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Table 6 Oxidative Stress Changes with Conversion to NHD

From: Cardiac and vascular structure and function parameters do not improve with alternate nightly home hemodialysis: An interventional cohort study

Variable Pre dialysis Post Dialysis % Change with Dialysis
MDA (MicroM)    
   Baseline 16.13+/-3.39 18.1+/-3.74 3.3 (-3.8-27.6)
   3 Months 16.50+/-3.19 16.24+/-2.51 -0.66(-8.70-12.41)
   6 Months 16.33+/-2.88 16.4+/-2.94 -0.22 (-6.29-5.86)
   P value 0.43, 0.71 0.015, 0.018 0.01, 0.005
RBC CAT (U/mgHb)    
   Baseline 2.97+/-0.86 3.04+/-0.91 2.7+/-12.5
   3 Months 3.05+/-0.85 3.21+/-0.82 6.42+/-9.64
   6 Months 3.18+/-0.87 3.32+/-0.83 5.47+/-10.80
   P Value 0.18, 0.02 0.007, 0.002 0.25, 0.40
RBC GPX (U/gHb)    
   Baseline 97.2 (40.1-113.4) 99.5 (41.3-112.0) 1.53+/-7.16
   3 Months 83.4 (37.9-104.7) 81.1 (37.9-108.6) 3.78+/-10.4
   6 Months 70.4 (37.2-95.0) 69.4 (36.0-92.9) -0.10+/-11.3
   P Value 0.0001, 0.0003 0.002, 0.0001 0.37, 0.53
Plasma GPX (U/mL)    
   Baseline 0.030+/-0.008 0.034+/-0.011 12.8+/-11.1
   3 Months 0.032+/-0.009 0.035+/-0.011 6.9+/-11.8
   6 Months 0.031+/-0.01 0.034+/-0.012 8.3+/-11.6
   P Value 0.04, 0.35 0.79, 0.86 0.02, 0.13
RBC SOD (U/mgHb)    
   Baseline 5.75+/-1.70 6.11+/-1.61 5.69+/-20.83
   3 Months 6.32+/-2.30 6.02+/-1.58 -3.41+/-18.0
   6 Months 5.87+/-1.63 5.72+/-1.76 4.00+/-30.74
   P Value 0.29, 1.0 0.58, 0.33 0.08, 0.29
TAS    
   Baseline 2.39+/-0.13 2.30+/-0.16 -4.06+/-4.47
   3 Months 2.41+/-0.12 2.30+/-0.12 -4.69+/-2.89
   6 Months 2.38+/-0.12 2.27+/-0.12 -4.55+/-3.21
   P Value 0.54, 0.50 0.95, 0.33 0.64, 0.64
  1. MDA = Plasma malonyldialdehyde; RBC = Red blood cell; CAT = Catalase; GPX = Glutathione peroxidase; SOD = Superoxide dismutase; TAS = Total antioxidant status