Articles

Achieved blood pressure post-acute kidney injury and risk of adverse outcomes after AKI: A prospective parallel cohort study

There has recently been considerable interest in better understanding how blood pressure should be managed after an episode of hospitalized AKI, but there are scant data regarding the associations between bloo...

Authors: Ian McCoy, Sandeep Brar, Kathleen D. Liu, Alan S. Go, Raymond K. Hsu, Vernon M. Chinchilli, Steven G. Coca, Amit X. Garg, Jonathan Himmelfarb, T. Alp Ikizler, James Kaufman, Paul L. Kimmel, Julie B. Lewis, Chirag R. Parikh, Edward D. Siew, Lorraine B. Ware…

Community- versus hospital-acquired acute kidney injury in hospitalised COVID-19 patients

Acute kidney injury (AKI) is a recognised complication of coronavirus disease 2019 (COVID-19), yet the reported incidence varies widely and the associated risk factors are poorly understood.

Authors: Jack S Bell, Benjamin D James, Saif Al-Chalabi, Lynne Sykes, Philip A Kalra and Darren Green

Primary membranous glomerulonephritis with negative serum PLA2R in haemophilia A successfully managed with rituximab – case report and review of the literature

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause a wide range of glomerular pathologies. In people with haemophilia, transfusion-associated infections with these viruses are common and defi...

Authors: Nicholas Meyer, Wendy Cooper, Paul Kirwan, Roger Garsia, Scott Dunkley and David M. Gracey

Eculizumab in gemcitabine-induced thrombotic microangiopathy: experience of the French thrombotic microangiopathies reference centre

Gemcitabine is a broadly prescribed chemotherapy, the use of which can be limited by renal adverse events, including thrombotic microangiopathy (TMA).

Authors: Maximilien Grall, Florence Daviet, Noémie Jourde Chiche, François Provot, Claire Presne, Jean-Philippe Coindre, Claire Pouteil-Noble, Alexandre Karras, Dominique Guerrot, Arnaud François, Ygal Benhamou, Agnès Veyradier, Véronique Frémeaux-Bacchi, Paul Coppo and Steven Grangé

Can remote ischemic preconditioning counteract the renal functional deterioration attributable to partial nephrectomy under warm ischemia? Results of an animal study

To investigate if remote ischemic preconditioning (RIPC) can offer any renoprotective value by counteracting the deleterious effect of partial nephrectomy (PN) under warm ischemia on renal function.

Authors: Tuna Till Mut, Ömer Acar, Ayse Armutlu, Said Incir, Annemarie Uhlig, Lale A. Ertuglu, Melis Özel, Ali Cihan Taskin, Dilek Ertoy Baydar, Mehmet Kanbay and Tarık Esen

Renal recipients’ knowledge and self-efficacy during first year after implementing an evidence based educational intervention as routine care at the transplantation clinic

Following an implementation plan based on dynamic dialogue between researchers and clinicians, this study implemented an evidence-based patient education program (tested in an RCT) into routine care at a clini...

Authors: Kristin Hjorthaug Urstad, Astrid Klopstad Wahl, Torbjørn Moum, Eivind Engebretsen and Marit Helen Andersen

Proton-pump inhibitor vs. H2-receptor blocker use and overall risk of CKD progression

The relationship between proton-pump inhibitor (PPI) use and chronic kidney disease (CKD) progression remains controversial. Specifically, there is a lack of data evaluating renal outcomes in established CKD p...

Authors: Liza Cholin, Tarek Ashour, Ali Mehdi, Jonathan J. Taliercio, Remy Daou, Susana Arrigain, Jesse D. Schold, George Thomas, Joseph Nally, Nazih L. Nakhoul and Georges N. Nakhoul

What are the information needs and concerns of individuals with Polycystic Kidney Disease? Results of an online survey using Facebook and social listening analysis

Polycystic Kidney Disease (PKD) is a hereditary disorder that has no cure and can result in end stage kidney failure. Searching for health information online and via social media is a common phenomenon in many...

