Table 1 Histological severity of IgAN (Japanese Clinical Guidelines )
Mesangial cell proliferation and increased matrix | Glomerulosclerosis, crescent formation or adhesion to Bowman's capsule | Interstitium, renal tubuli or blood vessels | |
|---|---|---|---|
Good prognosis | Slight | Absent | Prominent changes are not seen |
Relatively good prognosis | Slight | < 10% of all biopsied glomeruli | Prominent changes are not seen |
Relatively poor prognosis | Moderate, diffuse | 10-30% of all biopsied glomeruli | Cellular infiltration is slight in the interstitium except around some sclerosed glomeruli. Tubular atrophy is slight, and mild vascular sclerosis. |
Poor prognosis | Severe, diffuse | > 30% of all biopsied glomeruli | Interstitial cellular infiltration and tubular atrophy, as well as fibrosis are seen. Hyperplasia or degeneration may be seen in some intrarenal arteriolar walls. |