Characteristic | Cohort A n = 15 | Cohort B n = 15 | Cohort C n = 14 | Cohort D n = 30 | Cohort E n = 15 | Cohort F n = 15 | Cohort G n = 30 | Cohort H n = 30 | Total (N = 164) |
---|---|---|---|---|---|---|---|---|---|
Age, mean (SD), y | 62.8 (18.8) | 59.7 (14.2) | 55.9 (14.8) | 59.1 (14.3) | 65.7 (11.8) | 54.4 (18.3) | 57.1 (16.0) | 59.3 (13.8) | 59.1 (15.2) |
Men, no. (%) | 6 (40.0) | 9 (60.0) | 10 (71.4) | 17 (56.7) | 8 (53.3) | 10 (66.7) | 13 (43.3) | 21 (70.0) | 94 (57.3) |
Black, no. (%) | 5 (33.3) | 10 (66.7) | 7 (50.0) | 15 (50.0) | 9 (60.0) | 10 (66.7) | 18 (60.0) | 18 (60.0) | 92 (56.1) |
Hb, mean (SD), g/dL | 11.6 (0.6) | 11.6 (0.4) | 11.7 (0.6) | 11.5 (0.7) | 11.4 (0.6) | 11.5 (0.5) | 11.5 (0.6) | 11.5 (0.7) | 11.5 (0.6) |
Kt/V, mean (SD) | 1.87 (0.83) | 1.61 (0.18) | 1.52 (0.22) | 1.59 (0.27) | 1.69 (0.24) | 1.61 (0.29) | 1.79 (0.33) | 1.69 (0.24) | 1.68 (0.36) |
Ferritin, mean (SD), ng/mL | 724.1 (212.2) | 633.2 (321.2) | 635.6 (423.2) | 789.2 (510.0) | 887.7 (413.4) | 1073.9 (643.4) | 665.6 (456.6) | 564.0 (401.4) | 727.1 (458.9) |
TSAT, mean (SD),% | 36.4 (9.5) | 32.5 (4.9) | 43.1 (12.0) | 50.4 (19.4) | 52.8 (17.1) | 57.6 (16.3) | 31.6 (10.3) | 33.3 (12.0) | 41.2 (16.5) |
CHr, mean (SD), pg | 31.7 (1.9) | 32.1 (2.6) | 32.2 (2.8) | 32.4 (2.0) | 33.2 (1.7) | 32.3 (2.4) | 32.3 (1.9) | 32.7 (2.3) | 32.4 (2.2) |
Epoetin alfa dose, median | 143 | 130 | 161 | 124 | 109 | 118 | 132 | 160 | 137 |
(range) | (92–377) | (70–288) | (67–365) | (63–277) | (59–214) | (72–231) | (65–327) | (80–367) | (59–377) |
U/kg/wk | 9997 | 12444 | 12598 | 9603 | 9547 | 7600 | 7398 | 7598 | 8567 |
U/wk | (6371–33650) | (4634–21709) | (6593–36590) | (3602–24597) | (4544–30445) | (5066–10140) | (4797–10666) | (965–14820) | (965–36590) |
Primary cause of CKD, no. (%) | |||||||||
Diabetes | 6 (40.0) | 6 (40.0) | 6 (42.9) | 12 (40.0) | 6 (40.0) | 3 (20.0) | 11 (36.7) | 17 (56.7) | 67 (40.9) |
Hypertension | 4 (26.7) | 4 (26.7) | 2 (14.3) | 13 (43.3) | 6 (40.0) | 9 (60.0) | 15 (50.0) | 8 (26.7) | 61 (37.2) |
Other | 5 (33.3) | 5 (33.3) | 6 (42.9) | 5 (16.7) | 3 (20.0) | 3 (20.0) | 4 (13.3) | 5 (16.7) | 36 (22.0) |