Articles

Employment of patients with kidney failure treated with dialysis or kidney transplantation—a systematic review and meta-analysis

Patients with kidney failure treated with dialysis or kidney transplantation experience difficulties maintaining employment due to the condition itself and the treatment. We aimed to establish the rate of empl...

Authors: Lilli Kirkeskov, Rasmus K. Carlsen, Thomas Lund and Niels Henrik Buus

Cardiovascular outcomes after simultaneous pancreas kidney transplantation compared to kidney transplantation alone: a propensity score matching analysis

Coronary heart disease due to arteriosclerosis is the leading cause of death in type 1 diabetic patients with end-stage renal disease (ESRD). The aim of this study was to evaluate the effect of simultaneous pa...

Authors: U. G. Lange, S. Rademacher, B. Zirnstein, R. Sucher, K. Semmling, P. Bobbert, A. A. Lederer, D. Buchloh, L. Seidemann, D. Seehofer, N. Jahn and H.-M. Hau

Oral sodium bicarbonate in people on haemodialysis: a randomised controlled trial

Adverse events and mortality tend to cluster around dialysis sessions, potentially due to the impact of the saw-toothed profile of uraemic toxins such as potassium, peaking pre-dialysis and rapidly dropping du...

Authors: Stella I. Kourtellidou, Damien R. Ashby and Lina R. Johansson

Mycobacteria avium-related peritonitis in a patient undergoing peritoneal dialysis: case report and review of the literature

Mycobacteria avium (M. avium) is a species of ubiquitous slowly growing nontuberculous mycobacteria. It causes opportunistic infections. However, M. avium-related peritonitis in peritoneal dialysis (PD) patients ...

Authors: Jifang Lu, Zhou Jiang, Ling Wang, Shan Mou and Hao Yan

A national cohort study on hemodialysis arteriovenous fistulas after kidney transplantation - long-term patency, use and complications

To describe the long-term hemodialysis arteriovenous fistula (AVF) patency, incidence of AVF use, incidence and nature of AVF complications and surgery in patients after kidney transplantation.

Authors: Barbara Vajdič Trampuž, Miha Arnol, Jakob Gubenšek, Rafael Ponikvar and Jadranka Buturović Ponikvar

Hyperchloremia is associated with poor renal outcome after coronary artery bypass grafting

Hyperchloremia is associated with the risks of several morbidities and mortality. However, its relationship with acute kidney injury (AKI) and end-stage renal disease (ESRD) in patients undergoing coronary art...

Authors: Jae Shin Choi, Donghwan Yun, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Ki Young Na and Seung Seok Han

A longitudinal study of cardiac structure and function using echocardiography in patients undergoing peritoneal dialysis

Peritoneal dialysis (PD) can be associated with abnormal cardiac structure and function and increased mortality risk. Therefore, in this study, we analyzed the cardiac structure and function dynamic changes us...

Authors: Yunyun Zhu, Difei Zhang, Xiaoxuan Hu, Hui Liu, Yuan Xu, Haijing Hou, Yu Peng, Ying Lu, Xusheng Liu and Fuhua Lu

Patient, family and productivity costs of end-stage renal disease in the Netherlands; exposing non-healthcare related costs

Healthcare costs related to ESRD are well-described, but broader societal costs of ESRD are less known. This study aimed to estimate patient and family costs, including informal care costs and out-of-pocket co...

Authors: Eline F. de Vries, Jeanine Los, G. Ardine de Wit and Leona Hakkaart - van Roijen

Temporal changes in cardiovascular disease and infections in dialysis across a 22-year period: a nationwide study

Cardiovascular diseases (CVD) and infections are recognized as serious complications in patients with end stage kidney disease. However, little is known about the change over time in incidence of these complic...

Authors: Kamal Preet Kaur, Mavish Safdar Chaudry, Emil Loldrup Fosbøl, Lauge Østergaard, Christian Torp-Pedersen and Niels Eske Bruun

Changes in practice patterns in Japan from before to after JSDT 2013 guidelines on hemodialysis prescriptions: results from the JDOPPS

The Japanese Society for Dialysis Therapy (JSDT) published in 2013 inaugural hemodialysis (HD) guidelines. Specific targets include 1.4 for single-pool Kt/V (spKt/V) with a minimum dose of 1.2, minimum dialysi...