Authors: Tiffany Ma and Kelly Lambert

An anastomosing hemangioma mimicking a renal cell carcinoma in a kidney transplant recipient: a case report

Although anastomosing hemangiomas are very rare and benign vascular neoplasms, these tumors are more common among patients with end-stage kidney disease. Incidental finding of these tumors in the kidney or adr...

Authors: Chang Seong Kim, Soo Jin Na Choi, Sung-Sun Kim, Sang Heon Suh, Eun Hui Bae, Seong Kwon Ma and Soo Wan Kim

Atypical histological abnormalities in an adult patient with nephronophthisis harboring NPHP1 deletion: a case report

Nephronophthisis (NPHP) is a chronic tubular interstitial disorder that exhibits an autosomal recessive genetic form and causes progressive renal failure in children. Patients with NPHP rarely show urinary abn...

Authors: Maiko Akira, Hitoshi Suzuki, Arisa Ikeda, Masako Iwasaki, Daisuke Honda, Hisatsugu Takahara, Hisaki Rinno, Shigeki Tomita and Yusuke Suzuki

Caffeine-induced hypokalemia: a case report

With an increase in the global popularity of coffee, caffeine is one of the most consumed ingredients of modern times. However, the consumption of massive amounts of caffeine can lead to severe hypokalemia.

Authors: Min Jee Han, Su-Hyun Kim, Jung-ho Shin and Jin Ho Hwang

Health literacy level in a various nephrology population from Québec: predialysis clinic, in-centre hemodialysis and home dialysis; a transversal monocentric observational study

Health literacy refers to the ability of individuals to gain access to, use, and understand health information and services in order to maintain a good health. It is especially important in nephrology due to t...

Authors: Annabel Boyer, Yannick Begin, Julie Dupont, Mathieu Rousseau-Gagnon, Nicolas Fernandez, Maryam Demian, David Simonyan, Mohsen Agharazii and Fabrice Mac-Way

Simultaneous heart-kidney transplantation results in respectable long-term outcome but a high rate of early kidney graft loss in high-risk recipients – a European single center analysis

In spite of renal graft shortage and increasing waiting times for transplant candidates, simultaneous heart and kidney transplantation (HKTx) is an increasingly performed procedure established for patients wit...

Authors: Oliver Beetz, Juliane Thies, Clara A. Weigle, Fabio Ius, Michael Winkler, Christoph Bara, Nicolas Richter, Jürgen Klempnauer, Gregor Warnecke, Axel Haverich, Murat Avsar and Gerrit Grannas

Differences in the clinical presentation, management, and in-hospital outcomes of acute aortic dissection in patients with and without end-stage renal disease

Few studies have evaluated the clinical presentation, management, and outcomes of patients with end-stage renal disease (ESRD) presenting with acute aortic dissection (AAD) in real-world clinical practice. Thu...

Authors: Jiahe Xie, Shan Zeng, Long Xie, Rongming Ding, Jing Hu, Hong Zeng, Weiling Lu, Yuhua Hu, Qingrui Li, Gaojun Zhong, Shiju Zhou, Ziyou Liu, Yulin Liao, Yiming Zhong and Dongming Xie

Cannulation technique and complications in arteriovenous fistulas: a Swedish Renal Registry-based cohort study

The four cannulation techniques, rope ladder (RL), area puncture (AP), buttonhole with blunt needles (BHb), and buttonhole with sharp needles (BHs), affects the arteriovenous fistula (AVF) in different ways. T...

Authors: Karin Staaf, Anders Fernström and Fredrik Uhlin

Correction to: Hemolytic uremic syndrome caused by sea anemone sting: a case report

Authors: A. Young Kim, Kyu Hyang Cho, Seok Hui Kang, Jong Won Park, Jun Young Do and Min Kyoung Kim

The LIFT trial: study protocol for a double-blind, randomised, placebo-controlled trial of K⁺-binder Lokelma for maximisation of RAAS inhibition in CKD patients with heart failure

CKD is common in heart failure (HF) and associated with morbidity and mortality, yet life-prolonging medications such as renin-angiotensin-aldosterone inhibitors (RAASi) are underused due to risk of hyperkalae...

