Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis

Table 5 Predictive characteristics of urinary proteins for severe renal histological lesions

	AUC	95% CI	P	Optimal cut‒off value	Sensitivity (%)	Specificity (%)
Severe mesangial cellularity
u Transferrin	0.86	0.74‒0.99	.000	45 mg/g uCr	88	74
u Albumin	0.79	0.64‒0.95	.003	372 mg/g uCr	82	74
u α₁‒microglobulin	0.78	0.62‒0.94	.005	22 mg/g uCr	82	74
u IgG	0.77	0.61‒0.92	.006	65 mg/g uCr	77	74
24‒h Proteinuria	0.78	0.63‒0.93	.004	32 mg/m²/h	77	68
Severe glomerulosclerosis
u Transferrin	0.82	0.68‒0.95	.007	136 mg/g uCr	100	74
24‒h Proteinuria	0.79	0.64‒0.93	.014	40 mg/m²/h	88	61
Severe tubule‒interstitial damage
u NAG	0.82	0.69‒0.94	.004	25 u/g uCr	75	77
u Transferrin	0.74	0.54‒0.94	.030	97 mg/g uCr	75	77

AUC, area under the receiver‒operating‒characteristic curve; CI, confidence interval.
Severe mesangial cellularity, defined as > 5 mesangial cells on per mesangial area.
Severe glomerulosclerosis, defined as ≥ 10 % glomeruli showing segmental adhesions or sclerosis.
Severe tubule‒interstitial damage, defined as focal or diffuse tubular and interstitial lesions.

ISSN: 1471-2369