Authors: Tadashi Tomo, Maria Larkina, Ayumi Shintani, Tomonari Ogawa, Bruce M. Robinson, Brian Bieber, Lisa Henn and Ronald L. Pisoni

Renal infarction associated with low dose intravenous immunoglobulin in a kidney transplant recipient with sepsis: a case report and literature review

The use of human intravenous immunoglobulin gamma (IVIG) is associated with thromboembolic events as a complication. There are few reported cases of renal infarction during IVIG use in the general population, ...

Authors: Eun Woo Choi, Jun Young Do, A. Young Kim and Seok Hui Kang

Hemophagocytic lymphohistiocytosis and thrombotic microangiopathy after parvovirus B19 infection and renal transplantation: a case report

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease characterized by hyperactivation of the immune system that causes hypercytokinemia and potentially multi organ failure. HLH can o...

Authors: C. J. Steffen, N. Koch, K. U. Eckardt, K. Amann, E. Seelow and A. Schreiber

Renal angina index predicts fluid overload in critically ill children: an observational cohort study

Fluid overload and acute kidney injury are common and associated with poor outcomes among critically ill children. The prodrome of renal angina stratifies patients by risk for severe acute kidney injury, but t...

Authors: Stephen M. Gorga, Erin F. Carlton, Joseph G. Kohne, Ryan P. Barbaro and Rajit K. Basu

Impact of AKI care bundles on kidney and patient outcomes in hospitalized patients: a systematic review and meta-analysis

A bundle of preventive measures can be taken to avoid acute kidney injury (AKI) or progression of AKI. We performed a systematic review and meta-analysis to evaluate the compliance to AKI care bundles in hospi...

Authors: Hannah A. I. Schaubroeck, Diana Vargas, Wim Vandenberghe and Eric A. J. Hoste

Is health-related quality of life associated with adequacy of hemodialysis in chronic kidney disease patients?

Monitoring Health Related Quality of Life (HRQoL) in different stages of chronic kidney disease is advised by all nephrology societies. We aimed to study the relation between quality of life and dialysis adequ...

Authors: Lamia M. Hasan, Dina A. H. Shaheen, Ghada A. H. El Kannishy, Nagy A. H. Sayed-Ahmed and Ahmed M. Abd El Wahab

Improvements in six aspects of quality of care of incident hemodialysis patients – a real-world experience

The transition from chronic kidney disease stage 5 to initiation of hemodialysis has gained increased attention in recent years as this period is one of high risk for patients with an annual mortality rate exc...

Authors: Maciej Drozdz, João Frazão, Fatima Silva, Partha Das, Werner Kleophas, Wisam Al Badr, Szymon Brzosko and Stefan H. Jacobson

Online clinical pathway for chronic kidney disease management in primary care: a retrospective cohort study

Clinical pathways aim to improve patient care. We sought to determine whether an online chronic kidney disease (CKD) clinical pathway was associated with improvements in CKD management.

Authors: Maoliosa Donald, Michelle D. Smekal, Meghan J. Elliott, Kerry McBrien, Robert G. Weaver, Braden J. Manns, Marcello Tonelli, Aminu Bello, Sharon E. Straus, Nairne Scott-Douglas, Kailash Jindal and Brenda R. Hemmelgarn

Establishment of dry chemistry based reference intervals of renal function test parameters for the adult population of Kaski District, Nepal

Reference intervals (RIs) for clinical chemistry test parameters are specific to the method of measurement and population under service. However, there has been no locally available dry chemistry based RIs for...

Authors: Goma Kathayat, Daya Ram Pokharel, Naval Kishor Yadav and Manoj Sigdel

The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study

It has been shown that individuals with obesity have a higher risk for chronic kidney disease (CKD). However, it is unclear which measure of obesity is most useful for prediction of CKD in the general populati...

Authors: Ensieh Memarian, Peter M. Nilsson, Isac Zia, Anders Christensson and Gunnar Engström

Longitudinal change in c-terminal fibroblast growth factor 23 and outcomes in patients with advanced chronic kidney disease

Fibroblast growth factor23 (FGF23) is elevated in CKD and has been associated with outcomes such as death, cardiovascular (CV) events and progression to Renal Replacement therapy (RRT). The majority of studies...

Authors: Helen V. Alderson, Rajkumar Chinnadurai, Sara T. Ibrahim, Ozgur Asar, James P. Ritchie, Rachel Middleton, Anders Larsson, Peter J. Diggle, Tobias E. Larsson and Philip A. Kalra

Conversion from mycophenolate mofetil to mizoribine in the early stages of BK polyomavirus infection could improve kidney allograft prognosis: a single-center study from China

Some studies have suggested mizoribine (MZR) could inhibit the replication of BK polyomavirus (BKPyV). The purpose of this study was to explore whether conversion from mycophenolate mofetil (MMF) to MZR in the...

