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Table 3 Reclassification and adjusted hazard ratios a of all-cause and cardiovascular disease mortality by eGFR categories determined using the MDRD and the CKD-EPI study equation: NHANES III (1988–1994) - follow-up till December 31, 2006

From: Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III)

 

EGFRCKD-EPICategories

EGFR MDRD Categories

>120

90-119

60-89

30-59

<30

>120

     

Reclassified, N b (%)c

2,416 (88.3)

312 (11.7)

   

All-Cause Mortality

     

Deaths, N b

126

101

   

HR (95% CI)

REFERENCE

0.57 (0.26-1.26)

   

CVD Mortality

     

Deaths b

28

36

   

HR (95% CI)

REFERENCE

0.37 (0.15-0.94)

   

90-119

     

Reclassified, N b (%)c

1,473 (20.2)

4,969 (78.4)

162 (1.4)

  

All-Cause Mortality

     

Deaths, N b

53

604

148

  

HR (95% CI)

1.42 (0.85-2.37)

REFERENCE

1.39 (0.94-2.07)

  

CVD Mortality

     

Deaths b

13

193

72

  

HR (95% CI)

2.95 (1.03-8.42)

REFERENCE

1.79 (0.94-3.39)

  

60-89

     

Reclassified, N b (%)c

 

1,870 (42.9)

3,664 (56.6)

72 (0.5)

 

All-Cause Mortality

     

Deaths, N b

 

216

1,506

66

 

HR (95% CI)

 

1.13 (0.91-1.42)

REFERENCE

1.31 (1.01-1.69)

 

CVD Mortality

     

Deaths b

 

74

669

31

 

HR (95% CI)

 

1.02 (0.69-1.50)

REFERENCE

1.42 (1.01-1.99)

 

30-59

     

Reclassified, N b (%)c

  

120 (19.4)

883 (79.5)

12 (1.1) d

All-Cause Mortality

     

Deaths, N b

  

31

708

11

HR (95% CI)

  

0.53 (0.34-0.84)

REFERENCE

N/A

CVD Mortality

     

Deaths b

  

14

381

6

HR (95% CI)

  

0.51(0.27-0.96)

REFERENCE

N/A

  1. Abbreviations: eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; HR, Hazard Rate; CVD, cardiovascular disease; N/A, not applicable.
  2. a Adjusted for age, sex, race/ethnicity, prior CVD, systolic or diastolic blood pressure, use of antihypertensive medications, diabetes status, smoking status, body mass index, cholesterol, CRP category and albumin-to-creatinine ratio category.
  3. b Numbers represent crude (un-weighted) participant number.
  4. c Percent represents the population percent representative of the non-institutionalized US population; total may not equal 100% due to rounding.
  5. d HR not presented as there are less than 30 people in the cell.