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Table 1 Patient characteristic at the time of renal biopsy

From: Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis

Characteristics

 

IgAN

n = 40

IgMN

n = 37

MesPGN

without IgA/IgM n = 21

P

Age, years

 

10.2 [3.9‒15]

9.4 [3.9‒13.6]

6.2 [2.8‒13.2]

.002

Sex, male/ female

 

28/12

20/17

10/11

NS

Body weight, kg

 

33.5 [15.5‒71]

27 [14‒62.5]

20 [14‒65]

.015

Duration of disease prior to biopsy, months

 

2 [0.23‒120]

12 [0.33‒84]

6 [0.67‒48]

.012

Hematuria, n (%)

 

39 (98)

36 (97)

21 (100)

NS

Macro hematuria, n (%)

 

25 (63)

7 (19)

4 (19)

.000

Proteinuria > 4mg/m2/h, n (%)

 

27 (68)

18 (49)

11 (52)

NS

Proteinuria > 40mg/m2/h, n (%)

 

16 (40)

8 (22)

4 (19)

NS

Serum creatinine > 1.5mg/dl, n (%)

 

1 (3)

0 (0)

0 (0)

NS

Hypertensiona, n (%)

 

4 (10)

2 (5)

2 (10)

NS

Clinical features, n (%)

Isolated hematuria

13 (33)

19 (51)

10(48)

NS

 

Proteinuria with or without hematuria

18 (45)

10 (27)

6 (29)

NS

 

Nephritic syndromeb

2 (5)

1 (3)

0 (0)

NS

 

Nephrotic syndromec

6 (15)

7 (19)

5 (24)

NS

 

Acute kidney injuryd

1 (3)

0 (0)

0 (0)

NS

Histological features, n (%)

Adhesion

12 (30)

8 (22)

8 (38)

NS

Sclerosis

5 (13)

0 (0)

1 (5)

NS

Crescent

1 (3)

0 (0)

0 (0)

NS

Endocapillary hypercellularity

8 (20)

2 (5)

3 (14)

NS

Tubular atrophy

9 (23)

5 (14)

4 (19)

NS

Interstitial fibrosis

2 (5)

2 (5)

1 (5)

NS

Interstitial inflammation

6 (15)

4 (11)

2 (10)

NS

Arteriolar lesions

0 (0)

0 (0)

0 (0)

NS

Severe MC (score ≥ 2)e

20 (50)

9 (24)

5 (24)

.030

Severe GS (score ≥ 2)f

9 (23)

5 (14)

3 (14)

NS

Severe TID (score ≥ 2)g

11 (28)

5 (14)

4 (19)

NS

Severe MC + severe GS

6 (15)

2 (5)

2 (10)

NS

Severe MC + severe TID

6 (15)

2 (5)

2 (10)

NS

Severe GS + severe TID

5 (13)

3 (8)

0 (0)

NS

Severe MC + GS + TID

3 (8)

1 (3)

0 (0)

NS

Treatmen, n (%)

Prednisone

18 (45)

14 (38)

7 (33)

NS

 

Cyclophosphamide

4 (10)

3 (8)

3 (14)

NS

  1. Values are median [range]; NS, not significant; GS, Glomerulosclerosis; MC, mesangial cellularity; TID, tubule‒interstitial damage aHypertension, defined as diastolic and/or systolic pressure higher than the 95th percentile for age, sex, and height percentile. bNephritic syndrome, defined as hematuria, red blood cell casts, proteinuria, and/or renal insufficiency, and/or hypertension. cNephrotic syndrome, defined as 24‒h proteinuria > 40mg/m2/h and serum albumin level < 2.5 g/dl. dAcute kidney injury, defined as a ≥ 50% decrease in estimated creatinine clearance, based on Schwartz formula. eSevere MC (score ≥ 2), defined as > 5 mesangial cells/ mesangial area. fSevere GS (score ≥ 2), defined as ≥ 10% glomeruli showing segmental adhesions or sclerosis. gSevere TID (score ≥ 2), defined as focal or diffuse tubular and interstitial lesions
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BMC Nephrology

ISSN: 1471-2369

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