Primary Outcome Measures | |
---|---|
Arterial Stiffness | – Aortic Pulse Wave Velocity (PWV) |
Oxidative Stress | – Plasma isoprostanes |
Inflammation | – Plasma pentraxin 3 |
Secondary Outcome Measures | |
Vascular Structure | – Carotid artery Intimal Medial Thickness (CIMT) |
Vascular Function | – Brachial Artery Reactivity (BAR) |
Myocardial Structure | - Left Ventricular Mass (LVmass) |
- Left Ventricular Mass Index (LVMI) | |
- Left Atrial Volume | |
- Left Ventricular Geometry | |
Myocardial Function | - Ejection Fraction (EF) |
- Early diastolic flow deceleration time (DT) | |
- Isovolumic relaxation time (IVRT) | |
- Ratio of mitral E and lateral E' (E/E') | |
- Left ventricular afterload (central pulse pressure, central systolic pressure, augmented pressure) | |
Arterial Stiffness | - Augmentation Index (AIx) |
- Pulse pressure amplification | |
Oxidative Stress | – Plasma protein carbonyls |
Antioxidant status | - Plasma total antioxidant capacity |
- Plasma antioxidant enzyme activities | |
Inflammation | – C reactive protein, IL-6, IL-8, IL-10 and TNF-alpha |
Additional blood measures | - Full blood profile, electrolytes, liver function |
- Lipid profile | |
Self reported health | – SF 36 |
Physical Activity | – Items from the Active Australia questionnaire |
Nutrition | – Four day diet diary |
Adverse events |