Figure 1

Renal structure and histopathology in UUO mice. (A) Representative T1- and T2-weighted coronal MRI images of UUO kidney at day 0, 1, 3 and 6 post obstruction. Renal pelvic space (asterisks) is progressively expanded in the obstructed kidney, and renal medulla (outlined with dotted lines), especially inner medulla and papilla, is remarkably decreased as the disease progresses. Arrows indicate urine. C, cortex; OM, outer medulla (inner stripe); IM, inner medulla; P, papilla. (B) Representative histological sections of mouse kidneys subjected to unilateral ureteral obstruction. Tubulointerstitial region increases markedly over 6 days in UUO kidneys, as indicated by destructive morphology of renal tubules (asterisks) and interstitial fibrosis (arrows). Bar=100 μm. Masson trichrome stain