Authors: Ping Li, Dongrui Cheng, Jiqiu Wen, Xuefeng Ni, Kenan Xie, Xue Li and Jinsong Chen

Circulating endothelin-1 levels are positively associated with chronic kidney disease in women but not in men: a longitudinal study in the Vara-Skövde cohort

The vasoconstricting peptide endothelin-1 (ET-1) is associated with endothelial dysfunction. The aim of this paper was to investigate whether circulating ET-1 levels predicts chronic kidney disease (CKD) in a ...

Authors: Margareta I. Hellgren, Per-Anders Jansson, Hormoz Alayar, Ulf Lindblad and Bledar Daka

Correction to: Negative effects of iodine-based contrast agent on renal function in patients with moderate reduced renal function hospitalized for COVID-19

Authors: Anna Kistner, Chen Tamm, Ann Mari Svensson, Mats O. Beckman, Fredrik Strand, Magnus Sköld and Sven Nyrén

Relationship between renal function and blood pressure dipping status in renal transplant recipients: a longitudinal study

Hypertension (HT) is associated with adverse outcomes in kidney transplant (KTX) recipients. Blunting of physiological decrease in nighttime compared to daytime blood pressure (non-dipping status) is frequent ...

Authors: David A. Jaques, Patrick Saudan, Chantal Martinez, Axel Andres, Pierre-Yves Martin, Antoinette Pechere-Bertschi and Belen Ponte

A case report of breast cancer and membranous nephropathy with positive anti phospholipase A2 receptor antibodies

Testing for antibodies against podocyte phospholipase A2 receptor-1 (PLA2R) allows clinicians to accurately identify primary membranous nephropathy (MN). Secondary MN is associated with a spectrum of pathology...

Authors: David Mathew, Sanjana Gupta and Neil Ashman

Case report: a 5-year-old with new onset nephrotic syndrome in the setting of COVID-19 infection

This is a case report of an asymptomatic SARS-CoV-2 infection associated with new-onset nephrotic syndrome in a pediatric patient. This is the third case of new-onset nephrotic syndrome in children associated ...

Authors: Kelsi M. Morgan and Peace D. Imani

Nomogram predicting the risk of three-year chronic kidney disease adverse outcomes among East Asian patients with CKD

Chronic kidney disease (CKD) is a common health challenge. There are some risk models predicting CKD adverse outcomes, but seldom focus on the Mongoloid population in East Asian. So, we developed a simple but ...

Authors: Huizhen Ye, Youyuan Chen, Peiyi Ye, Yu Zhang, Xiaoyi Liu, Guanqing Xiao, Zhe Zhang, Yaozhong Kong and Gehao Liang

Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI

The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats.

Authors: You-Zhen Feng, Xiao-Qiao Chen, Zhong-Yuan Cheng, Qi-Ting Lin, Ping-Kang Chen, Ding-Kun Si-Tu, Rui Cao, Long Qian, Baoli Heng and Xiang-Ran Cai

LAMA2 and LOXL4 are candidate FSGS genes

Focal and segmental glomerulosclerosis (FSGS) is a histologic pattern of injury that characterizes a wide spectrum of diseases. Many genetic causes have been identified in FSGS but even in families with compre...

Authors: Poornima Vijayan, Saidah Hack, Tony Yao, Mohammad Azfar Qureshi, Andrew D. Paterson, Rohan John, Bernard Davenport, Rachel Lennon, York Pei and Moumita Barua

Impact of the relationship between hemoglobin levels and renal interstitial fibrosis on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy

Progression of renal anemia has been shown to be associated with advanced renal tubulointerstitial lesions. This retrospective study investigated the impact of lower hemoglobin (Hb) levels and renal interstiti...

Authors: Miho Shimizu, Kengo Furuichi, Shinji Kitajima, Tadashi Toyama, Megumi Oshima, Hisayuki Ogura, Koichi Sato, Shiori Nakagawa, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Hitoshi Yokoyama…

Improving hospital safety for patients with chronic kidney disease: a mixed methods study

People living with chronic kidney disease (CKD) require complex medical management and may be frequently hospitalized. Patient safety incidents during hospitalization can result in serious complications which ...