Authors: Daniel Murphy, Irina Chis Ster, Juan-Carlos Kaski, Lisa Anderson and Debasish Banerjee

Recurrent membranous nephropathy with a possible alteration in the etiology: a case report

Phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major pathogenic antigens for membranous nephropathy (MN). It has been reported that THSD7A-associated M...

Authors: Ayumi Matsumoto, Isao Matsui, Keiji Mano, Hitoshi Mizuno, Yusuke Katsuma, Seiichi Yasuda, Karin Shimada, Kazunori Inoue, Takashi Oki, Tadashi Hanai, Keiko Kojima, Tetsuya Kaneko and Yoshitaka Isaka

Complement activation and blockade in massive post-partum haemorrhage, thrombotic microangiopathy and acute kidney injury: a case report

Thrombotic microangiopathy (TMA)-mediated acute kidney injury (AKI) following massive haemorrhage is a rare but severe complication of the post-partum period. It is associated with a poor renal prognosis and a...

Authors: G. Guzzo, S. Kissling, G. Pantaleo, M. Pascual, S. Sadallah and D. Teta

Renal transplantation after recovery from COVID-19 - a case report with implications for transplant programs in the face of the ongoing corona-pandemic

The ongoing coronavirus pandemic has major impacts on both patients and healthcare systems worldwide, thus creating new realities. Patients on maintenance dialysis listed for renal transplantation are a vulner...

Authors: Katharina Tuschen, Johanna Anders, Amin Elfanish, Verena Schildgen, Oliver Schildgen, Jan Ulrich Becker and Alexander Weidemann

Hepatic cysteine sulphinic acid decarboxylase depletion and defective taurine metabolism in a rat partial nephrectomy model of chronic kidney disease

Taurine depletion occurs in patients with end-stage chronic kidney disease (CKD). In contrast, in the absence of CKD, plasma taurine is reported to increase following dietary L-glutamine supplementation. This ...

Authors: Nima Abbasian, Maryam Ghaderi-Najafabadi, Emma Watson, Jeremy Brown, Li Yu si, Debbie Bursnall, Izabella Pawluczyk, Anne-Marie Seymour and Alan Bevington

Severe restless legs syndrome in a family with Alport syndrome

Restless legs syndrome (RLS) is a common sleep-related movement disorder characterized by an urge to move the legs during inactivity, especially at evening-night. RLS is highly prevalent in patients with kidne...

Authors: Davide Sparasci, Andrea Rossinelli, Raffaele Ferri, Pietro Cippà, Andrea Rinaldi and Mauro Manconi

Clinicopathological and prognostic study of IgA-dominant postinfectious glomerulonephritis

The clinicopathological and prognostic features of IgA-dominant postinfectious glomerulonephritis and its difference from the primary IgA nephropathy remains to be investigated.

Authors: Ziyuan Huang, Bo Chen, Ying Zhou, Yan Liang, Wenxian Qiu, Yinqiu Lv, Xiaokai Ding, Ji Zhang and Chaosheng Chen

Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study

Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not we...

Authors: Miyeun Han, Hyunsuk Kim, Hyo Jin Kim, Eunjeong Kang, Yong-Soo Kim, Kyu Hun Choi, Soo Wan Kim, Curie Ahn and Kook-Hwan Oh

Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study

Poor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD). Handgrip strength (HGS) is an important index for physical function in the g...

Authors: Yang Cheng, Min Liu, Yu Liu, Haifeng Xu, Xiaotian Chen, Hui Zheng, Xiaojun Wu, Zhixiang Shen and Chong Shen

Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

Diabetic nephropathy (DN) is the major complication of diabetes mellitus, and leading cause of end-stage renal disease. The underlying molecular mechanism of DN is not yet completely clear. The aim of this stu...

