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Table 2 Effect of ibuprofen on urine volume, urinary excretion of prostaglandin E2 (U-PGE2), aquaporin 2 (U-AQP2), urinary epithelial sodium channel (U-ENaCβ ), cyclic AMP (U-C-AMP), free water clearance (C H2O), serum osmolality (s-Osm) and plasma arginine vasopressin (P-AVP) during 24 hours fasting and 2½ hours period immediately after 24 hours fasting in a randomized placebo-controlled, cross over study in 17 healthy subjects

From: Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels

  24 hours fasting urine collection 2½ hours urine collection immediately after 24 hours fasting
  Ibuprofen Placebo P Ibuprofen Placebo P
Urine volume (ml) 2533 (718) 2784 (770) NS 2.75 (1.39) 3.30 (1.56) NS
U-PGE2 (pg/min) 270.91 (95.4) 540.97 (365.1) 0.027 282 (111) 504 (307) 0.02
U-AQP-2 (ng/min) 1.21 (0.30) 1.48 (0.27) 0.00016 3.42 (2.07) 4.92 (3.09) NS
U-AQP-2/U-Crea (ng/μmol) 128.9 (21.5) 158.0 (30.2) 0.00002 0.29 (0.17) 0.40 (0.18) 0.024
U-ENaCβ/U-Crea (pg/μmol) 38.7 (13) 14.3 (3) 0.0000002 40.1 (11) 12.9 (4) 0.000000002
U-c-AMP (pmol/min) 5737 (2080) 6381 (3041) NS 10909 (7061) 13762 (9571) NS
CH2O (ml/min) 0.029 (0.47) -0.047 (0.36) NS 1.30 (1.40) 1.85 (1.29) NS
Total Na+ excretion (mmol/24 hour) 95 (44) 152 (33) 0.00001 x x x
FENa 0.46(0.16) 0.71 (0.20) 0.000006    
S-Osm (mosm/kg H2O) x x x 283 (2.6) 284 (4.1) NS
P-AVP (pmol/l) x x x 0.86 (0.21) 0.78 (0.20) NS
  1. Values are means and (SD). A paired t-test was used for comparison of means.