Authors: Lucia New, Donna Goodridge, Joanne Kappel, Joshua Lawson, Roy Dobson, Erika Penz, Gary Groot and John Gjevre

Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort

HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8–16%; however, in HIV sub...

Authors: Verónica Valdivia-Cerda, Monserrat Alvarez-Zavala, Karina Sánchez-Reyes, Rodolfo I. Cabrera-Silva, Vida V. Ruiz-Herrera, Aldo D. Loza-Salazar, Pedro Martínez-Ayala, Juan C. Vázquez-Limón, Guillermo García-García, Jaime F. Andrade-Villanueva and Luz A. González-Hernández

LDLR gene polymorphism (rs688) affects susceptibility to cardiovascular disease in end-stage kidney disease patients

The low-density lipoprotein receptor (LDLR) plays a significant role in maintaining the cellular cholesterol homeostasis. Mutations in the LDLR gene can lead to a significant rise in plasma LDL levels that may re...

Authors: Monika Buraczynska, Jerry Jacob, Karolina Gwiazda-Tyndel and Andrzej Ksiazek

Practices and pitfalls in medication adherence in hemodialysis settings – a focus-group study of health care professionals

Medication nonadherence is common among patients with hemodialysis, leading to poorer patient outcomes. Health care professionals have an important role in assessing risk of nonadherence and intervening to sup...

Authors: Trine Mechta Nielsen, Nina Schjerning, Gudrun Kaldan, Mads Hornum, Bo Feldt-Rasmussen and Thordis Thomsen

Processing speed is affected by early impairment in kidney function in the general elder population

Chronic kidney disease, cardiovascular disease, and cognitive dysfunction are common in the elder population. There is evidence of a connection between these conditions, possibly by a shared vascular pathogene...

Authors: Tomas Månsson and Sölve Elmståhl

Transmission of SARS-CoV-2 considering shared chairs in outpatient dialysis: a real-world case-control study

SARS-CoV-2 can remain transiently viable on surfaces. We examined if use of shared chairs in outpatient hemodialysis associates with a risk for indirect patient-to-patient transmission of SARS-CoV-2.

Authors: Ravi Thadhani, Joanna Willetts, Catherine Wang, John Larkin, Hanjie Zhang, Lemuel Rivera Fuentes, Len Usvyat, Kathleen Belmonte, Yuedong Wang, Robert Kossmann, Jeffrey Hymes, Peter Kotanko and Franklin Maddux

Clinical practice guidelines standardisation of immunosuppressive and anti-infective drug regimens in UK paediatric renal transplantation: the harmonisation programme

Authors: Jan Dudley, Martin Christian, Alice Andrews, Nicola Andrews, Julie Baker, Sheila Boyle, Mairead Convery, Fiona Gamston, Martin Garcia, Shuman Haq, Shivaram Hegde, Richard Holt, Helen Jones, Shakeeb Khan, Jennifer McCaughan, David Milford…

Association of uric acid and uric acid to creatinine ratio with chronic kidney disease in hypertensive patients

Recent studies have shown that the serum uric acid/creatinine ratio (SUA/SCr) is a better predictor of chronic kidney disease (CKD) than serum uric acid (SUA) isolated. The aim of the present study was to eval...

Authors: Nathalia Rabello Silva, Camila Evangelista Torres Gonçalves, Danilo Lemes Naves Gonçalves, Rosângela Minardi Mitre Cotta and Luciana Saraiva da Silva

Comprehensive analysis of lysine crotonylation modification in patients with chronic renal failure

Post-translational modifications (PTMs) are at the heart of many cellular signaling events, which changes the function of protein. Crotonylation, one of the most important and common PTMs, plays a crucial role...

Authors: Jiahuang Huang, Donge Tang, Fengping Zheng, Huixuan Xu and Yong Dai

Person centred care provision and care planning in chronic kidney disease: which outcomes matter? A systematic review and thematic synthesis of qualitative studies

Explore priorities related to outcomes and barriers of adults with chronic kidney disease (CKD) regarding person centred care and care planning.

Authors: Ype de Jong, Esmee M. van der Willik, Jet Milders, Yvette Meuleman, Rachael L. Morton, Friedo W. Dekker and Merel van Diepen

The best solution down the line: an observational study on taurolidine- versus citrate-based lock solutions for central venous catheters in hemodialysis patients

To prevent infection and thrombosis of central venous catheters (CVCs) in hemodialysis patients, different CVC lock solutions are available. Taurolidine-based solutions and citrate in different concentrations ...