Authors: Alieh Gholaminejad, Mohammad Fathalipour and Amir Roointan

Regional citrate anticoagulation “non-shock” protocol with pre-calculated flow settings for patients with at least 6 L/hour liver citrate clearance

Regional citrate anticoagulation (RCA) for the prevention of clotting of the extracorporeal blood circuit during continuous kidney replacement therapy (CKRT) has been employed in limited fashion because of the...

Authors: Lenar Yessayan, Ryann Sohaney, Vidhit Puri, Benjamin Wagner, Amy Riddle, Sharon Dickinson, Lena Napolitano, Michael Heung, David Humes and Balazs Szamosfalvi

Implementation and effectiveness of an intensive education program on phosphate control among hemodialysis patients: a non-randomized, single-arm, single-center trial

Hyperphosphatemia is a common complication in patients on maintenance hemodialysis. Patients’ adherence to phosphorus control can be improved by consistent education. However, few studies have focused on the m...

Authors: Jinmei Yin, Jun Yin, Rongli Lian, Peiqiu Li and Jing Zheng

Extended infusion of rituximab combined with steroids is effective in inducing remission and reducing relapse in adult minimal change disease

Minimal change disease is a common cause of nephrotic syndrome in adults. Higher relapse rate put patients at risk of steroids toxicity due to long-term exposure. Rituximab has been suggested to maintain long ...

Authors: Diankun Liu, Zhanmei Zhou, Mengyi Wang, Sheng Nie, Jun Li, Bianxiang Hu, Wenjuan He, Guobao Wang and Jun Ai

Eosinophilic interstitial nephritis and cardiac insufficiency in Kimura’s disease: a case report

Kimura’s disease (KD) is a rare chronic inflammatory disease and the etiology remains uncharacterized. The typical manifestations are painless lymph node or subcutaneous masses. There is currently no report of pr...

Authors: Li Xiang, Hua Zhou, Hua Liu, Dachuan Zhang, Min Li, Min Yang and Yan Yang

Association between potassium supplementation and the occurrence of acute kidney injury in patients with hypokalemia administered liposomal amphotericin B: a nationwide observational study

Hypokalemia and acute kidney injury (AKI) occur in patients administered liposomal amphotericin B (L-AMB), a wide-spectrum anti-fungicidal drug. However, the association between potassium supplementation and t...

Authors: Yuki Ota, Yoko Obata, Takahiro Takazono, Masato Tashiro, Tomotaro Wakamura, Akinori Takahashi, Yui Shiozawa, Taiga Miyazaki, Tomoya Nishino and Koichi Izumikawa

Cigarette smoking may accelerate the progression of IgA nephropathy

Whether cigarette smoking is associated with the progression of immunoglobulin A nephropathy (IgAN) remains uncertain; therefore, we aimed to evaluate the effect of cigarette smoking on the prognosis of IgAN.

Authors: Siqing Wang, Aiya Qin, Gaiqin Pei, Zheng Jiang, Lingqiu Dong, Jiaxing Tan, Li Tan, Yi Tang and Wei Qin

Incidence and risk predictors of acute kidney injury among HIV-positive patients presenting with sepsis in a low resource setting

Acute kidney injury (AKI) is a frequently encountered clinical condition in critically ill patients and is associated with increased morbidity and mortality. In our resource-limited setting (RLS), the most com...

Authors: Davis Kimweri, Julian Ategeka, Faustine Ceasor, Winnie Muyindike, Edwin Nuwagira and Rose Muhindo

Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience

Diffusion-weighted (DW) and blood oxygen level-dependent (BOLD) magnetic resonance imaging are classical sequences of functional MR, but the exploration in non-transplanted kidney disease is limited. Objects: ...

Authors: Tao Su, Xuedong Yang, Rui Wang, Li Yang and Xiaoying Wang

Effect of Oral carnosine supplementation on urinary TGF-β in diabetic nephropathy: a randomized controlled trial

Activation of the transforming growth factor beta (TGF-β) pathway is a significant contributor to the pathogenesis of diabetic nephropathy. Carnosine is a dipeptide that can inhibit TGF-β synthesis. We tested ...

