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Table 3 Reclassification and adjusted hazard ratios a of all-cause and cardiovascular disease mortality by eGFR categories determined using the MDRD and the CKD-EPI study equation: NHANES III (1988–1994) - follow-up till December 31, 2006

From: Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III)

  EGFRCKD-EPICategories
EGFR MDRD Categories >120 90-119 60-89 30-59 <30
>120      
Reclassified, N b (%)c 2,416 (88.3) 312 (11.7)    
All-Cause Mortality      
Deaths, N b 126 101    
HR (95% CI) REFERENCE 0.57 (0.26-1.26)    
CVD Mortality      
Deaths b 28 36    
HR (95% CI) REFERENCE 0.37 (0.15-0.94)    
90-119      
Reclassified, N b (%)c 1,473 (20.2) 4,969 (78.4) 162 (1.4)   
All-Cause Mortality      
Deaths, N b 53 604 148   
HR (95% CI) 1.42 (0.85-2.37) REFERENCE 1.39 (0.94-2.07)   
CVD Mortality      
Deaths b 13 193 72   
HR (95% CI) 2.95 (1.03-8.42) REFERENCE 1.79 (0.94-3.39)   
60-89      
Reclassified, N b (%)c   1,870 (42.9) 3,664 (56.6) 72 (0.5)  
All-Cause Mortality      
Deaths, N b   216 1,506 66  
HR (95% CI)   1.13 (0.91-1.42) REFERENCE 1.31 (1.01-1.69)  
CVD Mortality      
Deaths b   74 669 31  
HR (95% CI)   1.02 (0.69-1.50) REFERENCE 1.42 (1.01-1.99)  
30-59      
Reclassified, N b (%)c    120 (19.4) 883 (79.5) 12 (1.1) d
All-Cause Mortality      
Deaths, N b    31 708 11
HR (95% CI)    0.53 (0.34-0.84) REFERENCE N/A
CVD Mortality      
Deaths b    14 381 6
HR (95% CI)    0.51(0.27-0.96) REFERENCE N/A
  1. Abbreviations: eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; HR, Hazard Rate; CVD, cardiovascular disease; N/A, not applicable.
  2. a Adjusted for age, sex, race/ethnicity, prior CVD, systolic or diastolic blood pressure, use of antihypertensive medications, diabetes status, smoking status, body mass index, cholesterol, CRP category and albumin-to-creatinine ratio category.
  3. b Numbers represent crude (un-weighted) participant number.
  4. c Percent represents the population percent representative of the non-institutionalized US population; total may not equal 100% due to rounding.
  5. d HR not presented as there are less than 30 people in the cell.