Table 1 Dosing cohorts
Cohort | n | Conversion Strategy | Weekly Epoetin Alfa Dose | Peginesatide Starting Dose | Epoetin Alfa–to-Peginesatide Dose Conversion Ratio (U/kg/wk:mg/kg/mo) | 1-Week ESA-Free Interval |
|---|---|---|---|---|---|---|
A | 15 | Dose conversion ratio | NA | NA | 3030:1 | No |
B | 15 | Dose conversion ratio | NA | NA | 2439:1 | No |
C | 14 | Dose conversion ratio | NA | NA | 2000:1 | No |
D | 30 | Dose conversion ratio | NA | NA | 2000:1 | Yes |
E | 15 | Dose conversion ratio | NA | NA | 1515:1 | Yes |
F | 15 | Tiered weight-based | <100 U/kg | 0.050 mg/kg | <2000:1 | Yes |
100 to 150 U/kg | 0.075 mg/kg | 1333 to 2000:1 | ||||
> 150 to 200 U/kg | 0.100 mg/kg | 1500 to 2000:1 | ||||
>200 U/kg | 0.150 mg/kg | >1333:1 | ||||
G | 30 | Tiered weight-based | <100 U/kg | 0.050 mg/kg | <2000:1 | No |
100 to 150 U/kg | 0.075 mg/kg | 1333 to 2000:1 | ||||
>150 to 200 U/kg | 0.100 mg/kg | 1500 to 2000:1 | ||||
>200 U/kg | 0.150 mg/kg | >1333:1 | ||||
H | 30 | Tiered fixed-dose | <8000 U | 4.0 mg | <2000:1 | No |
8000 to 16000 U | 6.0 mg | 1333 to 2666:1 | ||||
>24000 U | 12.0 mg | 1333 to 2000:1 | ||||
16.0 mg | >1500:1 |