Authors: Narongrit Siriwattanasit, Bancha Satirapoj and Ouppatham Supasyndh

Trends in incidence and long-term prognosis of acute kidney injury following coronary angiography in Chinese cohort with 11,943 patients from 2013 to 2017: an observational study

Contrast-associated acute kidney injury (CA-AKI) is a common complication with poor prognosis after coronary angiography (CAG). With the prevention methods widely being implemented, the temporal trends of inci...

Authors: Jin Liu, Qiang Li, Disheng Lai, Guoqin Chen, Bo Wang, Liwei Liu, Haozhang Huang, Zhubin Lun, Ming Ying, Guanzhong Chen, Zhidong Huang, Danyuan Xu, Liangguang Meng, Xiaoming Yan, Weiyan Qiu, Ning Tan…

Impact of rural versus urban setting on kidney markers: a cross-sectional study in South-Kivu, DRCongo

Most studies of chronic kidney disease (CKD) in Sub-Saharan Africa (SSA) have been conducted in urban settings. They relied on GFR estimated from serum creatinine alone and on the inexpensive, convenient urina...

Authors: Mannix Imani Masimango, Michel P. Hermans, Espoir Bwenge Malembaka, Pierre Wallemacq, Ernest Kiswaya Sumaili, Catherine Fillée, William D’Hoore, Cheryl A. Winkler, Sophie Limou and Michel Jadoul

Development of a preliminary conceptual model of the patient experience of chronic kidney disease: a targeted literature review and analysis

Patient-reported outcome (PRO) instruments should capture the experiences of disease and treatment that patients consider most important in order to inform patient-centred care and product development. The aim...

Authors: Jennifer E. Flythe, Niklas Karlsson, Anna Sundgren, Paul Cordero, Amanda Grandinetti, Henry Cremisi and Anna Rydén

Risks associated with continuation of potentially inappropriate antihypertensive medications in older adults receiving hemodialysis

After dialysis initiation, older adults may experience orthostatic or post-dialysis hypotension. Some orthostasis-causing antihypertensives (i.e., central alpha agonists and alpha blockers), are considered pot...

Authors: Rasheeda K. Hall, Sarah Morton, Jonathan Wilson, Patti L. Ephraim, L. Ebony Boulware, Wendy L. St. Peter, Cathleen Colón-Emeric, Jane Pendergast and Julia J. Scialla

Deep learning-based framework for the distinction of membranous nephropathy: a new approach through hyperspectral imagery

Common subtypes seen in Chinese patients with membranous nephropathy (MN) include idiopathic membranous nephropathy (IMN) and hepatitis B virus-related membranous nephropathy (HBV-MN). However, the morphologic...

Authors: Tianqi Tu, Xueling Wei, Yue Yang, Nianrong Zhang, Wei Li, Xiaowen Tu and Wenge Li

Positive renal familial history in IgA nephropathy is associated with worse renal outcomes: a single-center longitudinal study

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Although most IgAN cases are sporadic, few show a familial aggregation. However, the prevalence and prognosis of IgAN individuals...

Authors: Yoshinori Sato, Hiroyasu Tsukaguchi, Koichiro Higasa, Naoto Kawata, Kiyoko Inui, Tran Nguyen Truc Linh, Tran Thuy Huong Quynh, Inoue Yoshihiko, Fumihiko Koiwa and Ashio Yoshimura

Prevalence and determinants of chronic kidney disease in women with hypertensive disorders in pregnancy in Nigeria: a cohort study

Worldwide, hypertensive disorders in pregnancy (HDPs) complicate between 5 and 10% of pregnancies. Sub-Saharan Africa (SSA) is disproportionately affected by a high burden of HDPs and chronic kidney disease (C...

