17

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2021 22:38

  25. Hemodialysis is considered a major therapeutic method for patients with chronic kidney disease. Pruritus is a common complaint of hemodialysis patients. The 5-D pruritus scale is amongst the most common tools ...

    Authors: Amin Kordi Yoosefinejad, Fatemeh Karjalian, Marzieh Momennasab and Shahrokh Ezzatzadegan Jahromi

    Citation: BMC Nephrology 2021 22:16

    Content type: Research article

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  26. Serum and tissue-based tests using phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are established immune biomarkers for the diagnosis of primary membranous nephropa...

    Authors: Bingileki F Lwezaula, Oluwatoyin I Ameh, Udeme E Ekrikpo, Francois CJ Botha, Ugochi S Okpechi-Samuel, Nicola Wearne, Pierre Ronco, Aminu K Bello and Ikechi G. Okpechi

    Citation: BMC Nephrology 2021 22:15

    Content type: Research article

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  27. Some sea anemone toxins cause renal injuries resembling hemolytic uremic syndrome (HUS). To date, only a few cases of HUS caused by sea anemone stings have been reported. In this case report, we have described...

    Authors: A Young Kim, Kyu Hyang Cho, Seok Hui Kang, Jong Won Park, Jun Young Do and Min Kyoung Kim

    Citation: BMC Nephrology 2021 22:14

    Content type: Case report

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  28. The relationship between malnutrition-inflammation-atherosclerosis syndrome (MIAS) and self-management ability has not been previously revealed even though both play an important role in the management of peri...

    Authors: Zehui Huang, Junyan Fang, Ahui Song, Yan Tong, Hai Deng, Shan Wei, Ouyang Ji, Chun Hu, Pu Li, Chunli Zhang and Yingli Liu

    Citation: BMC Nephrology 2021 22:13

    Content type: Research article

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  29. AarF domain-containing kinase 4 (ADCK4)-associated glomerulopathy is a mitochondrial nephropathy caused by mutations in the ADCK4 gene, which disrupt coenzyme Q10 biosynthesis.

    Authors: Yan Zhang, Xiaohua Liao, Yupeng Jiang, Xin Lv, Yue Yu, Qin Dai, Liyun Ao, Lijian Tao and Zhangzhe Peng

    Citation: BMC Nephrology 2021 22:11

    Content type: Case report

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  30. Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resul...

    Authors: Carlijn G. N. Voorend, Noeleen C. Berkhout-Byrne, Yvette Meuleman, Simon P. Mooijaart, Willem Jan W. Bos and Marjolijn van Buren

    Citation: BMC Nephrology 2021 22:9

    Content type: Research article

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  31. We investigated whether implementation of the end-stage renal disease prospective payment system (ESRD PPS) was associated with changes in thrombolytic therapy use and other aspects of catheter management in h...

    Authors: Nicholas S. Roetker, Haifeng Guo, Marquita R. Decker-Palmer, Yi Peng and James B. Wetmore

    Citation: BMC Nephrology 2021 22:8

    Content type: Research article

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  32. Vascular calcification is a prominent feature in chronic kidney disease (CKD) and diabetes mellitus. A recent report suggests that angiotensin II is protective to vascular calcification. Therefore, we investig...

    Authors: Kaori Takaori, Hirotsugu Iwatani, Masafumi Yamato and Takahito Ito

    Citation: BMC Nephrology 2021 22:7

    Content type: Research article

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  33. Multiple myeloma (MM) is a plasma-cell derived hematologic malignant disease. The malignant proliferating plasma cells secrete massive monoclonal immunoglobulins which lead to various pathologic types of renal...

    Authors: Zi-hao Yong, Xiao-juan Yu, Zi-shan Lin, Fu-de Zhou, Xi-nan Cen, Su-xia Wang and Ming-hui Zhao

    Citation: BMC Nephrology 2021 22:6

    Content type: Case report

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  34. Atypical hemolytic uremic syndrome (aHUS) triggered by pregnancy is a rare disease caused by dysregulation of the alternative complement pathway that occurs in approximately 1 in 25,000 pregnancies. The 311 ph...

    Authors: Anja Gäckler, Ulf Schönermarck, Vladimir Dobronravov, Gaetano La Manna, Andrew Denker, Peng Liu, Maria Vinogradova, Sung-Soo Yoon and Manuel Praga

    Citation: BMC Nephrology 2021 22:5

    Content type: Research article

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  35. Rehospitalization is a major problem for end stage renal disease (ESRD) populations. However, researches on 30-day unexpected rehospitalzation of incident peritoneal dialysis (PD) patients were limited. This s...

    Authors: Jianbo Li, Jing Yu, Naya Huang, Hongjian Ye, Dan Wang, Yuan Peng, Xiaobo Guo, Chunyan Yi, Xiao Yang and Xueqing Yu

    Citation: BMC Nephrology 2021 22:4

    Content type: Research article

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  36. The present study aims to examine the expression of leukocyte adhesion molecules and renal metabolic factors in diabetic mouse kidneys with periodontal pathogen Pg-LPS-induced nephropathy.

