From: Total protein, albumin and low-molecular-weight protein excretion in HIV-positive patients
 |  | All patients | No cART | cART/no TFV | cART/TFV | p-value | TFV/NNRTI | TFV/PI | p-value |
---|---|---|---|---|---|---|---|---|---|
Number of patients | N (% of total) | 317 (100) | 57 (18) | 143 (45) | 117 (37) | Â | 72 (23) | 45 (14) | Â |
Age (years) | Mean (SD) (range) | 41.0 (8.9) (24.4, 64.3) | 38.0 (8.5) (21.2, 60.2) | 40.9 (8.9) (25.8, 63.3) | 42.3 (8.8) (25.7, 70.1) | 0.83 | 42.3 (9.3) (21.7, 65.8) | 42.6 (7.3) (27.5, 63.3) | 0.30 |
Male gender | N (%) | 222 (70) | 43 (75) | 89 (62) | 90 (77) | 0.02 | 54 (75) | 36 (80) | 0.53 |
Black Ethnicity | N (%) | 189 (60) | 31 (54) | 95 (66) | 63 (54) | 0.08 | 35 (49) | 28 (62) | 0.15 |
Time since HIV diagnosis (years) | Median (IQR) | 4.9 (2.1, 8.7) | 2.0 (0.5, 4.2) | 5.1 (2.2, 8.2) | 5.8 (3.1, 4.7) | 0.0001 | 5.1 (2.5, 8.2) | 7.8 (4.1, 11.4) | 0.003 |
Time since start cART (years) | Median (IQR) | 4.6 (2.6, 7.6) | 3.2 (2.6, 5.9) | 4.3 (2.6, 6.8) | 4.8 (2.6, 8.1) | 0.51 | 4.5 (2.5, 7.3) | 6.0 (3.1, 9.2) | 0.009 |
AIDS (CDC status C) | (N, %) | 77 (17) | 1 (2) | 27 (19) | 33 (28) | <0.0001 | 17 (24) | 16 (35) | 0.16 |
Nadir CD4 count (cells/mm3) | Median (IQR) | 171 (71, 262) | 290 (230, 416) | 161 (69, 250) | 146 (64, 210) | 0.0001 | 158 (82, 224) | 94 (25, 222) | 0.07 |
Current CD4 count (cells/mm3) | Median (IQR) | 389 (270, 532) | 437 (329, 560) | 363 (269, 534) | 385 (259, 517) | 0.13 | 385 (245, 512) | 376 (249, 566) | 0.62 |
Current HIV RNA (log10) | Mean (SD) | 2.4 (1.3) | 3.9 (1.1) | 2.2 (1.1) | 2.0 (1.0) | 0.0001 | 2.1 (1.1) | 2.1 (1.0) | 0.04 |
HIV RNA <50 c/mL | N (%) | 204 (65) | 4 (9) | 110 (77) | 90 (77) | <0.0001 | 60 (83) | 30 (67) | <0.0001 |
Hepatitis B surface Ag (positive) | N (%) | 15 (5) | 3 (5) | 4 (3) | 8 (7) | 0.31 | 4 (6) | 4 (9) | 0.49 |
Hepatitis C Antibody (positive) | N (%) | 20 (6) | 3 (5) | 3 (2) | 14 (12) | 0.005 | 10 (14) | 4 (9) | 0.42 |
eGFR (mL/min/1.73 m2) | Median (IQR) | 89 (78, 99) | 91 (81, 99) | 89 (80, 100) | 85 (77, 97) | 0.08 | 86 (76, 97) | 82 (76, 96) | 0.84 |
Diabetes | N (%) | 11 (4) | 0 (0) | 7 (6) | 4 (4) | 0.27 | 2 (3) | 2 (5) | 0.62 |
Hypertension | N (%) | 39 (15) | 5 (12) | 20 (16) | 14 (13) | 0.75 | 11 (17) | 3 (8) | 0.16 |
Weight (Kg) | Median (IQR) | 74.2 (66.0, 82.0) | 76.0 (68.9, 85.0) | 74.3 (65.6, 82.0) | 73.5 (66.0, 82.9) | 0.39 | 73.6 (66.4, 81.0) | 71.1 (65.6, 84.9) | 0.73 |
BMI | Median (IQR) | 24.6 (22.9, 28.1) | 25.6 (22.5, 31.4) | 25.5 (22.4, 29.6) | 23.9 (21.9, 27.1) | 0.06 | 24.1 (22.1, 26.8) | 23.5 (21.4, 27.7) | 0.73 |