Authors: Sonja van Roeden, Mathijs van Oevelen, Alferso C. Abrahams, Friedo W. Dekker, Joris I. Rotmans and Sabine C. A. Meijvis

Does conservative kidney management offer a quantity or quality of life benefit compared to dialysis? A systematic review

Patients with stage 5 chronic kidney disease (CKD5) collaborate with their clinicians when choosing their future treatment modality. Most elderly patients with CKD5 may only have two treatment options: dialysi...

Authors: Buur Louise Engelbrecht, Madsen Jens Kristian, Eidemak Inge, Krarup Elizabeth, Lauridsen Thomas Guldager, Taasti Lena Helbo and Finderup Jeanette

The association of urine osmolality with decreased kidney function and/or albuminuria in the United States

Decreased kidney function is commonly caused by hypovolemia. When hypovolemic, the kidney reabsorbs water resulting in concentrated urine. Osmolality is a measure of urine concentration which is more objective...

Authors: Boonsong K. Kitiwan, Sarinnapha M. Vasunilashorn, Heather J. Baer, Kenneth Mukamal and Stephen P. Juraschek

Reduced serum albumin as a risk factor for poor prognosis in critically ill patients receiving renal replacement therapy

Albumin is the primary body protein, which can predict the poor prognosis of several critical diseases. However, there are a few scientific studies on the relationship between albumin and the prognosis of dial...

Authors: Lang Jing Zheng, Weiming Jiang, Lingling Pan and Jingye Pan

Efficacy of tripterygium glycosides for diabetic nephropathy: a meta-analysis of randomized controlled trials

Diabetic nephropathy (DN) is one of the most important clinical complications of diabetes mellitus (DM) and is the most common cause of end-stage renal disease. Currently, there is no highly effective medicine...

Authors: Hua-Bin Guo, Jia-Qing Peng, Xuan Wang, Ke-Kai Zhang, Guang-Zhi Zhong, Wei-Hong Chen and Gui-Xin Shi

Efficacy of rituximab in thymoma associated minimal change disease: case report

Thymomas have been associated with a broad spectrum of autoimmune diseases. Minimal change disease (MCD) is the most frequent pathological lesion reported. Pathophysiological mechanisms involved in secondary M...

Authors: Zhour El Ouafi, Clovis Mugnier, Robin Jeannet, Clément Danthu, Marion Duval, Valère Belle Mbou and Fatouma Touré

Association of elevated serum aminotransferase levels with chronic kidney disease measures: hispanic community health study/study of latinos

Previous studies have shown an association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD), but it is unclear whether the association is independent of metabolic syndrome.

Authors: Celestin Missikpode, Holly Kramer, Scott J. Cotler, Ramon Durazo-Arvizu, James P. Lash, Eric Kallwitz, Jianwen Cai, Mark H. Kuniholm, Sylvia E. Rosas, Ana C. Ricardo, Gregory A. Talavera, Leopoldo Raij, Amber Pirzada and Martha L. Daviglus

Experiences of renal healthcare practitioners during the COVID-19 pandemic: a multi-methods approach

Globally, renal healthcare practitioners provide intensive and protracted support to a highly complex multi-morbid patient population however knowledge about the impact of COVID-19 on these practitioners is ex...

Authors: Clare Mc Keaveney, Joanne Reid, Claire Carswell, Ann Bonner, Ilaria de Barbieri, William Johnston, Alexander P. Maxwell, Julien O’Riordan, Veronica Strini, Ian Walsh and Helen Noble

Timing of AKI after urgent percutaneous coronary intervention and clinical outcomes: a high-dimensional propensity score analysis

Acute kidney injury is a common complication of percutaneous coronary intervention and has been associated with an increased risk of death and progressive chronic kidney disease. However, whether the timing of...

Authors: Alan S. Go, Thida C. Tan, Rishi V. Parikh, Andrew P. Ambrosy, Leonid V. Pravoverov, Sijie Zheng and Thomas K. Leong

Renal biomarkers of acute kidney injury in response to increasing intermittent hypoxia episodes in the neonatal rat

We tested the hypotheses that: 1) early exposure to increasing episodes of clinically relevant intermittent hypoxia (IH) is detrimental to the developing kidneys; and 2) there is a critical number of daily IH ...

Authors: Anano Zangaladze, Charles L. Cai, Matthew Marcelino, Jacob V. Aranda and Kay D. Beharry