Authors: Salisu M. Ishaku, Timothy Olusegun Olanrewaju, Joyce L. Browne, Kerstin Klipstein-Grobusch, Gbenga A. Kayode, Arie Franx, Diederick E. Grobbee and Charlotte E. Warren

The potential renal toxicity of silver nanoparticles after repeated oral exposure and its underlying mechanisms

Silver nanoparticles (AgNPs) can accumulate in various organs after oral exposure. The main objective of the current study is to evaluate the renal toxicity induced by AgNPs after repeated oral exposure and to...

Authors: Hamed Nosrati, Manijeh Hamzepoor, Maryam Sohrabi, Massoud Saidijam, Mohammad Javad Assari, Nooshin Shabab, Zahra Gholami Mahmoudian and Zohreh Alizadeh

Association between physical activity and mortality in end-stage kidney disease: a systematic review of observational studies

End-stage Kidney Disease patients have a high mortality and hospitalization risk. The association of these outcomes with physical activity is described in the general population and in other chronic diseases. ...

Authors: Pedro Martins, Elisa A. Marques, Diogo V. Leal, Aníbal Ferreira, Kenneth R Wilund and João L. Viana

Routine immunohistochemistry study for polyomavirus BK nephropathy in transplanted kidney biopsies, is it recommended?

Early diagnosis and treatment of Polyomavirus BK Nephropathy (PVBKN) is a challenging issue in the management of patients with kidney transplantation. Currently, histopathologic diagnosis is the gold standard ...

Authors: Fatemeh Nili, Maliheh Mohammadhoseini, Seyed Mohammadreza Khatami, Golnar Seirafi and Majidreza Haghzare

Association between dialysate sodium concentration and interdialytic weight gain in patients undergoing twice weekly haemodialysis

Chronic kidney disease is highly prevalent across the globe with more than 2 million people worldwide requiring renal replacement therapy. Interdialytic weight gain is the change in body weight between two ses...

Authors: Soraiya Manji, Jasmit Shah, Ahmed Twahir and Ahmed Sokwala

Chronic anticoagulation is not associated with a reduced risk of acute kidney injury in hospitalised Covid-19 patients

Coronavirus-19 (COVID-19) has been declared a global pandemic by the World Health Organisation. Severe disease typically presents with respiratory failure but Acute Kidney Injury (AKI) and a hypercoagulable st...

Authors: Kathrine Parker, Patrick Hamilton, Prasanna Hanumapura, Laveena Castelino, Michelle Murphy, Rachael Challiner, Jecko Thachil and Leonard Ebah

Diabetic kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study

Diabetic kidney disease (DKD) is a major long-term complication of diabetes mellitus (DM). Given the paucity of data on DKD in Jordan, we aimed to evaluate the prevalence, characteristics and correlates of DKD...

Authors: Randa I. Farah, Mohammed Q. Al-Sabbagh, Munther S. Momani, Asma Albtoosh, Majd Arabiat, Ahmad M. Abdulraheem, Husam Aljabiri and Mohammad Abufaraj

Von Willebrand factor, ADAMTS13 and mortality in dialysis patients

Von Willebrand Factor (VWF) multimers are cleaved into smaller and less coagulant forms by the metalloprotease ADAMTS13. The aim of this study was to investigate the association between VWF and ADAMTS13 and mo...

Authors: Gurbey Ocak, Mark Roest, Marianne C. Verhaar, Maarten B. Rookmaaker, Peter J. Blankestijn, Willem Jan W. Bos, Rob Fijnheer, Nathalie C. Péquériaux and Friedo W. Dekker

Effect of increased blood flow rate on renal anemia and hepcidin concentration in hemodialysis patients

Increasing the blood flow rate (BFR) is a useful method for increasing Kt/V and the clearance for low molecular solutes. Hemodialysis patients are often anemic due to hypoerythropoiesis and their chronic infla...

Authors: Masateru Yamamoto, Tomio Matsumoto, Hiromitsu Ohmori, Masahiko Takemoto, Masanobu Ikeda, Ryo Sumimoto, Tsuyoshi Kobayashi, Akihiko Kato and Hideki Ohdan