Figure 1

Haemoglobin course; simulation A (before CERA's marketing). Hb as a function of the weeks elapsed since the start of the simulation for the 6 combinations of half-lives and administration intervals (half-life in h: 24, 48 and 138; administration interval, weekly (W) or monthly (M); 24W solid line with black triangles, 48W solid line with black squares, 138W solid line with black diamonds, 24M dotted line with white triangles, 48M dotted line with white squares, 138M dotted line with white diamonds). The randomly-assigned bleeding phase between the two equilibration exercises is not represented; the second equilibration phase is synchronised. N = 25.