Table 1 Clinical profiles of CKD patients
| Â | Â | CKD stages | Â | ||||
|---|---|---|---|---|---|---|---|
| Â | All | 1 | 2 | 3 | 4 | 5 | p value |
Clinical and laboratory characteristics | Â | Â | Â | Â | Â | Â | Â |
Patients, n (M/F) | 131 (71/60) | 18 (6/12) | 27 (17/10) | 29 (15/14) | 18 (11/7) | 39 (22/17) | p = 0.348 |
Age (years) | 56 ± 18 | 36 ± 16 | 53 ± 18** | 55 ± 16** | 68 ± 16** | 64 ± 15** | p < 0.001 |
Serum creatinine (mg/dl) | 2.7 ± 2.8 | 0.5 ± 0.1 | 0.8 ± 0.2 | 1.2 ± 0.3 | 2.5 ± 0.6** | 6.5 ± 2.7** | p < 0.001 |
eGFR (ml/min/1.73 m2) | 46.3 ± 37.5 | 112.8 ± 19.5 | 74.7 ± 9.4** | 46.7 ± 8.6** | 19.9 ± 3.8** | 7.9 ± 3.0** | p < 0.001 |
Urinary excreated protein (g/day) | 2.8 ± 2.1 | 2.6 ± 1.3 | 2.2 ± 1.5 | 2.8 ± 1.7 | 4.3 ± 3.8* | 2.5 ± 2.2 | p = 0.039 |
Urinary excreted albumin (g/day) | 1.9 ± 1.0 | 1.2 ± 0.9 | 1.5 ± 0.9 | 1.7 ± 1.1 | 3.1 ± 2.2* | 1.5 ± 1.1 | p = 0.017 |
Serum total protein (g/dl) | 6.1 ± 0.9 | 6.1 ± 1.2 | 6.2 ± 0.2 | 6.5 ± 0.9 | 5.5 ± 1.2 | 6.2 ± 0.7 | p = 0.023 |
Serum albumin (g/dl) | 3.1 ± 0.8 | 3.1 ± 0.9 | 2.9 ± 0.8 | 3.2 ± 0.7 | 2.6 ± 0.9 | 3.1 ± 0.7 | p = 0.101 |
Serum calcium (mg/dl) | 8.6 ± 0.9 | 8.9 ± 0.7 | 8.7 ± 0.9 | 8.9 ± 0.5 | 8.2 ± 0.9* | 8.2 ± 0.9* | p < 0.001 |
Serum phosphorus (mg/dl) | 3.9 ± 1.3 | 3.1 ± 0.7 | 3.1 ± 0.5 | 3.12 ± 0.5 | 4.1 ± 1.3 | 5.2 ± 1.4* | p < 0.001 |
Serum FGF23 (pg/ml) | 55.3 (37.1-217) | 43.8 (36.7-63.1) | 37.1 (32.0-44.0) | 47.9 (36.6-62.4) | 109.6 (36.0-176.0) | 361.8 (228.5-617.5)* | p < 0.001 |
Serum iPTH (pg/ml) | 53.0 (32.0-152.0) | 28.0 (17.5-40.0) | 33.0 (26.0-44.0) | 46.0 (35.0-56.0) | 87.0 (35.5-160.5)* | 188 (116.0-289.0)* | p < 0.001 |
Serum calcitriol (pg/ml) | 40.1 ± 26.0 | 57.1 ± 26.2 | 59.8 ± 23.9 | 52.2 ± 23.9 | 23.1 ± 9.5** | 17.6 ± 9.4** | p < 0.001 |
Prevalence of NS No.(%) | 34 (26) | 3 (17) | 5 (19) | 6 (21) | 8 (44) | 12 (31) | p = 0.225 |
Medications, n (%) | Â | Â | Â | Â | Â | Â | Â |
Anti-hypertensive agent(s) | 67 (51) | 4 (36) | 11 (41) | 5 (17) | 10 (56) | 37 (95)** | p < 0.001 |
Diuretic(s) | 35 (27) | 1 (6) | 4 (15) | 7 (24) | 5 (28) | 18 (49)** | p = 0.008 |
CaCO3 as an phosphate binder | 3 (2) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 3 (8) | p = 0.124 |
Active Vitamin D sterol (calcitriol or alfacalcidol) | 9 (7) | 0 (0) | 0 (0) | 0 (0) | 1 (6) | 8 (21)* | p = 0.002 |
Erythropoietin | 30 (23) | 0 (0) | 0 (0) | 0 (0) | 2 (11) | 28 (72)** | p < 0.001 |