Table 6 Oxidative Stress Changes with Conversion to NHD

MDA (MicroM)

   Baseline

16.13+/-3.39

18.1+/-3.74

3.3 (-3.8-27.6)

   3 Months

16.50+/-3.19

16.24+/-2.51

-0.66(-8.70-12.41)

   6 Months

16.33+/-2.88

16.4+/-2.94

-0.22 (-6.29-5.86)

   P value

0.43, 0.71

0.015, 0.018

0.01, 0.005

RBC CAT (U/mgHb)

   Baseline

2.97+/-0.86

3.04+/-0.91

2.7+/-12.5

   3 Months

3.05+/-0.85

3.21+/-0.82

6.42+/-9.64

   6 Months

3.18+/-0.87

3.32+/-0.83

5.47+/-10.80

   P Value

0.18, 0.02

0.007, 0.002

0.25, 0.40

RBC GPX (U/gHb)

   Baseline

97.2 (40.1-113.4)

99.5 (41.3-112.0)

1.53+/-7.16

   3 Months

83.4 (37.9-104.7)

81.1 (37.9-108.6)

3.78+/-10.4

   6 Months

70.4 (37.2-95.0)

69.4 (36.0-92.9)

-0.10+/-11.3

   P Value

0.0001, 0.0003

0.002, 0.0001

0.37, 0.53

Plasma GPX (U/mL)

   Baseline

0.030+/-0.008

0.034+/-0.011

12.8+/-11.1

   3 Months

0.032+/-0.009

0.035+/-0.011

6.9+/-11.8

   6 Months

0.031+/-0.01

0.034+/-0.012

8.3+/-11.6

   P Value

0.04, 0.35

0.79, 0.86

0.02, 0.13

RBC SOD (U/mgHb)

   Baseline

5.75+/-1.70

6.11+/-1.61

5.69+/-20.83

   3 Months

6.32+/-2.30

6.02+/-1.58

-3.41+/-18.0

   6 Months

5.87+/-1.63

5.72+/-1.76

4.00+/-30.74

   P Value

0.29, 1.0

0.58, 0.33

0.08, 0.29

TAS

   Baseline

2.39+/-0.13

2.30+/-0.16

-4.06+/-4.47

   3 Months

2.41+/-0.12

2.30+/-0.12

-4.69+/-2.89

   6 Months

2.38+/-0.12

2.27+/-0.12

-4.55+/-3.21

   P Value

0.54, 0.50

0.95, 0.33

0.64, 0.64