SCr and renal histological injury in rats subjected to LPS at different time points. A, SCr levels are shown, with the mean values/group obtained by colorimetric assay (uM/L). There was a significant increase in SCr levels in rats at 3, 6 and 12 hours. B, Renal histology under light microscopy and TEM at 6 hours following LPS treatment (H&E, 200×; TEM, 5000×) are shown. The arrows indicate intracellular edema, inflammatory cell infiltration, microvilli in disarray, or injury to the mitochondrial outer membrane. Abbreviations: SCr = serum creatinine. **P < 0.001, relative to the control group.