Table 2 Effect of ibuprofen on urine volume, urinary excretion of prostaglandin E2 (U-PGE2), aquaporin 2 (U-AQP2), urinary epithelial sodium channel (U-ENaCβ ), cyclic AMP (U-C-AMP), free water clearance (C H2O), serum osmolality (s-Osm) and plasma arginine vasopressin (P-AVP) during 24 hours fasting and 2½ hours period immediately after 24 hours fasting in a randomized placebo-controlled, cross over study in 17 healthy subjects
24 hours fasting urine collection | 2½ hours urine collection immediately after 24 hours fasting | |||||
|---|---|---|---|---|---|---|
Ibuprofen | Placebo | P | Ibuprofen | Placebo | P | |
Urine volume (ml) | 2533 (718) | 2784 (770) | NS | 2.75 (1.39) | 3.30 (1.56) | NS |
U-PGE2 (pg/min) | 270.91 (95.4) | 540.97 (365.1) | 0.027 | 282 (111) | 504 (307) | 0.02 |
U-AQP-2 (ng/min) | 1.21 (0.30) | 1.48 (0.27) | 0.00016 | 3.42 (2.07) | 4.92 (3.09) | NS |
U-AQP-2/U-Crea (ng/μmol) | 128.9 (21.5) | 158.0 (30.2) | 0.00002 | 0.29 (0.17) | 0.40 (0.18) | 0.024 |
U-ENaCβ/U-Crea (pg/μmol) | 38.7 (13) | 14.3 (3) | 0.0000002 | 40.1 (11) | 12.9 (4) | 0.000000002 |
U-c-AMP (pmol/min) | 5737 (2080) | 6381 (3041) | NS | 10909 (7061) | 13762 (9571) | NS |
CH2O (ml/min) | 0.029 (0.47) | -0.047 (0.36) | NS | 1.30 (1.40) | 1.85 (1.29) | NS |
Total Na+ excretion (mmol/24 hour) | 95 (44) | 152 (33) | 0.00001 | x | x | x |
FENa | 0.46(0.16) | 0.71 (0.20) | 0.000006 | |||
S-Osm (mosm/kg H2O) | x | x | x | 283 (2.6) | 284 (4.1) | NS |
P-AVP (pmol/l) | x | x | x | 0.86 (0.21) | 0.78 (0.20) | NS |