Table 3 Enzymatic antioxidant activity and oxidation markers in the blood of dialysis patients before and after treatment with paricalcitol
From: Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients
n= 19 | Paricalcitol | intraCV* | interCV** | P value | ||
|---|---|---|---|---|---|---|
Baseline values | After 12 weeks | |||||
Antioxidants | ||||||
SOD, U/g Hb | 734 ± 481 | 1776 ± 574 | ↑ | 4.8 % | 3.8 % | 0.00005 |
CAT, U/g Hb | 2424 ± 832 | 3268 ± 1363 | ↑ | 2.4 % | 4.03 % | 0.0056 |
GSH, μmol/g Hb | 1.79 ± 0.76 | 2.87 ± 1.24 | ↑ | 4.4 % | 5.3 % | 0.0002 |
TRX, ng/mL | 60.2 ± 17.0 | 89.7 ± 22.1 | ↑ | 2.3 % | 3.1 % | 0.002 |
Oxidation markers | ||||||
MDA, μM | 1.14 ± 0.18 | 0.96 ± 0.14 | ↓ | 3.1 % | 2.8 % | 0.002 |
CG, nmol/mg prot | 1.78 ± 0.75 | 1.16 ± 0.45 | ↓ | 2.7 % | 3.3 % | 0.0007 |
Nitrites, μM | 7.09 ± 3.42 | 4.33 ± 3.71 | ↓ | 3.8 % | 3.4 % | 0.01 |