Effect of T-5224 on ICAM-1 mRNA expression in injured kidney. Bars represent the relative ratio of ICAM-1 mRNA to the control group. T-5224 significantly inhibited LPS-induced ICAM-1 mRNA expression in the kidney (4.2 ± 1.4 vs. 8.2 ± 1.4) (n = 4–6 per group). **P < 0.01 vs. control group. ##P < 0.01 vs. LPS group.