    Authors: Koichiro Kajiwara, Yoshihiko Sawa, Takahiro Fujita and Sachio Tamaoki

    Citation: BMC Nephrology 2021 22:3

    Content type: Research article

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  37. Inherited cystic kidney disease is a spectrum of disorders in which clusters of renal cysts develop as the result of genetic mutation. The exact methods and pipelines for defining genetic mutations of inherite...

    Authors: Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Curie Ahn, Kyu-Beck Lee, Yeong Hoon Kim, Yunmi Kim, Seungyeup Han, Yaerim Kim, Eun hui Bae, Seong Kwon Ma, Hee Gyung Kang, Yo Han Ahn, Eujin Park, Kyungjo Jeong, Jaewon Lee…

    Citation: BMC Nephrology 2021 22:2

    Content type: Study protocol

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  38. Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare hereditary disease caused by a variety of genetic mutations. Carriers of a mutation in the responsible genes are at risk of reaching end-s...

    Authors: Tamehito Onoe, Satoshi Hara, Kazunori Yamada, Takeshi Zoshima, Ichiro Mizushima, Kiyoaki Ito, Takayasu Mori, Shoichiro Daimon, Hiroaki Muramoto, Maki Shimizu, Akira Iguchi, Akihiro Kuma, Yoshifumi Ubara, Michihiro Mitobe, Hiroaki Tsuruta, Nao Kishimoto…

    Citation: BMC Nephrology 2021 22:1

    Content type: Research article

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  39. An arteriovenous fistula (AVF) is the first choice when considering access for haemodialysis (HD). When a forearm AVF fails an upper arm AVF is a frequent subsequent dialysis access option. The latter may caus...

    Authors: Michaela Wärja, Emelie Laveborn, Michael Ott, Andreas P. Jonsson and Bernd Stegmayr

    Citation: BMC Nephrology 2020 21:544

    Content type: Case report

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  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Simon D. S. Fraser, Paul J. Roderick, Carl R. May, Natasha McIntyre, Christopher McIntyre, Richard J. Fluck, Adam Shardlow and Maarten W. Taal

    Citation: BMC Nephrology 2020 21:543

    Content type: Correction

    Published on:

    The original article was published in BMC Nephrology 2015 16:193

  41. Climate change is a significant threat to the health of the Ghanaian people. Evidence abounds in Ghana that temperatures in all the ecological zones are rising, whereas rainfall levels have been generally redu...

    Authors: Richard Kobina Dadzie Ephraim, Christopher Amey Asamoah, Albert Abaka-Yawson, Precious Kwablah Kwadzokpui and Samuel Adusei

    Citation: BMC Nephrology 2020 21:542

    Content type: Research article

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  42. Blood pressure is an important and modifiable cardiovascular risk factor. Ambulatory blood pressure monitoring (ABPM) provides valuable prognostic information in patients with chronic kidney disease (CKD), yet...

    Authors: Ruo-wei Wen, Xiao-qiu Chen, Ye Zhu, Jian-ting Ke, Yi Du, Cheng Wang and Tan-qi Lou

    Citation: BMC Nephrology 2020 21:541

    Content type: Research article

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  43. Acute kidney injury (AKI) occurs commonly in the intensive care unit (ICU). Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2), known as [TIMP-2] x [IGFB...

    Authors: Lan Jia, Xiaohua Sheng, Anna Zamperetti, Yun Xie, Valentina Corradi, Shikha Chandel, Massimo De Cal, Diego Pomarè Montin, Carlotta Caprara and Claudio Ronco

    Citation: BMC Nephrology 2020 21:540

    Content type: Research article

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  44. Intravenous iron is often used to treat iron deficiency anaemia in non-dialysis chronic kidney disease (ND-CKD), but the optimal dosing regimen remains unclear. We evaluated the impact of high- versus low-dose...

    Authors: Philip A. Kalra, Sunil Bhandari, Michael Spyridon, Rachel Davison, Sarah Lawman, Ashraf Mikhail, David Reaich, Nick Pritchard, Kieran McCafferty and Jason Moore

    Citation: BMC Nephrology 2020 21:539

    Content type: Research article

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  45. Patient awareness of CKD and primary care provider (PCP) recognition of CKD are lower than for other chronic conditions. Understanding how patients may become aware of CKD is critical to their participation in...

    Authors: Alexis F. Velazquez, Alexandra Velasquez and Delphine S. Tuot

    Citation: BMC Nephrology 2020 21:538

    Content type: Research article

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  46. Illness perceptions have been shown to predict a range of psychosocial and clinical outcomes in kidney disease; including quality of life, distress, treatment adherence and even survival in end-stage renal dis...

    Authors: Priscilla Muscat, John Weinman, Emanuel Farrugia, Liberato Camilleri and Joseph Chilcot

    Citation: BMC Nephrology 2020 21:537

    Content type: Research article

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  47. Cardiovascular disease (CVD) is the most common cause of mortality in pediatric chronic kidney disease (CKD) patients. Left ventricular (LV) hypertrophy (LVH) is associated with LV diastolic dysfunction (LVDD)...

    Authors: Jeong Yeon Kim, Yeonhee Lee, Hee Gyung Kang, Il-Soo Ha, Hae Il Cheong, Hyun Jin Choi, Kyoung Hee Han, Seong Heon Kim, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee, Young Seo Park and Heeyeon Cho

    Citation: BMC Nephrology 2020 21:533

    Content type: Research article

    Published on:

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